ENSG00000130702


Homo sapiens

Features
Gene ID: ENSG00000130702
  
Biological name :LAMA5
  
Synonyms : LAMA5 / laminin subunit alpha 5 / O15230
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q13.33
Gene start: 62307955
Gene end: 62367312
  
Corresponding Affymetrix probe sets: 210150_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000481814
Ensembl peptide - ENSP00000252999
Ensembl peptide - ENSP00000420069
NCBI entrez gene - 3911     See in Manteia.
OMIM - 601033
RefSeq - XM_011528819
RefSeq - NM_005560
RefSeq - XM_006723796
RefSeq - XM_006723798
RefSeq - XM_011528818
RefSeq Peptide - NP_005551
swissprot - H7C5J6
swissprot - A0A087WYH7
swissprot - O15230
Ensembl - ENSG00000130702
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lama5ENSDARG00000058543Danio rerio
 ENSGALG00000005321Gallus gallus
 Lama5ENSMUSG00000015647Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LAMA3 / Q16787 / laminin subunit alpha 3ENSG0000005374739
LAMA2 / P24043 / laminin subunit alpha 2ENSG0000019656924
LAMA1 / P25391 / laminin subunit alpha 1ENSG0000010168022
LAMC3 / Q9Y6N6 / laminin subunit gamma 3ENSG0000005055513
LAMA4 / Q16363 / laminin subunit alpha 4ENSG0000011276913
LAMB2 / P55268 / laminin subunit beta 2ENSG0000017203713
LAMB4 / A4D0S4 / laminin subunit beta 4ENSG0000009112812
LAMC1 / P11047 / laminin subunit gamma 1ENSG0000013586212
LAMB1 / P07942 / laminin subunit beta 1ENSG0000009113612
LAMC2 / Q13753 / laminin subunit gamma 2ENSG000000580858
LAMB3 / Q13751 / laminin subunit beta 3ENSG000001968787
NTN4 / Q9HB63 / netrin 4ENSG000000745275


Protein motifs (from Interpro)
Interpro ID Name
 IPR000034  Laminin IV
 IPR000742  EGF-like domain
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR001791  Laminin G domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily
 IPR009254  Laminin alpha, domain I
 IPR010307  Laminin domain II
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis NAS
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001738 morphogenesis of a polarized epithelium IEA
 biological_processGO:0001755 neural crest cell migration IEA
 biological_processGO:0001942 hair follicle development IEA
 biological_processGO:0007010 cytoskeleton organization NAS
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007229 integrin-mediated signaling pathway IMP
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0008037 cell recognition NAS
 biological_processGO:0008283 cell proliferation NAS
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0016331 morphogenesis of embryonic epithelium IEA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030154 cell differentiation NAS
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0030198 extracellular matrix organization TAS
 biological_processGO:0030324 lung development IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0034446 substrate adhesion-dependent cell spreading IDA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IEA
 biological_processGO:0045446 endothelial cell differentiation NAS
 biological_processGO:0045995 regulation of embryonic development IEA
 biological_processGO:0048041 focal adhesion assembly NAS
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0060271 cilium assembly IEA
 biological_processGO:0060445 branching involved in salivary gland morphogenesis IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005605 basal lamina IEA
 cellular_componentGO:0005610 laminin-5 complex IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005634 nucleus HDA
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0043083 synaptic cleft IEA
 cellular_componentGO:0043259 laminin-10 complex TAS
 cellular_componentGO:0043260 laminin-11 complex TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Degradation of the extracellular matrix
Laminin interactions
Non-integrin membrane-ECM interactions
ECM proteoglycans
Interleukin-4 and Interleukin-13 signaling
MET activates PTK2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000005884 ITGA3 / P26006 / integrin subunit alpha 3  / reaction / complex
 ENSG00000132470 ITGB4 / P16144 / integrin subunit beta 4  / complex / reaction
 ENSG00000091136 LAMB1 / P07942 / laminin subunit beta 1  / complex
 ENSG00000058085 LAMC2 / Q13753 / laminin subunit gamma 2  / complex
 ENSG00000130702 LAMA5 / O15230 / laminin subunit alpha 5  / complex
 ENSG00000091409 ITGA6 / P23229 / integrin subunit alpha 6  / reaction / complex
 ENSG00000135862 LAMC1 / P11047 / laminin subunit gamma 1  / complex
 ENSG00000157227 MMP14 / P50281 / matrix metallopeptidase 14  / reaction
 ENSG00000172037 LAMB2 / P55268 / laminin subunit beta 2  / complex
 ENSG00000150093 ITGB1 / P05556 / integrin subunit beta 1  / complex / reaction
 ENSG00000187045 Q8IU80 / TMPRSS6 / transmembrane serine protease 6  / reaction






 

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