ENSDARG00000105112


Danio rerio

Features
Gene ID: ENSDARG00000105112
  
Biological name :ntn1a
  
Synonyms : netrin 1a / ntn1a
  
Possible biological names infered from orthology : netrin 1 / NTN1 / O09118 / O95631
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 19804048
Gene end: 19926657
  
Corresponding Affymetrix probe sets: Dr.21069.1.S1_s_at (Zebrafish Array)   Dr.25619.1.A1_at (Zebrafish Array)   Dr.545.1.S1_at (Zebrafish Array)   NM_131029_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000137325
Ensembl peptide - ENSDARP00000133934
NCBI entrez gene - 30227     See in Manteia.
RefSeq - NM_131029
RefSeq Peptide - NP_571104
swissprot - A0A0R4IN40
swissprot - O42140
ZFIN ID - ZDB-GENE-990415-169
Ensembl - ENSDARG00000105112
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NTN1ENSGALG00000023626Gallus gallus
 NTN1ENSG00000065320Homo sapiens
 Ntn1ENSMUSG00000020902Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ntn1b / netrin 1b / NTN1* / O09118* / O95631* / netrin 1*ENSDARG0000002253186
ntn2 / netrin 2 / NTN3* / O00634* / Q3UUG6* / Q9R1A3* / Tbc1d24* / netrin 3*ENSDARG0000007674869
ntn5 / netrin 5 / Q3UQ22* / Q8WTR8*ENSDARG0000003642242
ntng1a / netrin g1a / NTNG1* / Q8R4G0* / Q9Y2I2* / netrin G1*ENSDARG0000001497325
ush2a / Usher syndrome 2A (autosomal recessive, mild) / O75445* / Q2QI47* / usherin*ENSDARG0000002948225
ntng2a / netrin g2a / NTNG2* / Q8R4F1* / Q96CW9* / netrin G2*ENSDARG0000007736722
vav3b / vav 3 guanine nucleotide exchange factor b / NTNG1* / Q8R4G0* / Q9Y2I2* / netrin G1*ENSDARG0000007371320
ntng2b / netrin g2b / NTNG2* / Q8R4F1* / Q96CW9* / netrin G2*ENSDARG0000008710011
si:dkey-220k22.1ENSDARG0000003547110
si:ch211-158d24.2ENSDARG0000007853610
si:ch211-57i17.5 / MEGF9* / Q8BH27* / Q9H1U4* / multiple EGF like domains 9* / Multiple epidermal growth factor-like domains protein 9 *ENSDARG000000413750


Protein motifs (from Interpro)
Interpro ID Name
 IPR001134  Netrin domain
 IPR002049  Laminin EGF domain
 IPR008211  Laminin, N-terminal
 IPR008979  Galactose-binding-like domain superfamily
 IPR008993  Tissue inhibitor of metalloproteinases-like, OB-fold
 IPR018933  Netrin module, non-TIMP type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003146 heart jogging IMP
 biological_processGO:0016358 dendrite development IGI
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0021952 central nervous system projection neuron axonogenesis IGI
 biological_processGO:0021960 anterior commissure morphogenesis IMP
 biological_processGO:0030516 regulation of axon extension IGI
 biological_processGO:0030878 thyroid gland development IMP
 biological_processGO:0033564 anterior/posterior axon guidance IMP
 biological_processGO:0035908 ventral aorta development IMP
 biological_processGO:0048665 neuron fate specification IMP
 biological_processGO:0048846 axon extension involved in axon guidance IMP
 biological_processGO:0061626 pharyngeal arch artery morphogenesis IMP
 biological_processGO:0071678 olfactory bulb axon guidance IMP
 cellular_componentGO:0005576 extracellular region IEA


Pathways (from Reactome)
Pathway description
Netrin-1 signaling
DCC mediated attractive signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000604 ventral aorta ventral aorta morphology , abnormal
ventral aorta separated from bulbus arteriosus , abnormal
Show

 ZFA:0000671 horizontal myoseptum horizontal myoseptum lacks parts or has fewer parts of type RoP motor neuron axon, abnormal
horizontal myoseptum lacks parts or has fewer parts of type motor neuron axon, abnormal
Show

 ZFA:0000673 hypobranchial artery hypobranchial artery dysplastic , abnormal
hypobranchial artery morphology , abnormal
Show

 ZFA:0001072 thyroid follicle thyroid follicle cell decreased amount , abnormal
thyroid follicle mislocalised , abnormal
thyroid follicle position , abnormal
Show

 ZFA:0001081 thyroid primordium thyroid primordium morphology , abnormal
thyroid primordium mislocalised , abnormal
thyroid primordium distended , abnormal
Show

 ZFA:0001094 whole organism whole organism lacks parts or has fewer parts of type parachordal vessel , abnormal
whole organism has fewer parts of type intersegmental vessel , abnormal
whole organism lacks parts or has fewer parts of type intersegmental vessel , abnormal
whole organism lacks all parts of type dorsal longitudinal anastomotic vessel , abnormal
whole organism lacks all parts of type parachordal vessel , abnormal
Show

 ZFA:0001108 anterior commissure anterior commissure axon extension process quality , abnormal
Show

 ZFA:0001285 intersegmental vessel intersegmental vessel disorganized , abnormal
intersegmental vessel endothelial cell decreased amount , abnormal
Show

 ZFA:0001657 supraoptic tract supraoptic tract axon extension process quality , abnormal
Show

 ZFA:0005003 pharyngeal vasculature pharyngeal vasculature morphology , abnormal
Show

 ZFA:0005004 aortic arch aortic arch absent , abnormal
aortic arch morphology , abnormal
aortic arch hypoplastic , abnormal
Show

 ZFA:0005024 trunk vasculature trunk vasculature lacks all parts of type parachordal vessel , abnormal
Show

 ZFA:0005034 parachordal vessel parachordal vessel morphology , abnormal
parachordal vessel incomplete structure , abnormal
parachordal vessel immature , abnormal
parachordal vessel venous endothelial cell migration involved in lymph vessel development arrested , abnormal
Show

 ZFA:0005110 thoracic duct thoracic duct aplastic , abnormal
Show

 ZFA:0005181 VaP motor neuron VaP motor neuron axon protruding into horizontal myoseptum , abnormal
VaP motor neuron axon increased branchiness , abnormal
VaP motor neuron axon protruding into muscle pioneer , abnormal
Show

 ZFA:0007001 dorso-rostral cluster dorso-rostral cluster neuron projection physical object quality , abnormal
dorso-rostral cluster neuron projection mislocalised dorsally , abnormal
dorso-rostral cluster axon extension process quality , abnormal
dorso-rostral cluster neuron projection mislocalised , abnormal
dorso-rostral cluster neuron projection misrouted , abnormal
Show

 ZFA:0009125 olfactory receptor cell olfactory receptor cell axon position , abnormal
olfactory receptor cell axon posterior to olfactory bulb , abnormal
olfactory receptor cell axon attached to medial protoglomerulus , abnormal
olfactory receptor cell axon attached to dorsal zone olfactory bulb , abnormal
olfactory receptor cell axon attached to ventral zone olfactory bulb , abnormal
olfactory receptor cell axon attached to anteromedial zone olfactory bulb , abnormal
Show

 ZFA:0009239 efferent neuron efferent neuron dendrite mislocalised , abnormal
efferent neuron dendrite decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000025319 fynb / F1RDG9 / FYN proto-oncogene, Src family tyrosine kinase b / FYN* / P39688* / P06241* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSDARG00000019426 trioa / trio Rho guanine nucleotide exchange factor a / TRIO* / Q0KL02* / O75962* / Triple functional domain protein * / trio Rho guanine nucleotide exchange factor*  / complex / reaction
 ENSDARG00000008107 src / Q1JPZ3 / v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog / P12931* / P05480* / Neuronal proto-onco tyrosine-protein kinase Src * / SRC proto-oncogene, non-receptor tyr...  / reaction / complex
 ENSDARG00000011370 fyna / Q6EWH2 / FYN proto-oncogene, Src family tyrosine kinase a / FYN* / P06241* / P39688* / Tyrosine-protein kinase Fyn * / FYN proto-oncogene, Src family tyrosine kinase*  / reaction / complex
 ENSDARG00000044573 cdc42 / cell division cycle 42 / P60766* / P60953* / Cell division control *  / reaction / complex
 ENSDARG00000030871 siah1 / siah E3 ubiquitin protein ligase 1 / Siah1b* / Q8IUQ4* / P61092* / Siah1a* / siah E3 ubiquitin protein ligase 1B* / E3 ubiquitin-protein ligase SIAH1A *  / reaction / complex
 ENSDARG00000044381 siah2l / seven in absentia homolog 2 (Drosophila)-like / SIAH2* / SIAH3* / Q06986* / O43255* / Q8IW03* / siah E3 ubiquitin protein ligase 2* / siah E3 ubiquitin protein ligase family member 3*  / reaction / complex
 ENSDARG00000075369 nck1b / NCK adaptor protein 1b / NCK1* / P16333* / Q99M51* / NCK adaptor protein 1* / Cytoplasmic protein NCK1 *  / reaction / complex






 

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