ENSG00000137843


Homo sapiens

Features
Gene ID: ENSG00000137843
  
Biological name :PAK6
  
Synonyms : p21 (RAC1) activated kinase 6 / PAK6 / Q9NQU5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q15.1
Gene start: 40238759
Gene end: 40277487
  
Corresponding Affymetrix probe sets: 1555310_a_at (Human Genome U133 Plus 2.0 Array)   219461_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452686
Ensembl peptide - ENSP00000452737
Ensembl peptide - ENSP00000453005
Ensembl peptide - ENSP00000453021
Ensembl peptide - ENSP00000453057
Ensembl peptide - ENSP00000453407
Ensembl peptide - ENSP00000453520
Ensembl peptide - ENSP00000453721
Ensembl peptide - ENSP00000453858
Ensembl peptide - ENSP00000260404
Ensembl peptide - ENSP00000409465
Ensembl peptide - ENSP00000439597
Ensembl peptide - ENSP00000452647
Ensembl peptide - ENSP00000452708
NCBI entrez gene - 56924     See in Manteia.
NCBI entrez gene - 106821730     See in Manteia.
OMIM - 608110
RefSeq - NM_020168
RefSeq - NM_001128629
RefSeq - NM_001276717
RefSeq - NM_001276718
RefSeq Peptide - NP_064553
RefSeq Peptide - NP_001263647
RefSeq Peptide - NP_001263646
RefSeq Peptide - NP_001122101
swissprot - Q9NQU5
swissprot - A0A024R9Q4
swissprot - H0YK38
swissprot - H0YK74
swissprot - H0YK91
swissprot - H0YKB6
swissprot - H0YL02
swissprot - H0YL16
swissprot - H0YL47
swissprot - H0YLZ9
swissprot - H0YM99
swissprot - H0YMS4
Ensembl - ENSG00000137843
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pak6aENSDARG00000027564Danio rerio
 pak6bENSDARG00000052405Danio rerio
 ENSGALG00000034605Gallus gallus
 Pak6ENSMUSG00000074923Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
BUB1B-PAK6 / BUB1B-PAK6 readthroughENSG00000259288100
PAK5 / Q9P286 / p21 (RAC1) activated kinase 5ENSG0000010134949
PAK4 / O96013 / p21 (RAC1) activated kinase 4ENSG0000013066947
PAK1 / Q13153 / p21 (RAC1) activated kinase 1ENSG0000014926928
PAK3 / O75914 / p21 (RAC1) activated kinase 3ENSG0000007726428
PAK2 / Q13177 / p21 (RAC1) activated kinase 2ENSG0000018037028
TAOK1 / Q7L7X3 / TAO kinase 1ENSG0000016055117
TAOK3 / Q9H2K8 / TAO kinase 3ENSG0000013509017
TAOK2 / Q9UL54 / TAO kinase 2ENSG0000014993017


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033923  p21 activated kinase binding domain
 IPR035066  Serine/threonine-protein kinase PAK 6
 IPR036936  CRIB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007010 cytoskeleton organization TAS
 biological_processGO:0007266 Rho protein signal transduction IBA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030036 actin cytoskeleton organization IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 cellular_componentGO:0001650 fibrillar center IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0030054 cell junction IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0045296 cadherin binding IDA
 molecular_functionGO:0048365 Rac GTPase binding IBA


Pathways (from Reactome)
Pathway description
Activation of RAC1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr