ENSDARG00000063538


Danio rerio

Features
Gene ID: ENSDARG00000063538
  
Biological name :kalrnb
  
Synonyms : kalirin RhoGEF kinase b / kalrnb
  
Possible biological names infered from orthology : A2CG49 / Kalirin / kalirin RhoGEF kinase / KALRN / O60229
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 9289802
Gene end: 9455966
  
Corresponding Affymetrix probe sets: Dr.17624.1.S1_at (Zebrafish Array)   Dr.17624.2.A1_at (Zebrafish Array)   NM_001040393_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000139401
Ensembl peptide - ENSDARP00000144861
Ensembl peptide - ENSDARP00000010346
Ensembl peptide - ENSDARP00000125636
Ensembl peptide - ENSDARP00000133649
NCBI entrez gene - 678652     See in Manteia.
RefSeq - NM_001327990
RefSeq - NM_001040393
RefSeq - NM_001327989
RefSeq Peptide - NP_001035483
RefSeq Peptide - NP_001314919
RefSeq Peptide - NP_001314918
swissprot - I3IRX7
swissprot - A0A0R4IJ99
swissprot - A0A0R4IVJ3
swissprot - Q1RLV0
ZFIN ID - ZDB-GENE-060421-7244
Ensembl - ENSDARG00000063538
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KALRNENSGALG00000011744Gallus gallus
 KALRNENSG00000160145Homo sapiens
 KalrnENSMUSG00000061751Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
kalrna / kalirin RhoGEF kinase a / KALRN* / O60229* / A2CG49* / Kalirin * / kalirin RhoGEF kinase*ENSDARG0000010411968
triob / trio Rho guanine nucleotide exchange factor b / TRIO* / O75962* / trio Rho guanine nucleotide exchange factor*ENSDARG0000000037053
trioa / trio Rho guanine nucleotide exchange factor a / TRIO* / Q0KL02* / O75962* / Triple functional domain protein * / trio Rho guanine nucleotide exchange factor*ENSDARG0000001942652
BX539336.1 / Q86VW2* / ARHGEF25* / Rho guanine nucleotide exchange factor 25*ENSDARG0000010060638
arhgef25b / Rho guanine nucleotide exchange factor (GEF) 25b / Q86VW2* / ARHGEF25* / Rho guanine nucleotide exchange factor 25* / Mus musculus Rho guanine nucleotide exchange factor (GEF) 2...ENSDARG0000001446536
mcf2la / mcf.2 cell line derived transforming sequence-like a / MCF2L* / O15068* / MCF.2 cell line derived transforming sequence like*ENSDARG0000007585922
mcf2a / MCF.2 cell line derived transforming sequence a / MCF2* / P10911* / MCF.2 cell line derived transforming sequence*ENSDARG0000002289521
mcf2l2 / MCF.2 cell line derived transforming sequence-like 2 / Q86YR7*ENSDARG0000007974220
mcf2lb / mcf.2 cell line derived transforming sequence-like b / MCF2L* / O15068* / MCF.2 cell line derived transforming sequence like*ENSDARG0000007648019
mcf2b / MCF.2 cell line derived transforming sequence b / MCF2* / P10911* / MCF.2 cell line derived transforming sequence*ENSDARG0000005660317
plekhg2 / pleckstrin homology domain containing, family G (with RhoGef domain) member 2ENSDARG0000005845916
CABZ01048666.1 / Q9ULL1* / PLEKHG1* / pleckstrin homology and RhoGEF domain containing G1*ENSDARG000001115858
si:ch73-212j7.3 / A1L390* / Q4VAC9* / PLEKHG3* / pleckstrin homology and RhoGEF domain containing G3* / Pleckstrin homology domain-containing family G member 3 *ENSDARG000000966136
FP015810.1 / KALRN* / O60229* / kalirin RhoGEF kinase*ENSDARG000001127490


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001251  CRAL-TRIO lipid binding domain
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR002017  Spectrin repeat
 IPR011993  PH-like domain superfamily
 IPR018159  Spectrin/alpha-actinin
 IPR028569  Kalirin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
NRAGE signals death through JNK
Rho GTPase cycle
EPHB-mediated forward signaling
G alpha (q) signalling events
G alpha (12/13) signalling events
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000094 blood island blood island has fewer parts of type hematopoietic stem cell , abnormal
blood island has fewer parts of type neutrophil , abnormal
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 ZFA:0005028 ventral wall of dorsal aorta ventral wall of dorsal aorta has fewer parts of type hematopoietic stem cell , abnormal
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 ZFA:0009046 T cell T cell decreased amount , abnormal
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 ZFA:0009323 thrombocyte thrombocyte decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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