ENSG00000149269


Homo sapiens

Features
Gene ID: ENSG00000149269
  
Biological name :PAK1
  
Synonyms : p21 (RAC1) activated kinase 1 / PAK1 / Q13153
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: q14.1
Gene start: 77321707
Gene end: 77474635
  
Corresponding Affymetrix probe sets: 1565772_at (Human Genome U133 Plus 2.0 Array)   209615_s_at (Human Genome U133 Plus 2.0 Array)   226507_at (Human Genome U133 Plus 2.0 Array)   230100_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431541
Ensembl peptide - ENSP00000437261
Ensembl peptide - ENSP00000435983
Ensembl peptide - ENSP00000433737
Ensembl peptide - ENSP00000433518
Ensembl peptide - ENSP00000433423
Ensembl peptide - ENSP00000433211
Ensembl peptide - ENSP00000433004
Ensembl peptide - ENSP00000432477
Ensembl peptide - ENSP00000431906
Ensembl peptide - ENSP00000278568
Ensembl peptide - ENSP00000348696
NCBI entrez gene - 5058     See in Manteia.
OMIM - 602590
RefSeq - XM_017017850
RefSeq - NM_001128620
RefSeq - NM_002576
RefSeq - XM_011545080
RefSeq - XM_011545081
RefSeq - XM_011545082
RefSeq - XM_011545083
RefSeq - XM_011545084
RefSeq - XM_017017846
RefSeq - XM_017017847
RefSeq - XM_017017848
RefSeq - XM_017017849
RefSeq Peptide - NP_002567
RefSeq Peptide - NP_001122092
swissprot - E9PM17
swissprot - E9PKH9
swissprot - E9PJF8
swissprot - B3KNX7
swissprot - A0A024R5P0
swissprot - E9PQW5
swissprot - H0YCG5
swissprot - H0YCM0
swissprot - H0YF55
swissprot - E9PRP6
swissprot - Q13153
swissprot - E9PMP2
Ensembl - ENSG00000149269
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PAK1ENSGALG00000000681Gallus gallus
 Pak1ENSMUSG00000030774Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PAK3 / O75914 / p21 (RAC1) activated kinase 3ENSG0000007726477
PAK2 / Q13177 / p21 (RAC1) activated kinase 2ENSG0000018037071
PAK5 / Q9P286 / p21 (RAC1) activated kinase 5ENSG0000010134936
PAK4 / O96013 / p21 (RAC1) activated kinase 4ENSG0000013066935
PAK6 / Q9NQU5 / p21 (RAC1) activated kinase 6ENSG0000013784334
BUB1B-PAK6 / BUB1B-PAK6 readthroughENSG0000025928834
TAOK1 / Q7L7X3 / TAO kinase 1ENSG0000016055123
TAOK2 / Q9UL54 / TAO kinase 2ENSG0000014993022
TAOK3 / Q9H2K8 / TAO kinase 3ENSG0000013509021


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033923  p21 activated kinase binding domain
 IPR036936  CRIB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007266 Rho protein signal transduction IBA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010033 response to organic substance IEA
 biological_processGO:0010763 positive regulation of fibroblast migration IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0021549 cerebellum development IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0030335 positive regulation of cell migration IDA
 biological_processGO:0031116 positive regulation of microtubule polymerization IMP
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033148 positive regulation of intracellular estrogen receptor signaling pathway IDA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043507 positive regulation of JUN kinase activity IMP
 biological_processGO:0045773 positive regulation of axon extension IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0048012 hepatocyte growth factor receptor signaling pathway IMP
 biological_processGO:0048013 ephrin receptor signaling pathway TAS
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0048812 neuron projection morphogenesis IEA
 biological_processGO:0050770 regulation of axonogenesis IBA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051496 positive regulation of stress fiber assembly IMP
 biological_processGO:0060244 negative regulation of cell proliferation involved in contact inhibition IMP
 biological_processGO:0061052 negative regulation of cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0090314 positive regulation of protein targeting to membrane IEA
 biological_processGO:1904707 positive regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1904754 positive regulation of vascular associated smooth muscle cell migration IEA
 biological_processGO:2001275 positive regulation of glucose import in response to insulin stimulus IEA
 cellular_componentGO:0001726 ruffle IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005925 focal adhesion IEA
 cellular_componentGO:0014704 intercalated disc IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031941 filamentous actin NAS
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0071437 invadopodium IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005518 collagen binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IPI


Pathways (from Reactome)
Pathway description
Generation of second messenger molecules
Regulation of actin dynamics for phagocytic cup formation
FCERI mediated MAPK activation
DSCAM interactions
CD28 dependent Vav1 pathway
EPHB-mediated forward signaling
Ephrin signaling
Sema3A PAK dependent Axon repulsion
Activation of RAC1
Signal transduction by L1
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PKNs
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000043462 LCP2 / Q13094 / lymphocyte cytosolic protein 2  / complex / reaction
 ENSG00000090776 EFNB1 / P98172 / ephrin B1  / complex / reaction
 ENSG00000010810 FYN / P06241 / FYN proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000108262 GIT1 / Q9Y2X7 / GIT ArfGAP 1  / complex / reaction
 ENSG00000108947 EFNB3 / Q15768 / ephrin B3  / complex / reaction
 ENSG00000102606 Q14155 / ARHGEF7 / Rho guanine nucleotide exchange factor 7  / complex / reaction
 ENSG00000125266 EFNB2 / P52799 / ephrin B2  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / complex / reaction
 ENSG00000071051 NCK2 / O43639 / NCK adaptor protein 2  / complex / reaction
 ENSG00000077264 PAK3 / O75914 / p21 (RAC1) activated kinase 3  / reaction
 ENSG00000075213 Q14563 / SEMA3A / semaphorin 3A  / complex / reaction
 ENSG00000099250 NRP1 / O14786 / neuropilin 1  / complex / reaction
 ENSG00000158092 NCK1 / P16333 / NCK adaptor protein 1  / reaction / complex
 ENSG00000141968 VAV1 / P15498 / vav guanine nucleotide exchange factor 1  / complex / reaction
 ENSG00000114554 PLXNA1 / Q9UIW2 / plexin A1  / reaction / complex
 ENSG00000134215 VAV3 / Q9UKW4 / vav guanine nucleotide exchange factor 3  / complex / reaction
 ENSG00000076356 O75051 / PLXNA2 / plexin A2  / reaction / complex
 ENSG00000070831 CDC42 / P60953 / cell division cycle 42  / complex / reaction
 ENSG00000198561 CTNND1 / O60716 / catenin delta 1  / reaction
 ENSG00000132155 RAF1 / P04049 / Raf-1 proto-oncogene, serine/threonine kinase  / reaction
 ENSG00000141639 MAPK4 / P31152 / mitogen-activated protein kinase 4  / reaction
 ENSG00000101608 MYL12A / P19105 / myosin light chain 12A  / reaction
 ENSG00000106683 LIMK1 / P53667 / LIM domain kinase 1  / reaction
 ENSG00000196924 FLNA / P21333 / filamin A  / reaction / complex
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000213639 P62140 / PPP1CB / protein phosphatase 1 catalytic subunit beta  / reaction
 ENSG00000197122 SRC / P12931 / SRC proto-oncogene, non-receptor tyrosine kinase  / complex / reaction
 ENSG00000077157 O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12B  / reaction
 ENSG00000069956 MAPK6 / Q16659 / mitogen-activated protein kinase 6  / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / reaction
 ENSG00000174775 HRAS / P01112 / HRas proto-oncogene, GTPase  / reaction
 ENSG00000179776 CDH5 / P33151 / cadherin 5  / reaction
 ENSG00000221866 PLXNA4 / Q9HCM2 / plexin A4  / reaction / complex
 ENSG00000133703 KRAS / P01116 / KRAS proto-oncogene, GTPase  / reaction
 ENSG00000044115 CTNNA1 / P35221 / catenin alpha 1  / reaction
 ENSG00000107643 MAPK8 / P45983 / mitogen-activated protein kinase 8  / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / complex / reaction
 ENSG00000182511 FES / P07332 / FES proto-oncogene, tyrosine kinase  / reaction / complex
 ENSG00000130827 P51805 / PLXNA3 / plexin A3  / reaction / complex
 ENSG00000173801 JUP / P14923 / junction plakoglobin  / reaction
 ENSG00000160293 VAV2 / P52735 / vav guanine nucleotide exchange factor 2  / reaction / complex
 ENSG00000213281 NRAS / P01111 / NRAS proto-oncogene, GTPase  / reaction
 ENSG00000058272 O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12A  / reaction
 ENSG00000085733 CTTN / Q14247 / cortactin  / reaction
 ENSG00000177885 GRB2 / P62993 / growth factor receptor bound protein 2  / complex / reaction
 ENSG00000100351 GRAP2 / O75791 / GRB2-related adaptor protein 2  / complex / reaction
 ENSG00000186575 NF2 / P35240 / neurofibromin 2  / complex / reaction
 ENSG00000213658 LAT / O43561 / linker for activation of T cells  / reaction / complex
 ENSG00000197943 PLCG2 / P16885 / phospholipase C gamma 2  / complex / reaction
 ENSG00000160691 SHC1 / P29353 / SHC adaptor protein 1  / reaction / complex
 ENSG00000171587 DSCAM / O60469 / DS cell adhesion molecule  / complex / reaction
 ENSG00000115904 SOS1 / Q07889 / SOS Ras/Rac guanine nucleotide exchange factor 1  / complex / reaction






 

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