| MP:0000438 | abnormal skull morphology | "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr
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| MP:0000439 | enlarged skull | |
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr
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| MP:0000820 | abnormal choroid plexus morphology | "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302] |
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr
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| MP:0000825 | dilated lateral ventricles | "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857] |
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr
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| MP:0000827 | dilated third ventricle | "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr
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| MP:0000829 | dilated fourth ventricle | "enlarged irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr
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| MP:0001289 | persistence of hyaloid capillary system | "failure of the degeneration of the transient vascular system of the eye during development" [J:49840] |
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Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
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| MP:0001317 | abnormal pupil morphology | "structural anomaly of the central circular aperture of the iris through which light rays enter the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Mtf1tm1Wsc/Mtf1tm1Wsc
Genetic Background: Not Specified
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| MP:0001322 | abnormal iris morphology | "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Mtf1tm1Wsc/Mtf1tm1Wsc
Genetic Background: Not Specified
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| MP:0001325 | abnormal retina morphology | "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mtf1tm1Wsc/Mtf1tm1Wsc
Genetic Background: Not Specified
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| MP:0001552 | increased circulating triglyceride level | "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416] |
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Allelic Composition: Mtf1tm1Wsc/Mtf1tm1Wsc
Genetic Background: Not Specified
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| MP:0001570 | abnormal circulating enzyme level | "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mtf1tm1Wsc/Mtf1tm1Wsc
Genetic Background: Not Specified
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| MP:0001891 | hydroencephaly | "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003] |
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr
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| MP:0001915 | intracranial hemorrhage | "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr
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| MP:0002152 | abnormal brain morphology | "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk] |
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr
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| MP:0002574 | increased vertical activity | "greater than average time spent jumping or rearing " [J:72576, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator] |
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd
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| MP:0002624 | abnormal tricuspid valve morphology | "malformation of the valve with three cusps located between the right atrium and the right ventricle of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr
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| MP:0002699 | abnormal vitreous body | "anomalies of the transparent, semigelatinous substance that fills the cavity behind the crystalline lens of the eye and in front of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
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| MP:0002792 | abnormal retinal vascularization | "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator] |
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Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms
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| MP:0003975 | increased circulating VLDL triglyceride level | "higher than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator] |
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms
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| MP:0004272 | abnormal basement membrane morphology | "anomaly in the structure, organization and/or placement of the extracellular supportive tissue adjacent to the basal surface of the epithelia, including the epithelium of muscle cells, fat cells and Schwann cells; it is comprised of type IV collagen, laminin, and sulfated proteoglycans and other components and consists of two layers, the basal lamina and the lamina reticularis" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A10.272.220] |
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Allelic Composition: Slc12a2tm2Bhk/Slc12a2tm2Bhk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * DBA/2J
Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6JOlaHsd
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| MP:0004756 | abnormal proximal convoluted tubule morphology | "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms
Allelic Composition: Col18a1tm1Pih/Col18a1tm1Pih
Genetic Background: B6JOlaHsd.Cg-Col18a1tm1Pih
Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6JOlaHsd
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| MP:0005099 | abnormal ciliary body morphology | "structural anomaly of the thickened portion of the vascular tunic, which lies between the choroid and the iris" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Mtf1tm1Wsc/Mtf1tm1Wsc
Genetic Background: Not Specified
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| MP:0005199 | abnormal iris pigment epithelium | "anomaly in the epithelial layer of the iris composed of cells containing pigment granules " [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Mtf1tm1Wsc/Mtf1tm1Wsc
Genetic Background: Not Specified
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| MP:0005319 | abnormal enzyme/ coenzyme level | "altered concentration of any of these proteins, or their cofactors, that act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Mtf1tm1Wsc/Mtf1tm1Wsc
Genetic Background: Not Specified
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| MP:0005325 | abnormal glomerulus | "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Mtf1tm1Wsc/Mtf1tm1Wsc
Genetic Background: Not Specified
Allelic Composition: Col18a1tm2Pih/Col18a1tm2Pih
Genetic Background: B6JOlaHsd.Cg-Col18a1tm2Pih
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| MP:0005541 | abnormal iris stromal pigmentation | "anomalous coloring of the framework of the iris" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms
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| MP:0005545 | abnormal lens development | "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Prndtm1Dwm/Prndtm1Dwm
Genetic Background: 129P2/OlaHsd-Prndtm1Dwm
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| MP:0005553 | increased circulating creatinine level | "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission] |
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Allelic Composition: Lamc2jeb/Lamc2jeb
Genetic Background: B6.129X1-Lamc2jeb/Dcr
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| MP:0006000 | abnormal corneal epithelium | "malformation in the one or more of the layers of epithelial cells covering the front of the cornea" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms
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| MP:0008033 | impaired lipolysis | "reduction in the rate of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms
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| MP:0008140 | podocyte foot process effacement | "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: B6.129S4-Col18a1tm1Hms
Allelic Composition: Col18a1tm2Pih/Col18a1tm2Pih
Genetic Background: B6JOlaHsd.Cg-Col18a1tm2Pih
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| MP:0011056 | abnormal brain ependyma motile cilium morphology | "any structural anomaly of the tiny, motile hair-like projections from the epithelial cells that line the ventricles in the brain, which beat in concert and to move cerebrospinal fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6JOlaHsd
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| MP:0011338 | abnormal mesangial matrix morphology | "any structural anomaly of the extracellular matrix secreted by intraglomerular mesangial cells" [MGI:csmith] |
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6JOlaHsd
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| MP:0011353 | expanded mesangial matrix | "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith] |
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6JOlaHsd
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| MP:0011380 | enlarged brain ventricle | "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb] |
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Allelic Composition: Col18a1tm1Hms/Col18a1tm1Hms
Genetic Background: involves: 129S4/SvJae * C57BL/6J * C57BL/6JOlaHsd
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| MP:0013279 | increased fasted circulating glucose level | "increase in the amount of glucose in the blood at some defined time point after eating compared to controls" [MGI:Armida_Di_Fenza] |
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Allelic Composition: Cbln3tm1.1(KOMP)Vlcg/Cbln3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cbln3tm1.1(KOMP)Vlcg/Ucd
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