ENSDARG00000104119


Danio rerio

Features
Gene ID: ENSDARG00000104119
  
Biological name :kalrna
  
Synonyms : kalirin RhoGEF kinase a / kalrna
  
Possible biological names infered from orthology : A2CG49 / Kalirin / kalirin RhoGEF kinase / KALRN / O60229
  
Species: Danio rerio
  
Chr. number: 9
Strand: 1
Band:
Gene start: 4250918
Gene end: 4419788
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000155392
Ensembl peptide - ENSDARP00000156196
Ensembl peptide - ENSDARP00000129946
Ensembl peptide - ENSDARP00000142005
Ensembl peptide - ENSDARP00000149309
Ensembl peptide - ENSDARP00000155290
swissprot - A0A0R4I9W4
swissprot - A0A0R4IYK1
ZFIN ID - ZDB-GENE-100921-4
Ensembl - ENSDARG00000104119
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KALRNENSGALG00000011744Gallus gallus
 KALRNENSG00000160145Homo sapiens
 KalrnENSMUSG00000061751Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
trioa / trio Rho guanine nucleotide exchange factor a / TRIO* / Q0KL02* / O75962* / Triple functional domain protein * / trio Rho guanine nucleotide exchange factor*ENSDARG0000001942667
triob / trio Rho guanine nucleotide exchange factor b / TRIO* / O75962* / trio Rho guanine nucleotide exchange factor*ENSDARG0000000037065
kalrnb / kalirin RhoGEF kinase b / KALRN* / O60229* / A2CG49* / Kalirin * / kalirin RhoGEF kinase*ENSDARG0000006353817
arhgef25b / Rho guanine nucleotide exchange factor (GEF) 25b / Q86VW2* / ARHGEF25* / Rho guanine nucleotide exchange factor 25* / Mus musculus Rho guanine nucleotide exchange factor (GEF) 2...ENSDARG0000001446511
mcf2lb / mcf.2 cell line derived transforming sequence-like b / MCF2L* / O15068* / MCF.2 cell line derived transforming sequence like*ENSDARG0000007648011
mcf2la / mcf.2 cell line derived transforming sequence-like a / MCF2L* / O15068* / MCF.2 cell line derived transforming sequence like*ENSDARG0000007585911
mcf2a / MCF.2 cell line derived transforming sequence a / MCF2* / P10911* / MCF.2 cell line derived transforming sequence*ENSDARG0000002289511
mcf2l2 / MCF.2 cell line derived transforming sequence-like 2 / Q86YR7*ENSDARG0000007974211
BX539336.1 / Q86VW2* / ARHGEF25* / Rho guanine nucleotide exchange factor 25*ENSDARG0000010060610
mcf2b / MCF.2 cell line derived transforming sequence b / MCF2* / P10911* / MCF.2 cell line derived transforming sequence*ENSDARG000000566039
plekhg2 / pleckstrin homology domain containing, family G (with RhoGef domain) member 2ENSDARG000000584594
si:ch73-212j7.3 / A1L390* / Q4VAC9* / PLEKHG3* / pleckstrin homology and RhoGEF domain containing G3* / Pleckstrin homology domain-containing family G member 3 *ENSDARG000000966132
CABZ01048666.1 / Q9ULL1* / PLEKHG1* / pleckstrin homology and RhoGEF domain containing G1*ENSDARG000001115852
FP015810.1 / KALRN* / O60229* / kalirin RhoGEF kinase*ENSDARG000001127490


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR002017  Spectrin repeat
 IPR011993  PH-like domain superfamily
 IPR018159  Spectrin/alpha-actinin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
EPHB-mediated forward signaling
G alpha (q) signalling events
G alpha (12/13) signalling events
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000094 blood island blood island has fewer parts of type hematopoietic stem cell , abnormal
blood island has fewer parts of type neutrophil , abnormal
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 ZFA:0009046 T cell T cell decreased amount , abnormal
Show

 ZFA:0009323 thrombocyte thrombocyte decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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