ENSG00000160145


Homo sapiens

Features
Gene ID: ENSG00000160145
  
Biological name :KALRN
  
Synonyms : kalirin RhoGEF kinase / KALRN / O60229
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q21.1
Gene start: 124080023
Gene end: 124726325
  
Corresponding Affymetrix probe sets: 205635_at (Human Genome U133 Plus 2.0 Array)   206078_at (Human Genome U133 Plus 2.0 Array)   227750_at (Human Genome U133 Plus 2.0 Array)   230596_at (Human Genome U133 Plus 2.0 Array)   232717_at (Human Genome U133 Plus 2.0 Array)   232756_at (Human Genome U133 Plus 2.0 Array)   236651_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000400064
Ensembl peptide - ENSP00000395236
Ensembl peptide - ENSP00000402950
Ensembl peptide - ENSP00000487487
Ensembl peptide - ENSP00000418611
Ensembl peptide - ENSP00000240874
Ensembl peptide - ENSP00000291478
Ensembl peptide - ENSP00000346122
Ensembl peptide - ENSP00000353109
NCBI entrez gene - 8997     See in Manteia.
OMIM - 604605
RefSeq - XM_017007435
RefSeq - XM_006713810
RefSeq - XM_006713811
RefSeq - XM_006713812
RefSeq - XM_006713813
RefSeq - XM_006713814
RefSeq - XM_006713815
RefSeq - XM_011513279
RefSeq - XM_011513280
RefSeq - XM_011513281
RefSeq - XM_011513283
RefSeq - XM_011513285
RefSeq - XM_017007429
RefSeq - XM_017007430
RefSeq - XM_017007431
RefSeq - XM_017007432
RefSeq - XM_017007433
RefSeq - XM_017007434
RefSeq - NM_001024660
RefSeq - NM_001322988
RefSeq - NM_001322989
RefSeq - NM_001322990
RefSeq - NM_001322991
RefSeq - NM_001322992
RefSeq - NM_001322993
RefSeq - NM_003947
RefSeq - NM_007064
RefSeq Peptide - NP_001309917
RefSeq Peptide - NP_001309918
RefSeq Peptide - NP_001309919
RefSeq Peptide - NP_001309920
RefSeq Peptide - NP_001309921
RefSeq Peptide - NP_001309922
RefSeq Peptide - NP_003938
RefSeq Peptide - NP_008995
RefSeq Peptide - NP_001019831
swissprot - C9IZQ6
swissprot - H7BXZ5
swissprot - H7C0I9
swissprot - H7C1X7
swissprot - J3QSW6
swissprot - C9J1B4
swissprot - O60229
swissprot - A0A0D9SGH1
Ensembl - ENSG00000160145
  
Related genetic diseases (OMIM): 608901 - {Coronary heart disease, susceptibility to, 5}, 608901
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 FP015810.1ENSDARG00000112749Danio rerio
 kalrnaENSDARG00000104119Danio rerio
 kalrnbENSDARG00000063538Danio rerio
 KALRNENSGALG00000011744Gallus gallus
 KalrnENSMUSG00000061751Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TRIO / O75962 / trio Rho guanine nucleotide exchange factorENSG0000003838277
MCF2L / O15068 / MCF.2 cell line derived transforming sequence likeENSG000001262179
MCF2L2 / Q86YR7 / MCF.2 cell line derived transforming sequence-like 2ENSG000000535249
MCF2 / P10911 / MCF.2 cell line derived transforming sequenceENSG000001019778
Q86VW2 / ARHGEF25 / Rho guanine nucleotide exchange factor 25ENSG000002407712
Q9ULL1 / PLEKHG1 / pleckstrin homology and RhoGEF domain containing G1ENSG000001202781
Q9H7P9 / PLEKHG2 / pleckstrin homology and RhoGEF domain containing G2ENSG000000909241
A1L390 / PLEKHG3 / pleckstrin homology and RhoGEF domain containing G3ENSG000001268221


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR000719  Protein kinase domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR002017  Spectrin repeat
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR003961  Fibronectin type III
 IPR007110  Immunoglobulin-like domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR013098  Immunoglobulin I-set
 IPR013783  Immunoglobulin-like fold
 IPR017441  Protein kinase, ATP binding site
 IPR018159  Spectrin/alpha-actinin
 IPR028569  Kalirin
 IPR035899  Dbl homology (DH) domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036116  Fibronectin type III superfamily
 IPR036865  CRAL-TRIO lipid binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001662 behavioral fear response IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0007399 nervous system development ISS
 biological_processGO:0007528 neuromuscular junction development IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0008344 adult locomotory behavior IEA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0014909 smooth muscle cell migration IEA
 biological_processGO:0016192 vesicle-mediated transport TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0035176 social behavior IEA
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0042711 maternal behavior IEA
 biological_processGO:0043065 positive regulation of apoptotic process TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046959 habituation IEA
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0048148 behavioral response to cocaine IEA
 biological_processGO:0048168 regulation of neuronal synaptic plasticity IEA
 biological_processGO:0048659 smooth muscle cell proliferation IEA
 biological_processGO:0051056 regulation of small GTPase mediated signal transduction TAS
 biological_processGO:0051966 regulation of synaptic transmission, glutamatergic IEA
 biological_processGO:0060125 negative regulation of growth hormone secretion IEA
 biological_processGO:0060137 maternal process involved in parturition IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 biological_processGO:0061003 positive regulation of dendritic spine morphogenesis IEA
 biological_processGO:0061368 behavioral response to formalin induced pain IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1900273 positive regulation of long-term synaptic potentiation IEA
 biological_processGO:1903076 regulation of protein localization to plasma membrane IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0015629 actin cytoskeleton TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
EPHB-mediated forward signaling
G alpha (q) signalling events
G alpha (12/13) signalling events
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088256 GNA11 / P29992 / G protein subunit alpha 11  / reaction / complex
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / reaction / complex
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / reaction / complex
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / reaction
 ENSG00000089022 Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5  / complex / reaction
 ENSG00000069956 MAPK6 / Q16659 / mitogen-activated protein kinase 6  / reaction / complex
 ENSG00000060558 GNA15 / P30679 / G protein subunit alpha 15  / reaction / complex
 ENSG00000156052 GNAQ / P50148 / G protein subunit alpha q  / reaction / complex
 ENSG00000156049 GNA14 / O95837 / G protein subunit alpha 14  / reaction / complex






 

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