ENSG00000135862


Homo sapiens

Features
Gene ID: ENSG00000135862
  
Biological name :LAMC1
  
Synonyms : LAMC1 / laminin subunit gamma 1 / P11047
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q25.3
Gene start: 183023460
Gene end: 183145592
  
Corresponding Affymetrix probe sets: 200770_s_at (Human Genome U133 Plus 2.0 Array)   200771_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000258341
Ensembl peptide - ENSP00000473583
NCBI entrez gene - 3915     See in Manteia.
OMIM - 150290
RefSeq - NM_002293
RefSeq Peptide - NP_002284
swissprot - P11047
swissprot - R4GNC7
Ensembl - ENSG00000135862
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lamc1ENSDARG00000036279Danio rerio
 LAMC1ENSGALG00000004620Gallus gallus
 Lamc1ENSMUSG00000026478Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LAMC3 / Q9Y6N6 / laminin subunit gamma 3ENSG0000005055543
LAMC2 / Q13753 / laminin subunit gamma 2ENSG0000005808532
LAMA5 / O15230 / laminin subunit alpha 5ENSG0000013070227
LAMA2 / P24043 / laminin subunit alpha 2ENSG0000019656923
LAMA3 / Q16787 / laminin subunit alpha 3ENSG0000005374723
LAMA1 / P25391 / laminin subunit alpha 1ENSG0000010168022
LAMB1 / P07942 / laminin subunit beta 1ENSG0000009113619
LAMB2 / P55268 / laminin subunit beta 2ENSG0000017203719
LAMB4 / A4D0S4 / laminin subunit beta 4ENSG0000009112818
LAMB3 / Q13751 / laminin subunit beta 3ENSG0000019687814
LAMA4 / Q16363 / laminin subunit alpha 4ENSG0000011276910
NTN4 / Q9HB63 / netrin 4ENSG0000007452710


Protein motifs (from Interpro)
Interpro ID Name
 IPR000034  Laminin IV
 IPR000742  EGF-like domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0007492 endoderm development TAS
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0022617 extracellular matrix disassembly IMP
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0031581 hemidesmosome assembly IMP
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IDA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0050679 positive regulation of epithelial cell proliferation TAS
 biological_processGO:0065003 protein-containing complex assembly IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane TAS
 cellular_componentGO:0005606 laminin-1 complex IEA
 cellular_componentGO:0005615 extracellular space NAS
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0043259 laminin-10 complex TAS
 cellular_componentGO:0043260 laminin-11 complex TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005201 extracellular matrix structural constituent IMP


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Laminin interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
L1CAM interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
MET activates PTK2 signaling
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000005884 ITGA3 / P26006 / integrin subunit alpha 3  / reaction / complex
 ENSG00000132470 ITGB4 / P16144 / integrin subunit beta 4  / reaction / complex
 ENSG00000091409 ITGA6 / P23229 / integrin subunit alpha 6  / reaction / complex
 ENSG00000198910 L1CAM / P32004 / L1 cell adhesion molecule  / complex / reaction
 ENSG00000053747 LAMA3 / Q16787 / laminin subunit alpha 3  / complex
 ENSG00000196569 LAMA2 / P24043 / laminin subunit alpha 2  / complex
 ENSG00000172037 LAMB2 / P55268 / laminin subunit beta 2  / complex
 ENSG00000173402 DAG1 / Q14118 / dystroglycan 1  / complex / reaction
 ENSG00000112769 LAMA4 / Q16363 / laminin subunit alpha 4  / complex
 ENSG00000091136 LAMB1 / P07942 / laminin subunit beta 1  / complex
 ENSG00000101680 LAMA1 / P25391 / laminin subunit alpha 1  / complex
 ENSG00000130702 LAMA5 / O15230 / laminin subunit alpha 5  / complex
 ENSG00000198947 DMD / P11532 / dystrophin  / complex / reaction
 ENSG00000157227 MMP14 / P50281 / matrix metallopeptidase 14  / reaction
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / reaction / complex
 ENSG00000182871 P39060 / COL18A1 / collagen type XVIII alpha 1 chain  / complex / reaction
 ENSG00000187045 Q8IU80 / TMPRSS6 / transmembrane serine protease 6  / reaction






 

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