ENSMUSG00000025876


Mus musculus

Features
Gene ID: ENSMUSG00000025876
  
Biological name :Unc5a
  
Synonyms : Q8K1S4 / Unc5a / unc-5 netrin receptor A
  
Possible biological names infered from orthology : Q6ZN44
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: B1
Gene start: 54949411
Gene end: 55006018
  
Corresponding Affymetrix probe sets: 10405355 (MoGene1.0st)   1434095_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026994
Ensembl peptide - ENSMUSP00000105621
Ensembl peptide - ENSMUSP00000115531
Ensembl peptide - ENSMUSP00000116585
NCBI entrez gene - 107448     See in Manteia.
MGI - MGI:894682
RefSeq - XM_006517037
RefSeq - XM_006517038
RefSeq - NM_001311128
RefSeq - NM_153131
RefSeq Peptide - NP_001298057
RefSeq Peptide - NP_694771
swissprot - Q8K1S4
swissprot - F7CVI0
swissprot - F6TGW0
Ensembl - ENSMUSG00000025876
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 unc5aENSDARG00000099034Danio rerio
 UNC5AENSGALG00000018998Gallus gallus
 UNC5AENSG00000113763Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Unc5c / O08747 / unc-5 netrin receptor C / O95185*ENSMUSG0000005992155
Unc5b / Q8K1S3 / unc-5 netrin receptor B / Q8IZJ1*ENSMUSG0000002009954
Unc5d / Q8K1S2 / unc-5 netrin receptor D / Q6UXZ4*ENSMUSG0000006362646
Unc5cl / unc-5 family C-terminal like / Q8IV45*ENSMUSG0000004359213


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR000906  ZU5 domain
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR011029  Death-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR033772  UPA domain
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0031175 neuron projection development ISS
 biological_processGO:0033564 anterior/posterior axon guidance IMP
 biological_processGO:0038007 netrin-activated signaling pathway IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane ISS
 cellular_componentGO:0032589 neuron projection membrane ISS
 cellular_componentGO:0032809 neuronal cell body membrane ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005042 netrin receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Netrin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP)Luo/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003204 decreased neuron apoptosis "decrease in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP)Luo/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005192 increased motor neuron number "greater than the normal number of cells that innervate an effector (muscle or glandular) tissue" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP)Luo/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020019 Ntn4 / Q9JI33 / Netrin-4 / Q9HB63*  / complex / reaction
 ENSMUSG00000025151 Maged1 / Q9QYH6 / Melanoma-associated antigen D1 / Q9Y5V3* / MAGE family member D1*  / reaction / complex
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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