ENSMUSG00000020019


Mus musculus

Features
Gene ID: ENSMUSG00000020019
  
Biological name :Ntn4
  
Synonyms : Netrin-4 / Ntn4 / Q9JI33
  
Possible biological names infered from orthology : Q9HB63
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C2
Gene start: 93640681
Gene end: 93747207
  
Corresponding Affymetrix probe sets: 10365817 (MoGene1.0st)   1439794_at (Mouse Genome 430 2.0 Array)   1450512_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000123306
Ensembl peptide - ENSMUSP00000020204
NCBI entrez gene - 57764     See in Manteia.
MGI - MGI:1888978
RefSeq - NM_021320
RefSeq Peptide - NP_067295
swissprot - D3Z053
swissprot - Q9JI33
Ensembl - ENSMUSG00000020019
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ntn4ENSDARG00000102066Danio rerio
 NTN4ENSGALG00000011406Gallus gallus
 NTN4ENSG00000074527Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lamb2 / Q61292 / Laminin subunit beta-2 / P55268*ENSMUSG0000005291137
Lamb1 / P02469 / Laminin subunit beta-1 / P07942*ENSMUSG0000000290036
Lamb3 / Q61087 / Laminin subunit beta-3 / Q13751*ENSMUSG0000002663932
Lama5 / Q61001 / Laminin subunit alpha-5 / O15230*ENSMUSG0000001564728
Lamc1 / laminin subunit gamma 1 / P11047*ENSMUSG0000002647825
Lama3 / Q61789 / Mus musculus laminin, alpha 3 (Lama3), transcript variant 2, mRNA. / Q16787* / laminin subunit alpha 3*ENSMUSG0000002442125
Lama2 / Q60675 / Laminin subunit alpha-2 / P24043*ENSMUSG0000001989924
Lama1 / laminin subunit alpha 1 / P25391*ENSMUSG0000003279623
Lamc3 / Q9R0B6 / Laminin subunit gamma-3 / Q9Y6N6*ENSMUSG0000002684023
Lamc2 / laminin subunit gamma 2 / Q13753*ENSMUSG0000002647911
Lama4 / P97927 / Laminin subunit alpha-4 / Q16363*ENSMUSG000000198468


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR018933  Netrin module, non-TIMP type
 IPR035811  Netrin-4, NTR domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016322 neuron remodeling IDA
 biological_processGO:0060668 regulation of branching involved in salivary gland morphogenesis by extracellular matrix-epithelial cell signaling IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005604 basement membrane ISS
 cellular_componentGO:0005886 plasma membrane TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043237 laminin-1 binding IDA


Pathways (from Reactome)
Pathway description
Netrin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: involves: C57BL/10ScSn * CB17

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Nr6a1tm1b(EUCOMM)Wtsi/Nr6a1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Nr6a1tm1b(EUCOMM)Wtsi/Bay

 MP:0002792 abnormal retinal vascularization "malformation or disorganization of the blood vessels supplying the retina" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: involves: C57BL/10ScSn * CB17

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: involves: C57BL/10ScSn * CB17

 MP:0008056 abnormal retinal ganglion cell morphology "any structural anomaly of ganglion neurons located in the innermost nuclear layer of the retina of that receive visual information from photoreceptors via various intermediate cells such as bipolar cells, amacrine cells, and horizontal cells; axons from these cells form the optic nerve and connect mainly to the lateral geniculate nucleus (LGN) and to the suprachiasmatic nucleus in the brain" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: involves: C57BL/10ScSn * CB17

 MP:0009450 abnormal axon fasiculation "anomaly in the process by which axons form into bundles" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Dmdmdx/Dmdmdx
Genetic Background: involves: C57BL/10ScSn * CB17

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025876 Unc5a / Q8K1S4 / unc-5 netrin receptor A / Q6ZN44*  / complex / reaction
 ENSMUSG00000060534 Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*  / reaction / complex






 

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