ENSMUSG00000019467


Mus musculus

Features
Gene ID: ENSMUSG00000019467
  
Biological name :Arhgef25
  
Synonyms : Arhgef25 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 25 (Arhgef25), transcript variant 3, mRNA.
  
Possible biological names infered from orthology : Q86VW2 / Rho guanine nucleotide exchange factor 25
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: D3
Gene start: 127182525
Gene end: 127190083
  
Corresponding Affymetrix probe sets: 10373073 (MoGene1.0st)   1419978_s_at (Mouse Genome 430 2.0 Array)   1426855_at (Mouse Genome 430 2.0 Array)   1449687_at (Mouse Genome 430 2.0 Array)   1449688_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126339
Ensembl peptide - ENSMUSP00000019611
Ensembl peptide - ENSMUSP00000151325
Ensembl peptide - ENSMUSP00000152503
Ensembl peptide - ENSMUSP00000151876
Ensembl peptide - ENSMUSP00000151801
Ensembl peptide - ENSMUSP00000151492
NCBI entrez gene - 52666     See in Manteia.
MGI - MGI:1277173
RefSeq - XM_006513881
RefSeq - NM_001166413
RefSeq - NM_001358557
RefSeq - NM_001358558
RefSeq - NM_028027
RefSeq - XM_006513878
RefSeq - XM_006513879
RefSeq - XM_006513880
RefSeq Peptide - NP_001345487
RefSeq Peptide - NP_082303
RefSeq Peptide - NP_001159885
RefSeq Peptide - NP_001345486
swissprot - A0A1Y7VNM7
swissprot - A0A1W2P813
swissprot - A0A1W2P7S3
swissprot - A0A1W2P718
swissprot - G5E825
swissprot - A0A0R4J211
swissprot - A0A1W2P6R9
Ensembl - ENSMUSG00000019467
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arhgef25bENSDARG00000014465Danio rerio
 BX539336.1ENSDARG00000100606Danio rerio
 Q86VW2ENSG00000240771Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trio / Q0KL02 / Triple functional domain protein / O75962* / trio Rho guanine nucleotide exchange factor*ENSMUSG0000002226351
Mcf2l / MCF.2 cell line derived transforming sequence like / O15068*ENSMUSG0000003144221
Plekhg1 / pleckstrin homology and RhoGEF domain containing G1 / Q9ULL1*ENSMUSG0000004062420
Q4VAC9 / Plekhg3 / Pleckstrin homology domain-containing family G member 3 / A1L390* / pleckstrin homology and RhoGEF domain containing G3*ENSMUSG0000005260919
Mcf2 / MCF.2 cell line derived transforming sequence / P10911*ENSMUSG0000003113919
Plekhg2 / pleckstrin homology and RhoGEF domain containing G2 / Q9H7P9*ENSMUSG0000003755218
Kalrn / A2CG49 / Kalirin / O60229* / kalirin RhoGEF kinase*ENSMUSG000000617516


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR030738  Rho guanine nucleotide exchange factor 25
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sox9tm1Gsr/Sox9tm1Gsr,Tg(Col2a1/Acan-rtTA,tetO-cre)#Vlf/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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