Manteia - Molecule gene

ENSMUSG00000060534

Mus musculus

Features

Gene ID:	ENSMUSG00000060534

Biological name :	Dcc

Synonyms :	Dcc / Netrin receptor DCC / P70211

Possible biological names infered from orthology :	DCC netrin 1 receptor / P43146

Species:	Mus musculus

Chr. number:	18
Strand:	-1
Band:	E2
Gene start:	71258738
Gene end:	72351069

Corresponding Affymetrix probe sets:	10459671 (MoGene1.0st) 1422162_at (Mouse Genome 430 2.0 Array) 1440487_at (Mouse Genome 430 2.0 Array) 1441572_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000073094 Ensembl peptide - ENSMUSP00000110593 NCBI entrez gene - 13176 See in Manteia. MGI - MGI:94869 RefSeq - XM_006525588 RefSeq - NM_007831 RefSeq Peptide - NP_031857 swissprot - P70211 Ensembl - ENSMUSG00000060534

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
CABZ01088906.1	ENSDARG00000104282	Danio rerio
DCC	ENSG00000187323	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Neo1 / neogenin / Q92859* / neogenin 1*	ENSMUSG00000032340	51
Sdk2 / Q6V4S5 / Protein sidekick-2 / Q58EX2* / sidekick cell adhesion molecule 2*	ENSMUSG00000041592	24
Sdk1 / Q3UH53 / Protein sidekick-1 / Q7Z5N4* / sidekick cell adhesion molecule 1*	ENSMUSG00000039683	24
Dscam / Q9ERC8 / Down syndrome cell adhesion molecule homolog / O60469* / DS cell adhesion molecule*	ENSMUSG00000050272	22
Dscaml1 / DS cell adhesion molecule like 1 / Q8TD84*	ENSMUSG00000032087	21
Igdcc4 / Q9EQS9 / Immunoglobulin superfamily DCC subclass member 4 / Q8TDY8*	ENSMUSG00000032816	21
Prtg / Q2EY15 / Protogenin / Q2VWP7*	ENSMUSG00000036030	21
Igdcc3 / Q8BQC3 / Immunoglobulin superfamily DCC subclass member 3 / Q8IVU1*	ENSMUSG00000032394	14

Protein motifs (from Interpro)

Interpro ID	Name
IPR003598	Immunoglobulin subtype 2
IPR003599	Immunoglobulin subtype
IPR003961	Fibronectin type III
IPR007110	Immunoglobulin-like domain
IPR010560	Neogenin, C-terminal
IPR013098	Immunoglobulin I-set
IPR013783	Immunoglobulin-like fold
IPR021157	Cytochrome c1, transmembrane anchor, C-terminal
IPR033012	Netrin receptor DCC
IPR036116	Fibronectin type III superfamily
IPR036179	Immunoglobulin-like domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001764	neuron migration	IMP
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0007399	nervous system development	IEA
biological_process	GO:0007411	axon guidance	IEA
biological_process	GO:0021965	spinal cord ventral commissure morphogenesis	IMP
biological_process	GO:0033563	dorsal/ventral axon guidance	IMP
biological_process	GO:0033564	anterior/posterior axon guidance	IMP
biological_process	GO:0038007	netrin-activated signaling pathway	IEA
biological_process	GO:1901214	regulation of neuron death	ISO
cellular_component	GO:0005886	plasma membrane	TAS
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
cellular_component	GO:0030424	axon	IDA
molecular_function	GO:0005042	netrin receptor activity	IEA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

Netrin-1 signaling

DCC mediated attractive signaling

via Dependence Receptors in the absence of ligand

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0000218	increased WBC count	"greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0000321	increased bone marrow cell number	"increased number of cells that make up the core cavitites of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0000322	increased granulocyte number	"greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0000689	abnormal spleen morphology	"atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0001272	increased metastatic potential		Show Allelic Composition: Dcc^tm1Nki/Dcc^tm1Nki,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/? Genetic Background: involves: 129P2/OlaHsd * FVB/N Allelic Composition: Apc^tm1Rak/Apc⁺,Dcc^tm1.1Mehl/Dcc^tm1.1Mehl Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0001330	abnormal optic nerve morphology	"malformation, misprojection or atrophy in the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Apc^Min/Apc⁺,Dcc^tm1Wbg/Dcc⁺ Genetic Background: involves: C57BL/6J
MP:0001332	abnormal optic nerve innervation	"misprojection or aberrant target finding of the second cranial nerve which is responsible for conveying visual information from the retina to the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Apc^Min/Apc⁺,Dcc^tm1Wbg/Dcc⁺ Genetic Background: involves: C57BL/6J
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Vegfa^tm2.1Nagy/Vegfa^tm2.1Nagy Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Dcc^kanga/Dcc^tm1Wbg Genetic Background: involves: 129X1/SvJ * AKR * C3H
MP:0001406	abnormal gait	"unusual or distinctive way of walking" [J:65038]	Show Allelic Composition: Vegfa^tm2.1Nagy/Vegfa^tm2.1Nagy Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0001436	abnormal suckling behavior	"reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]	Show Allelic Composition: Vegfa^tm2.1Nagy/Vegfa^tm2.1Nagy Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0001883	mammary adenocarcinoma	"higher than normal incidence of malignant tumors of the mammary gland" [J:62919]	Show Allelic Composition: Dcc^tm1.1Nki/Dcc^tm1.1Nki Genetic Background: involves: 129P2/OlaHsd
MP:0001954	respiratory distress	"physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]	Show Allelic Composition: Vegfa^tm2.1Nagy/Vegfa^tm2.1Nagy Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0002020	increased tumor incidence	"greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]	Show Allelic Composition: Dcc^tm1Nki/Dcc^tm1Nki,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/? Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0002123	abnormal hematopoiesis	"abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj,Mir34a^tm1.1Lhe/Mir34a^tm1.1Lhe Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J
MP:0002196	acallosal	"absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Vegfa^tm2.1Nagy/Vegfa^tm2.1Nagy Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Dcc^kanga/Dcc^kanga Genetic Background: involves: AKR * C3H Allelic Composition: Dcc^kanga/Dcc^tm1Wbg Genetic Background: involves: 129X1/SvJ * AKR * C3H Allelic Composition: Dcc^tm1.1Nki/Dcc^tm1.1Nki Genetic Background: involves: 129P2/OlaHsd
MP:0002404	intestinal adenoma	"benign tumors of the small and large intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Apc^Min/Apc⁺,Dcc^tm1Wbg/Dcc⁺ Genetic Background: involves: C57BL/6J Allelic Composition: Dcc^tm1.1Mehl/Dcc^tm1.1Mehl Genetic Background: Not Specified
MP:0002417	abnormal megakaryocyte morphology/development	"anomalous structure or formation of the very large cells found in the bone marrow that release platelets" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0002872	polycythemia	"an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0002878	abnormal corticospinal tract	"anomaly in the structure or function of the fibers that arise from the cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Dcc^kanga/Dcc^kanga Genetic Background: involves: AKR * C3H Allelic Composition: Dcc^kanga/Dcc^tm1Wbg Genetic Background: involves: 129X1/SvJ * AKR * C3H
MP:0002957	intestinal adenocarcinoma	"malignant neoplasm of epithelial cells in the intestine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Dcc^tm1.1Mehl/Dcc^tm1.1Mehl Genetic Background: Not Specified Allelic Composition: Apc^tm1Rak/Apc⁺,Dcc^tm1.1Mehl/Dcc^tm1.1Mehl Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002961	abnormal axon guidance	"defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]	Show Allelic Composition: Vegfa^tm2.1Nagy/Vegfa^tm2.1Nagy Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Dcc^kanga/Dcc^kanga Genetic Background: involves: AKR * C3H Allelic Composition: Dcc^tm1Wbg/Dcc⁺,Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL/J Allelic Composition: Dcc^tm1Wbg/Dcc⁺,Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c⁺ Genetic Background: involves: 129X1/SvJ * C57BL/6J * SJL/J Allelic Composition: Dcc^kanga/Dcc^tm1Wbg Genetic Background: involves: 129X1/SvJ * AKR * C3H
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0005012	decreased eosinophil count	"fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Cecr2^{tm2b(EUCOMM)Hmgu}/Cecr2⁺ Genetic Background: C57BL/6N-Cecr2^{tm2b(EUCOMM)Hmgu}/Tcp
MP:0005065	abnormal neutrophil morphology	"structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0005103	abnormal retinal pigmentation	"anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Apc^Min/Apc⁺,Dcc^tm1Wbg/Dcc⁺ Genetic Background: involves: C57BL/6J
MP:0005505	increased platelet count	"greater than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0006043	decreased apoptosis	"less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Dcc^tm1Nki/Dcc^tm1Nki,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/? Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0008223	absent hippocampal commissure	"absence of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Vegfa^tm2.1Nagy/Vegfa^tm2.1Nagy Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Dcc^kanga/Dcc^kanga Genetic Background: involves: AKR * C3H Allelic Composition: Dcc^kanga/Dcc^tm1Wbg Genetic Background: involves: 129X1/SvJ * AKR * C3H
MP:0008254	increased megakaryocyte cell number	"greater number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0008476	increased spleen red pulp amount	"increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0008479	decreased spleen white pulp amount	"reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0008884	abnormal enterocyte apoptosis	"change in the timing or the number of enterocytes undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dcc^tm1.1Mehl/Dcc^tm1.1Mehl Genetic Background: Not Specified
MP:0008973	decreased erythroid progenitor cell number	"reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0009677	abnormal spinal cord dorsal column morphology	"any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN-10:0940780577 "Goldberg, S, Clinical Neuroanatomy Made Ridiculously Simple, 3rd edition"]	Show Allelic Composition: Vegfa^tm2.1Nagy/Vegfa^tm2.1Nagy Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1
MP:0009681	abnormal pyramidal decussation morphology	"any structural anomaly of the bundles of pyramidal fibers that intercross obliquely over the midline at the lower border region of the medulla oblongata" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Dcc^kanga/Dcc^kanga Genetic Background: involves: AKR * C3H Allelic Composition: Dcc^kanga/Dcc^tm1Wbg Genetic Background: involves: 129X1/SvJ * AKR * C3H
MP:0010273	increased classified tumor incidence	"greater than the expected number of tumors with a specific classification type in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dcc^tm1Nki/Dcc^tm1Nki,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/? Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0010279	increased gastrointestinal tumor incidence	"greater than the expected number of tumors originating in the gastrointestinal system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Apc^tm1Rak/Apc⁺,Dcc^tm1.1Mehl/Dcc^tm1.1Mehl Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0010307	abnormal tumor latency	"anomaly in the expected time of onset of tumor occurrence" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Dcc^tm1Nki/Dcc^tm1Nki,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/? Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0010367	increased spindle cell carcinoma incidence	"greater than the expected number of a highly malignant variant of squamous cell carcinoma, occurring in a specific population in a given time period; spindle cell carcinoma shows biphasic proliferation of conventional SCC component and malignant spindle shape cells with sarcomatous appearance" [PMID:19040765]	Show Allelic Composition: Dcc^tm1Nki/Dcc^tm1Nki,Trp53^tm1Brn/Trp53^tm1Brn,Tg(KRT14-cre)8Brn/? Genetic Background: involves: 129P2/OlaHsd * FVB/N
MP:0010373	myeloid hyperplasia	"greater than normal number of nucleated cells of the myeloid lineage (a monocyte, granulocyte, or mast cell), found in blood or other tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0011087	complete neonatal lethality	"death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]	Show Allelic Composition: Vegfa^tm2.1Nagy/Vegfa^tm2.1Nagy Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Dcc^tm1.1Nki/Dcc^tm1.1Nki Genetic Background: involves: 129P2/OlaHsd
MP:0011100	complete preweaning lethality	"death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]	Show Allelic Composition: Cecr2^{tm2b(EUCOMM)Hmgu}/Cecr2⁺ Genetic Background: C57BL/6N-Cecr2^{tm2b(EUCOMM)Hmgu}/Tcp
MP:0011178	increased erythroblast number	"greater number of the nucleated precursor of erythrocytes" [MGI:csmith]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0011723	ectopic neuron	"appearance of a neuron or group of neurons in a region where it is not normally found" [MGI:csmith]	Show Allelic Composition: Unc5c^{rcmTg(Ucp)1.23Kz}/Unc5c^{rcmTg(Ucp)1.23Kz} Genetic Background: B6.Cg-Unc5c^{rcmTg(Ucp)1.23Kz}
MP:0013294	prenatal lethality prior to heart atrial septation	"death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]	Show Allelic Composition: Cecr2^{tm2b(EUCOMM)Hmgu}/Cecr2⁺ Genetic Background: C57BL/6N-Cecr2^{tm2b(EUCOMM)Hmgu}/Tcp
MP:0013502	decreased fibroblast apoptosis	"reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]	Show Allelic Composition: Dcc^tm1.1Mehl/Dcc^tm1.1Mehl Genetic Background: Not Specified
MP:0020399	enhanced megakaryocyte emperipolesis	"an increase in the process by which a a megakaryocyte is penetrated by another living cell" [PMID:25654060, PMID:26950939]	Show Allelic Composition: Npr2^pwe/Npr2^pwe Genetic Background: involves: C3H/HeJ * C57BL/6 * NAW/WI
MP:0020560	abnormal pontine nuclei morphology	"any structural anomaly of nuclei in the basal pons, intermingled among the descending axons from the cortex, that receive neocortcial input and give rise to many axons that cross the midline to enter the contralateral cerebellum" [UBERON:0002151]	Show Allelic Composition: Vegfa^tm2.1Nagy/Vegfa^tm2.1Nagy Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1 Allelic Composition: Dcc^kanga/Dcc^kanga Genetic Background: involves: AKR * C3H

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000020900	Myh10 / Q61879 / Myosin-10 / P35580* / myosin heavy chain 10*	/ reaction / complex
ENSMUSG00000040760	Appl1 / Q8K3H0 / DCC-interacting protein 13-alpha / Q9UKG1* / adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1*	/ reaction / complex
ENSMUSG00000027646	Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*	/ reaction / complex
ENSMUSG00000040749	Siah1b / siah E3 ubiquitin protein ligase 1B / SIAH1* / Q8IUQ4* / siah E3 ubiquitin protein ligase 1*	/ complex / reaction
ENSMUSG00000036432	Siah2 / Q06986 / siah E3 ubiquitin protein ligase 2 / O43255*	/ complex / reaction
ENSMUSG00000036840	Siah1a / P61092 / E3 ubiquitin-protein ligase SIAH1A / SIAH1* / Q8IUQ4* / siah E3 ubiquitin protein ligase 1*	/ complex / reaction
ENSMUSG00000052397	Ezr / Ezrin / P26040 / P15311*	/ complex / reaction
ENSMUSG00000022263	Trio / Q0KL02 / Triple functional domain protein / O75962* / trio Rho guanine nucleotide exchange factor*	/ reaction / complex
ENSMUSG00000001847	Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*	/ complex / reaction
ENSMUSG00000058325	Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*	/ complex / reaction
ENSMUSG00000020019	Ntn4 / Q9JI33 / Netrin-4 / Q9HB63*	/ complex / reaction
ENSMUSG00000059921	Unc5c / O08747 / unc-5 netrin receptor C / O95185*	/ complex
ENSMUSG00000050272	Dscam / Q9ERC8 / Down syndrome cell adhesion molecule homolog / O60469* / DS cell adhesion molecule*	/ complex / reaction
ENSMUSG00000032128	Robo3 / roundabout guidance receptor 3 / Q96MS0*	/ reaction / complex
ENSMUSG00000043733	P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*	/ complex / reaction
ENSMUSG00000022607	Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*	/ complex / reaction
ENSMUSG00000020902	Ntn1 / O09118 / Netrin-1 / O95631*	/ reaction / complex
ENSMUSG00000060534	Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*	/ reaction / complex
ENSMUSG00000029684	Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*	/ reaction / complex
ENSMUSG00000028914	Casp9 / Q8C3Q9 / Mus musculus caspase 9 (Casp9), transcript variant 3, mRNA. / P55211* / caspase 9*	/ reaction / complex
ENSMUSG00000019843	Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*	/ reaction / complex
ENSMUSG00000031628	Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*	/ reaction
ENSMUSG00000017781	P53810 / Pitpna / phosphatidylinositol transfer protein, alpha / Q00169*	/ complex / reaction
ENSMUSG00000032475	Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*	/ complex / reaction

1 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr