ENSMUSG00000032475


Mus musculus

Features
Gene ID: ENSMUSG00000032475
  
Biological name :Nck1
  
Synonyms : Cytoplasmic protein NCK1 / Nck1 / Q99M51
  
Possible biological names infered from orthology : NCK adaptor protein 1 / P16333
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E3.3
Gene start: 100492293
Gene end: 100546134
  
Corresponding Affymetrix probe sets: 10596043 (MoGene1.0st)   1421487_a_at (Mouse Genome 430 2.0 Array)   1424543_at (Mouse Genome 430 2.0 Array)   1447271_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000140143
Ensembl peptide - ENSMUSP00000140971
Ensembl peptide - ENSMUSP00000108495
Ensembl peptide - ENSMUSP00000112221
NCBI entrez gene - 17973     See in Manteia.
MGI - MGI:109601
RefSeq - NM_010878
RefSeq - XM_006510840
RefSeq - NM_001324530
RefSeq Peptide - NP_001311459
RefSeq Peptide - NP_035008
swissprot - A0A087WQD1
swissprot - Q8BH99
swissprot - Q99M51
swissprot - A0A087WSB1
Ensembl - ENSMUSG00000032475
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nck1aENSDARG00000074262Danio rerio
 nck1bENSDARG00000075369Danio rerio
 NCK1ENSG00000158092Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*ENSMUSG0000006687768
Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*ENSMUSG0000004235115
Grap / Q9CX99 / GRB2-related adapter protein / GRAPL* / Q13588* / Q8TC17* / GRB2-related adaptor protein* / GRB2 related adaptor protein like*ENSMUSG0000000483715
Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*ENSMUSG0000005992314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR001452  SH3 domain
 IPR017304  Cytoplasmic protein NCK
 IPR035562  Nck1, SH3 domain 1
 IPR035564  Nck1, SH3 domain 2
 IPR035565  Nck1, SH3 domain 3
 IPR035882  Nck1, SH2 domain
 IPR036028  SH3-like domain superfamily
 IPR036860  SH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation IEA
 biological_processGO:0006469 negative regulation of protein kinase activity IEA
 biological_processGO:0006930 substrate-dependent cell migration, cell extension IGI
 biological_processGO:0007015 actin filament organization IMP
 biological_processGO:0010976 positive regulation of neuron projection development IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0030032 lamellipodium assembly IMP
 biological_processGO:0030334 regulation of cell migration IGI
 biological_processGO:0030838 positive regulation of actin filament polymerization IEA
 biological_processGO:0033137 negative regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0036493 positive regulation of translation in response to endoplasmic reticulum stress IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042110 T cell activation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046627 negative regulation of insulin receptor signaling pathway IEA
 biological_processGO:0048013 ephrin receptor signaling pathway IMP
 biological_processGO:0051707 response to other organism IMP
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0070262 peptidyl-serine dephosphorylation IEA
 biological_processGO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
 biological_processGO:1903676 positive regulation of cap-dependent translational initiation IEA
 biological_processGO:1903679 positive regulation of cap-independent translational initiation IEA
 biological_processGO:1903898 negative regulation of PERK-mediated unfolded protein response IEA
 biological_processGO:1903912 negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IEA
 biological_processGO:1990441 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress IEA
 cellular_componentGO:0000164 protein phosphatase type 1 complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0012506 vesicle membrane IDA
 molecular_functionGO:0004860 protein kinase inhibitor activity IEA
 molecular_functionGO:0005070 SH3/SH2 adaptor activity IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0030971 receptor tyrosine kinase binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0046875 ephrin receptor binding IPI
 molecular_functionGO:0060090 molecular adaptor activity IEA
 molecular_functionGO:0071074 eukaryotic initiation factor eIF2 binding IPI


Pathways (from Reactome)
Pathway description
Downstream signal transduction
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
Nephrin family interactions
DCC mediated attractive signaling
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000928 incomplete cephalic closure "arrest of the fusion of the cephalic neural folds" [J:12622]
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctnnb1tm3Wbm/Ctnnb1tm3Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002199 abnormal brain commissure morphology "absent or defective structure in a bundle of nerve fibers connecting the two brain hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0002961 abnormal axon guidance "defect in the signaling mechanisms that allow precise navigation and connections of axonal growth cones to effector tissues " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0003880 abnormal central pattern generator function "anomalous function of the neural networks that produce rhythmic patterned output without sensory input and underlie rhythmic motor patterns" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:101019]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0004557 dilated allantois "an expansion in the volume of the fetal membrane which contributes to the formation of the umbilical cord and placental blood vessels, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0004712 notochord degeneration "retrogressive pathologic change of the axial fibrocellular cord in embryos around which develops the vertebral primordia (prior to normal differentiation of this tissue into the vertebral column tissues)" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008059 abnormal podocyte foot process morphology "any structural anomaly of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0008139 fused podocyte foot processes "coalescence of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries " [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0008503 abnormal spinal cord gray matter morphology "any structural anomaly of the regions of the spinal cord that are largely or entirely composed of nerve cell bodies and their dendrites and some supportive tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0009677 abnormal spinal cord dorsal column morphology "any structural anomaly of the wedge-shaped fiber bundle of white matter in the dorsomedial side of the spinal cord that is made up of the fasciculus gracilis and fasciculus cuneatus; it is part of the ascending posterior column-medial lemniscus pathway that is important for well-localized fine touch and conscious proprioception" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", ISBN-10:0940780577 "Goldberg, S, Clinical Neuroanatomy Made Ridiculously Simple, 3rd edition"]
Show

Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nck1tm1Paw/Nck1tm1Paw,Nck2tm1Paw/Nck2tm3Paw,Tg(Nes-cre)1Kln/0
Genetic Background: involves: C57BL/6 * SJL

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Bmi1tm1Brn/Bmi1+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011402 renal cast "any of the various casts formed from gelled protein precipitated in the distal convoluted tubules and collecting ducts of nephrons and molded to the tubular or duct lumen which dislodge and pass into the urine; types named for their constituent material include acellular casts (e.g. granular, hyaline, waxy, or fatty casts) and cellular casts (e.g. red or white blood cell casts)" [MGI:anna]
Show

Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

 MP:0011856 abnormal glomerular filtration barrier function "anomaly in the function of the highly specialized blood filtration interface that displays a high conductance to small and midsized solutes in plasma but retains relative impermeability to macromolecules; its integrity is maintained by physicochemical and signalling interplay among its three core constituents -- the fenestrated endothelium of the glomerular capillaries, the glomerular basement membrane, and the filtration slits of the visceral epithelial cell (podocyte); the barrier permits the passage of water, ions, and small molecules from the bloodstream into the Bowman s space and prevents the loss of large and/or negatively charged proteins (e.g. serum albumin) from blood into urine" [MGI:anna]
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Allelic Composition: Tex14tm1Zuk/Tex14tm1Zuk
Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction / complex
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / complex / reaction
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction / complex
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction / complex
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000022263 Trio / Q0KL02 / Triple functional domain protein / O75962* / trio Rho guanine nucleotide exchange factor*  / reaction / complex
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / complex / reaction
 ENSMUSG00000058325 Dock1 / Q8BUR4 / Dedicator of cytokinesis protein 1 / Q14185* / dedicator of cytokinesis 1*  / reaction / complex
 ENSMUSG00000025856 Pdgfa / platelet derived growth factor subunit A / P04085*  / complex / reaction
 ENSMUSG00000029231 P26618 / Pdgfra / Mus musculus platelet derived growth factor receptor, alpha polypeptide (Pdgfra), transcript variant 4, mRNA. / P16234* / platelet derived growth factor receptor alpha*  / reaction / complex
 ENSMUSG00000060534 Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / reaction / complex
 ENSMUSG00000024620 Pdgfrb / platelet-derived growth factor receptor beta isoform 2 / P09619* / platelet derived growth factor receptor beta*  / complex / reaction
 ENSMUSG00000000489 Pdgfb / platelet derived growth factor, B polypeptide / P01127* / platelet derived growth factor subunit B*  / complex / reaction
 ENSMUSG00000041734 Q80W68 / Kirrel / Kin of IRRE-like protein 1 / Q96J84* / KIRREL1* / kirre like nephrin family adhesion molecule 1*  / complex / reaction
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / reaction / complex
 ENSMUSG00000006649 Nphs1 / Q9QZS7 / Nephrin / O60500* / NPHS1, nephrin*  / complex / reaction
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / complex / reaction
 ENSMUSG00000031165 Was / P70315 / Wiskott-Aldrich syndrome / P42768*  / complex / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / complex / reaction
 ENSMUSG00000020902 Ntn1 / O09118 / Netrin-1 / O95631*  / reaction / complex






 

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