ENSMUSG00000020099


Mus musculus

Features
Gene ID: ENSMUSG00000020099
  
Biological name :Unc5b
  
Synonyms : Q8K1S3 / Unc5b / unc-5 netrin receptor B
  
Possible biological names infered from orthology : Q8IZJ1
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B4
Gene start: 60762593
Gene end: 60831581
  
Corresponding Affymetrix probe sets: 10369388 (MoGene1.0st)   1435110_at (Mouse Genome 430 2.0 Array)   1453269_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077080
Ensembl peptide - ENSMUSP00000151251
NCBI entrez gene - 107449     See in Manteia.
MGI - MGI:894703
RefSeq - XM_006513028
RefSeq - NM_029770
RefSeq Peptide - NP_084046
RefSeq Peptide - NP_001346202
swissprot - Q8K1S3
Ensembl - ENSMUSG00000020099
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 unc5bENSDARG00000033327Danio rerio
 UNC5BENSGALG00000004569Gallus gallus
 UNC5BENSG00000107731Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Unc5c / O08747 / unc-5 netrin receptor C / O95185*ENSMUSG0000005992163
Unc5d / Q8K1S2 / unc-5 netrin receptor D / Q6UXZ4*ENSMUSG0000006362651
Unc5a / Q8K1S4 / unc-5 netrin receptor A / Q6ZN44*ENSMUSG0000002587651
Unc5cl / unc-5 family C-terminal like / Q8IV45*ENSMUSG0000004359214


Protein motifs (from Interpro)
Interpro ID Name
 IPR000488  Death domain
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR000906  ZU5 domain
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR011029  Death-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR033772  UPA domain
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007411 axon guidance ISO
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling ISO
 biological_processGO:0033564 anterior/posterior axon guidance IMP
 biological_processGO:0038007 netrin-activated signaling pathway IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISO
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand ISO
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0005042 netrin receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
Show

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Unc5btm1Matl/Unc5btm1Matl
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Unc5btm1Matl/Unc5btm1Matl
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0003658 abnormal capillaries "malformation in the minute blood vessels that connect arterioles and venules" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96775]
Show

Allelic Composition: Unc5btm1Matl/Unc5btm1Matl
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

Allelic Composition: Unc5btm1Matl/Unc5btm1Matl
Genetic Background: involves: 129P2/OlaHsd * CD-1

 MP:0020327 abnormal capillary branching pattern "any changes in the placement, morphology or number of divisions of the capillaries" [ORCID: orcid.org/0000-0003-4606-0597, PMID:14713950]
Show

Allelic Composition: Unc5btm1Matl/Unc5btm1Matl
Genetic Background: involves: 129P2/OlaHsd * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021559 Dapk1 / Q80YE7 / Death-associated protein kinase 1 / P53355*  / reaction / complex






 

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