ENSMUSG00000020902


Mus musculus

Features
Gene ID: ENSMUSG00000020902
  
Biological name :Ntn1
  
Synonyms : Netrin-1 / Ntn1 / O09118
  
Possible biological names infered from orthology : O95631
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 68209364
Gene end: 68400823
  
Corresponding Affymetrix probe sets: 10387170 (MoGene1.0st)   1422987_at (Mouse Genome 430 2.0 Array)   1454974_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000104314
Ensembl peptide - ENSMUSP00000121193
Ensembl peptide - ENSMUSP00000021284
NCBI entrez gene - 18208     See in Manteia.
MGI - MGI:105088
RefSeq - NM_008744
RefSeq Peptide - NP_032770
swissprot - B0QZL0
swissprot - O09118
Ensembl - ENSMUSG00000020902
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ntn1aENSDARG00000105112Danio rerio
 ntn1bENSDARG00000022531Danio rerio
 NTN1ENSGALG00000023626Gallus gallus
 NTN1ENSG00000065320Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q3UUG6 / Q9R1A3 / Tbc1d24 / Netrin-3 / NTN3* / O00634*ENSMUSG0000003647351
Ntn5 / Q3UQ22 / Netrin-5 / Q8WTR8*ENSMUSG0000007056425
Ush2a / Q2QI47 / usherin / O75445*ENSMUSG0000002660925
Ntng1 / Q8R4G0 / Netrin-G1 / Q9Y2I2*ENSMUSG0000005985725
Ntng2 / Q8R4F1 / Netrin-G2 / Q96CW9*ENSMUSG0000003551324
Megf9 / Q8BH27 / Multiple epidermal growth factor-like domains protein 9 / Q9H1U4* / multiple EGF like domains 9*ENSMUSG0000003927013


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR018933  Netrin module, non-TIMP type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006930 substrate-dependent cell migration, cell extension ISS
 biological_processGO:0007097 nuclear migration IDA
 biological_processGO:0007265 Ras protein signal transduction ISS
 biological_processGO:0007409 axonogenesis IDA
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0030517 negative regulation of axon extension IDA
 biological_processGO:0030879 mammary gland development IGI
 biological_processGO:0032488 Cdc42 protein signal transduction ISS
 biological_processGO:0033564 anterior/posterior axon guidance IMP
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0045773 positive regulation of axon extension IDA
 biological_processGO:0060603 mammary gland duct morphogenesis IGI
 biological_processGO:0098609 cell-cell adhesion IGI
 biological_processGO:2000147 positive regulation of cell motility ISS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005604 basement membrane IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0071944 cell periphery ISO
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
DCC mediated attractive signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-EGFP)Luo/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0002859 abnormal canal fusion "malformed or mistimed fusion of the canal primordia during development" [J:75619]
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0002862 altered righting response "altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0002878 abnormal corticospinal tract "anomaly in the structure or function of the fibers that arise from the cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Acp5tm1Ahdm/Acp5+
Genetic Background: involves: 129S/SvEv

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: En1tm1Gld/En1+,Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0003161 absent lateral semicircular canal 
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0003163 absent posterior semicircular canal 
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Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0003312 abnormal locomotor coordination "reduced ability of an animal to maintain skillful and effective interaction of movements while engaging in locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg,Slit2tm1Matl/Slit2tm1Matl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
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Allelic Composition: En1tm1Gld/En1+,Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

 MP:0003994 abnormal dorsal spinal root morphology "any anomaly, deformity, or malformation of the posterior bundle of nerves emerging from the spinal cord to join with the anterior/ventral nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0008223 absent hippocampal commissure "absence of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0008225 abnormal anterior commissure morphology "any structural anomaly of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0009503 abnormal mammary gland duct morphology "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg,Slit2tm1Matl/Slit2tm1Matl
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

 MP:0009677 abnormal spinal cord dorsal column morphology "any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN-10:0940780577 "Goldberg, S, Clinical Neuroanatomy Made Ridiculously Simple, 3rd edition"]
Show

Allelic Composition: Acp5tm1Ahdm/Acp5+
Genetic Background: involves: 129S/SvEv

 MP:0009681 abnormal pyramidal decussation morphology "any structural anomaly of the bundles of pyramidal fibers that intercross obliquely over the midline at the lower border region of the medulla oblongata" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Acp5tm1Ahdm/Acp5+
Genetic Background: involves: 129S/SvEv

 MP:0009688 abnormal spinal cord central canal morphology "any structural anomaly of the ependyma-lined lumen of the spinal cord that is filled with cerebrospinal fluid; it is patent with the ventricular system of the brain and frequently becomes occluded in aging adults" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0009695 abnormal spinal cord ventral commissure morphology "any structural anomaly of the band of nerve fibers which cross the midline of the spinal cord ventral to the central canal and posterior grey commissure" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0010151 abnormal spinal cord ependymal layer morphology "any structural anomaly of the cellular membrane that lines the central canal of the spinal cord" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Ntn1Gt(IRESBetageo)1Pgr/Ntn1Gt(IRESBetageo)1Pgr
Genetic Background: involves: 129/Sv * C57BL/6 * NMRI

Allelic Composition: Ntn1Gt(ST629)Byg/Ntn1Gt(ST629)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Ntn1tm1.2Tek/Ntn1tm1.2Tek
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c * C57BL/6 * SJL

 MP:0020560 abnormal pontine nuclei morphology "any structural anomaly of nuclei in the basal pons, intermingled among the descending axons from the cortex, that receive neocortcial input and give rise to many axons that cross the midline to enter the contralateral cerebellum" [UBERON:0002151]
Show

Allelic Composition: Ntf5tm1Jae/Ntf5tm1Jae
Genetic Background: involves: 129S4/SvJae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059921 Unc5c / O08747 / unc-5 netrin receptor C / O95185*  / complex
 ENSMUSG00000043733 P35235 / Ptpn11 / Tyrosine-protein phosphatase non-receptor type 11 / Q06124* / protein tyrosine phosphatase, non-receptor type 11*  / reaction / complex
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000050272 Dscam / Q9ERC8 / Down syndrome cell adhesion molecule homolog / O60469* / DS cell adhesion molecule*  / complex / reaction
 ENSMUSG00000032128 Robo3 / roundabout guidance receptor 3 / Q96MS0*  / reaction / complex
 ENSMUSG00000040749 Siah1b / siah E3 ubiquitin protein ligase 1B / SIAH1* / Q8IUQ4* / siah E3 ubiquitin protein ligase 1*  / reaction / complex
 ENSMUSG00000036432 Siah2 / Q06986 / siah E3 ubiquitin protein ligase 2 / O43255*  / reaction / complex
 ENSMUSG00000036840 Siah1a / P61092 / E3 ubiquitin-protein ligase SIAH1A / SIAH1* / Q8IUQ4* / siah E3 ubiquitin protein ligase 1*  / complex / reaction
 ENSMUSG00000022263 Trio / Q0KL02 / Triple functional domain protein / O75962* / trio Rho guanine nucleotide exchange factor*  / reaction / complex
 ENSMUSG00000058325 Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*  / reaction / complex
 ENSMUSG00000060534 Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*  / complex / reaction
 ENSMUSG00000017781 P53810 / Pitpna / phosphatidylinositol transfer protein, alpha / Q00169*  / reaction / complex
 ENSMUSG00000032475 Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*  / reaction / complex






 

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