ENSG00000126217


Homo sapiens

Features
Gene ID: ENSG00000126217
  
Biological name :MCF2L
  
Synonyms : MCF.2 cell line derived transforming sequence like / MCF2L / O15068
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 13
Strand: 1
Band: q34
Gene start: 112894378
Gene end: 113099739
  
Corresponding Affymetrix probe sets: 1552743_at (Human Genome U133 Plus 2.0 Array)   1559427_at (Human Genome U133 Plus 2.0 Array)   1563808_at (Human Genome U133 Plus 2.0 Array)   1563809_a_at (Human Genome U133 Plus 2.0 Array)   212935_at (Human Genome U133 Plus 2.0 Array)   220464_at (Human Genome U133 Plus 2.0 Array)   239636_at (Human Genome U133 Plus 2.0 Array)   35147_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000405996
Ensembl peptide - ENSP00000404422
Ensembl peptide - ENSP00000407392
Ensembl peptide - ENSP00000473071
Ensembl peptide - ENSP00000471913
Ensembl peptide - ENSP00000440374
Ensembl peptide - ENSP00000411315
Ensembl peptide - ENSP00000261963
Ensembl peptide - ENSP00000364747
Ensembl peptide - ENSP00000364754
Ensembl peptide - ENSP00000364758
Ensembl peptide - ENSP00000380212
Ensembl peptide - ENSP00000380216
Ensembl peptide - ENSP00000380219
Ensembl peptide - ENSP00000380225
Ensembl peptide - ENSP00000380230
Ensembl peptide - ENSP00000386551
Ensembl peptide - ENSP00000392953
Ensembl peptide - ENSP00000395707
Ensembl peptide - ENSP00000395978
Ensembl peptide - ENSP00000397285
Ensembl peptide - ENSP00000398383
NCBI entrez gene - 23263     See in Manteia.
OMIM - 609499
RefSeq - XM_017020499
RefSeq - NM_001112732
RefSeq - NM_001320815
RefSeq - NM_001320816
RefSeq - NM_001320817
RefSeq - NM_024979
RefSeq - XM_011537482
RefSeq - XM_011537483
RefSeq - XM_011537484
RefSeq - XM_011537485
RefSeq - XM_011537486
RefSeq - XM_011537487
RefSeq - XM_011537488
RefSeq - XM_011537490
RefSeq - XM_011537491
RefSeq - XM_017020493
RefSeq - XM_017020494
RefSeq - XM_017020495
RefSeq - XM_017020496
RefSeq - XM_017020497
RefSeq - XM_017020498
RefSeq Peptide - NP_001307744
RefSeq Peptide - NP_001307745
RefSeq Peptide - NP_001307746
RefSeq Peptide - NP_079255
RefSeq Peptide - NP_001106203
swissprot - A2A3H1
swissprot - F8WBK7
swissprot - H0Y4M6
swissprot - H0Y519
swissprot - H0Y7A3
swissprot - H3BLT1
swissprot - H7BYP9
swissprot - H7C275
swissprot - H7C2S1
swissprot - M0R1J7
swissprot - M0R393
swissprot - X6RE72
swissprot - A2A3G7
swissprot - O15068
swissprot - B7ZBR9
swissprot - A2A640
swissprot - A2A639
Ensembl - ENSG00000126217
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mcf2laENSDARG00000075859Danio rerio
 mcf2lbENSDARG00000076480Danio rerio
 MCF2LENSGALG00000016834Gallus gallus
 Mcf2lENSMUSG00000031442Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MCF2L2 / Q86YR7 / MCF.2 cell line derived transforming sequence-like 2ENSG0000005352441
MCF2 / P10911 / MCF.2 cell line derived transforming sequenceENSG0000010197740
TRIO / O75962 / trio Rho guanine nucleotide exchange factorENSG0000003838228
A1L390 / PLEKHG3 / pleckstrin homology and RhoGEF domain containing G3ENSG0000012682214
Q9ULL1 / PLEKHG1 / pleckstrin homology and RhoGEF domain containing G1ENSG0000012027814
KALRN / O60229 / kalirin RhoGEF kinaseENSG0000016014513
Q9H7P9 / PLEKHG2 / pleckstrin homology and RhoGEF domain containing G2ENSG0000009092412
Q86VW2 / ARHGEF25 / Rho guanine nucleotide exchange factor 25ENSG0000024077111


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001331  Guanine-nucleotide dissociation stimulator, CDC24, conserved site
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR002017  Spectrin repeat
 IPR011993  PH-like domain superfamily
 IPR018159  Spectrin/alpha-actinin
 IPR035532  DBS, SH3 domain
 IPR035534  DBS, PH domain
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005615 extracellular space HDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0035091 phosphatidylinositol binding IDA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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