ENSG00000069956


Homo sapiens

Features
Gene ID: ENSG00000069956
  
Biological name :MAPK6
  
Synonyms : MAPK6 / mitogen-activated protein kinase 6 / Q16659
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q21.2
Gene start: 51952106
Gene end: 52067372
  
Corresponding Affymetrix probe sets: 207121_s_at (Human Genome U133 Plus 2.0 Array)   243831_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000261845
NCBI entrez gene - 5597     See in Manteia.
OMIM - 602904
RefSeq - XM_011521782
RefSeq - NM_002748
RefSeq - XM_005254538
RefSeq - XM_005254539
RefSeq - XM_005254537
RefSeq Peptide - NP_002739
swissprot - Q16659
Ensembl - ENSG00000069956
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mapk6ENSDARG00000032103Danio rerio
 MAPK6ENSGALG00000031448Gallus gallus
 Mapk6ENSMUSG00000042688Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAPK4 / P31152 / mitogen-activated protein kinase 4ENSG0000014163945
MAPK7 / Q13164 / mitogen-activated protein kinase 7ENSG0000016648425
MAPK15 / Q8TD08 / mitogen-activated protein kinase 15ENSG0000018108521
MAPK3 / P27361 / mitogen-activated protein kinase 3ENSG0000010288221
MAPK1 / P28482 / mitogen-activated protein kinase 1ENSG0000010003021
NLK / Q9UBE8 / nemo like kinaseENSG0000008709517


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR008350  Mitogen-activated protein (MAP) kinase, ERK3/4
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0010468 regulation of gene expression IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0060999 positive regulation of dendritic spine development IEA
 biological_processGO:0071310 cellular response to organic substance IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0032156 septin cytoskeleton IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004707 MAP kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000089022 Q8IW41 / MAPKAPK5 / mitogen-activated protein kinase-activated protein kinase 5  / reaction / complex
 ENSG00000149798 O14613 / CDC42EP2 / CDC42 effector protein 2  / reaction
 ENSG00000112576 CCND3 / P30281 / cyclin D3  / reaction / complex
 ENSG00000124151 NCOA3 / Q9Y6Q9 / nuclear receptor coactivator 3  / reaction
 ENSG00000081377 CDC14B / O60729 / cell division cycle 14B  / complex / reaction
 ENSG00000122545 SEPT7 / Q16181 / septin 7  / reaction / complex
 ENSG00000079335 CDC14A / Q9UNH5 / cell division cycle 14A  / complex / reaction
 ENSG00000160145 KALRN / O60229 / kalirin RhoGEF kinase  / complex / reaction
 ENSG00000163171 Q9UKI2 / CDC42EP3 / CDC42 effector protein 3  / reaction
 ENSG00000167617 Q6NZY7 / CDC42EP5 / CDC42 effector protein 5  / reaction
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / reaction
 ENSG00000170312 CDK1 / P06493 / cyclin dependent kinase 1  / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / reaction






 

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