ENSMUSG00000031442


Mus musculus

Features
Gene ID: ENSMUSG00000031442
  
Biological name :Mcf2l
  
Synonyms : MCF.2 cell line derived transforming sequence like / Mcf2l
  
Possible biological names infered from orthology : O15068
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: A1.1
Gene start: 12873806
Gene end: 13020905
  
Corresponding Affymetrix probe sets: 10570236 (MoGene1.0st)   1434140_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000114758
Ensembl peptide - ENSMUSP00000106503
Ensembl peptide - ENSMUSP00000116731
Ensembl peptide - ENSMUSP00000134147
Ensembl peptide - ENSMUSP00000133776
Ensembl peptide - ENSMUSP00000133577
Ensembl peptide - ENSMUSP00000123434
Ensembl peptide - ENSMUSP00000122792
Ensembl peptide - ENSMUSP00000120946
Ensembl peptide - ENSMUSP00000118540
Ensembl peptide - ENSMUSP00000093108
Ensembl peptide - ENSMUSP00000096528
Ensembl peptide - ENSMUSP00000106490
Ensembl peptide - ENSMUSP00000106491
Ensembl peptide - ENSMUSP00000106495
Ensembl peptide - ENSMUSP00000106497
Ensembl peptide - ENSMUSP00000106500
NCBI entrez gene - 17207     See in Manteia.
MGI - MGI:103263
RefSeq - XM_017312595
RefSeq - XM_006508706
RefSeq - XM_006508707
RefSeq - XM_006508708
RefSeq - XM_006508709
RefSeq - XM_006508710
RefSeq - XM_006508711
RefSeq - XM_006508712
RefSeq - XM_006508713
RefSeq - XM_006508714
RefSeq - XM_006508715
RefSeq - XM_006508716
RefSeq - XM_006508717
RefSeq - XM_006508718
RefSeq - XM_006508719
RefSeq - XM_006508720
RefSeq - XM_006508721
RefSeq - XM_006508722
RefSeq - XM_006508723
RefSeq - XM_011242040
RefSeq - XM_017312593
RefSeq - NM_001159485
RefSeq - NM_001159486
RefSeq - NM_178076
RefSeq Peptide - NP_835177
RefSeq Peptide - NP_001152958
RefSeq Peptide - NP_001152957
swissprot - E9PY12
swissprot - E9PXE2
swissprot - E9PXE1
swissprot - D3Z3S7
swissprot - F6UKC6
swissprot - F6VR53
swissprot - F6WPM5
swissprot - E9QPM7
swissprot - F7BZ65
swissprot - G3UX72
swissprot - G3UXP9
swissprot - G3UYM8
swissprot - D3YUF4
swissprot - D3YUF3
swissprot - F6ZFQ8
swissprot - E9Q863
swissprot - E9PY13
Ensembl - ENSMUSG00000031442
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcf2laENSDARG00000075859Danio rerio
 mcf2lbENSDARG00000076480Danio rerio
 MCF2LENSGALG00000016834Gallus gallus
 MCF2LENSG00000126217Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mcf2 / MCF.2 cell line derived transforming sequence / P10911*ENSMUSG0000003113938
Trio / Q0KL02 / Triple functional domain protein / O75962* / trio Rho guanine nucleotide exchange factor*ENSMUSG0000002226327
Plekhg1 / pleckstrin homology and RhoGEF domain containing G1 / Q9ULL1*ENSMUSG0000004062415
Kalrn / A2CG49 / Kalirin / O60229* / kalirin RhoGEF kinase*ENSMUSG0000006175113
Q4VAC9 / Plekhg3 / Pleckstrin homology domain-containing family G member 3 / A1L390* / pleckstrin homology and RhoGEF domain containing G3*ENSMUSG0000005260913
Plekhg2 / pleckstrin homology and RhoGEF domain containing G2 / Q9H7P9*ENSMUSG0000003755212
Arhgef25 / Mus musculus Rho guanine nucleotide exchange factor (GEF) 25 (Arhgef25), transcript variant 3, mRNA. / Q86VW2* / Rho guanine nucleotide exchange factor 25*ENSMUSG0000001946711


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR002017  Spectrin repeat
 IPR011993  PH-like domain superfamily
 IPR018159  Spectrin/alpha-actinin
 IPR035532  DBS, SH3 domain
 IPR035534  DBS, PH domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001566 hyperphosphatemia "abnormally high concentrations of phosphates in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm1a(EUCOMM)Hmgu/Hprttm1a(EUCOMM)Hmgu
Genetic Background: C57BL/6N-Hprttm1a(EUCOMM)Hmgu/Ieg

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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