ENSMUSG00000022263


Mus musculus

Features
Gene ID: ENSMUSG00000022263
  
Biological name :Trio
  
Synonyms : Q0KL02 / Trio / Triple functional domain protein
  
Possible biological names infered from orthology : O75962 / trio Rho guanine nucleotide exchange factor
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: B1
Gene start: 27730651
Gene end: 28025848
  
Corresponding Affymetrix probe sets: 10427928 (MoGene1.0st)   10427991 (MoGene1.0st)   1433745_at (Mouse Genome 430 2.0 Array)   1438099_at (Mouse Genome 430 2.0 Array)   1439552_at (Mouse Genome 430 2.0 Array)   1442751_at (Mouse Genome 430 2.0 Array)   1446593_at (Mouse Genome 430 2.0 Array)   1454711_at (Mouse Genome 430 2.0 Array)   1457492_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000154789
Ensembl peptide - ENSMUSP00000087714
Ensembl peptide - ENSMUSP00000153890
Ensembl peptide - ENSMUSP00000154309
Ensembl peptide - ENSMUSP00000154458
Ensembl peptide - ENSMUSP00000154608
Ensembl peptide - ENSMUSP00000154653
NCBI entrez gene - 223435     See in Manteia.
MGI - MGI:1927230
RefSeq - XM_006520054
RefSeq - XM_006520053
RefSeq - NM_001081302
RefSeq - XM_006520050
RefSeq - XM_006520051
RefSeq - XM_006520052
RefSeq Peptide - NP_001074771
swissprot - Q0KL02
Ensembl - ENSMUSG00000022263
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 trioaENSDARG00000019426Danio rerio
 triobENSDARG00000000370Danio rerio
 TRIOENSGALG00000031495Gallus gallus
 TRIOENSG00000038382Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kalrn / A2CG49 / Kalirin / O60229* / kalirin RhoGEF kinase*ENSMUSG0000006175141
Arhgef25 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 25 (Arhgef25), transcript variant 3, mRNA. / Q86VW2* / Rho guanine nucleotide exchange factor 25*ENSMUSG0000001946710
Mcf2l / MCF.2 cell line derived transforming sequence like / O15068*ENSMUSG0000003144210
Mcf2 / MCF.2 cell line derived transforming sequence / P10911*ENSMUSG000000311399
Plekhg1 / pleckstrin homology and RhoGEF domain containing G1 / Q9ULL1*ENSMUSG000000406247
Q4VAC9 / Plekhg3 / Pleckstrin homology domain-containing family G member 3 / A1L390* / pleckstrin homology and RhoGEF domain containing G3*ENSMUSG000000526096
Plekhg2 / pleckstrin homology and RhoGEF domain containing G2 / Q9H7P9*ENSMUSG000000375525


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000719  Protein kinase domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR002017  Spectrin repeat
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR018159  Spectrin/alpha-actinin
 IPR028570  Triple functional domain protein
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036179  Immunoglobulin-like domain superfamily
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0045599 negative regulation of fat cell differentiation IMP
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (q) signalling events
G alpha (12/13) signalling events
DCC mediated attractive signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000729 abnormal myogenesis "anomaly in embryonic formation of muscle cells or fibers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0000774 reduced brain size "smaller appearance of the brain" [J:35802]
Show

Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
Show

Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
Show

Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adam17tm1.1Srj/Adam17tm1.1Srj
Genetic Background: involves: 129S/SvEv

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0004279 abnormal rostral migratory stream morphology "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0009951 abnormal olfactory bulb mitral cell layer morphology 
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0009964 abnormal cerebellum lobule morphology "any structural anomaly of the ten gyri of the cerebellar cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0009977 abnormal cerebellar granule cell migration "defective or impaired movement of cerebellar granule cell neurons from the germinal zone into the granule cell layer of the cerebellum during development of the cerebellar cortex" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0010387 abnormal Bergmann glial cell morphology "any structural anomaly of one or more astrocyte-type glia cells associated with Purkinje cells in the cerebellum" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Tg(Nes-cre)1Kln/0,Triotm1Mzhu/Triotm1Mzhu
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000024639 Gnaq / P21279 / guanine nucleotide binding protein, alpha q polypeptide / P50148* / G protein subunit alpha q*  / reaction / complex
 ENSMUSG00000024697 Gna14 / P30677 / guanine nucleotide binding protein, alpha 14 / O95837* / G protein subunit alpha 14*  / reaction / complex
 ENSMUSG00000034792 Gna15 / P30678 / guanine nucleotide binding protein, alpha 15 / P30679* / G protein subunit alpha 15*  / reaction / complex
 ENSMUSG00000034781 Gna11 / P21278 / guanine nucleotide binding protein, alpha 11 / P29992* / G protein subunit alpha 11*  / reaction / complex
 ENSMUSG00000029684 Wasl / Q91YD9 / Wiskott-Aldrich syndrome-like (human) / O00401* / Wiskott-Aldrich syndrome like*  / complex / reaction
 ENSMUSG00000060534 Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*  / reaction / complex
 ENSMUSG00000032475 Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*  / reaction / complex
 ENSMUSG00000020902 Ntn1 / O09118 / Netrin-1 / O95631*  / complex / reaction
 ENSMUSG00000022607 Ptk2 / P34152 / PTK2 protein tyrosine kinase 2 / Q05397* / protein tyrosine kinase 2*  / reaction / complex
 ENSMUSG00000027646 Src / P05480 / Neuronal proto-onco tyrosine-protein kinase Src / P12931* / SRC proto-oncogene, non-receptor tyrosine kinase*  / complex / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex






 

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