ENSG00000074527


Homo sapiens

Features
Gene ID: ENSG00000074527
  
Biological name :NTN4
  
Synonyms : netrin 4 / NTN4 / Q9HB63
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q22
Gene start: 95657807
Gene end: 95791152
  
Corresponding Affymetrix probe sets: 223315_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000447292
Ensembl peptide - ENSP00000447594
Ensembl peptide - ENSP00000339436
Ensembl peptide - ENSP00000340998
Ensembl peptide - ENSP00000444432
NCBI entrez gene - 59277     See in Manteia.
OMIM - 610401
RefSeq - NM_021229
RefSeq Peptide - NP_067052
swissprot - F8W0I7
swissprot - Q9HB63
Ensembl - ENSG00000074527
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ntn4ENSDARG00000102066Danio rerio
 NTN4ENSGALG00000011406Gallus gallus
 Ntn4ENSMUSG00000020019Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
LAMB1 / P07942 / laminin subunit beta 1ENSG0000009113637
LAMB4 / A4D0S4 / laminin subunit beta 4ENSG0000009112836
LAMB2 / P55268 / laminin subunit beta 2ENSG0000017203736
LAMB3 / Q13751 / laminin subunit beta 3ENSG0000019687831
LAMA5 / O15230 / laminin subunit alpha 5ENSG0000013070227
LAMA3 / Q16787 / laminin subunit alpha 3ENSG0000005374726
LAMC1 / P11047 / laminin subunit gamma 1ENSG0000013586225
LAMA2 / P24043 / laminin subunit alpha 2ENSG0000019656924
LAMC3 / Q9Y6N6 / laminin subunit gamma 3ENSG0000005055524
LAMA1 / P25391 / laminin subunit alpha 1ENSG0000010168022
LAMC2 / Q13753 / laminin subunit gamma 2ENSG0000005808511
LAMA4 / Q16363 / laminin subunit alpha 4ENSG000001127699


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR018933  Netrin module, non-TIMP type
 IPR035811  Netrin-4, NTR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007411 axon guidance TAS
 biological_processGO:0016322 neuron remodeling IEA
 biological_processGO:0060668 regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043237 laminin-1 binding IEA


Pathways (from Reactome)
Pathway description
Non-integrin membrane-ECM interactions
Netrin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000187323 DCC / P43146 / DCC netrin 1 receptor  / reaction / complex
 ENSG00000113763 UNC5A / Q6ZN44 / unc-5 netrin receptor A  / reaction / complex






 

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