ENSG00000160551


Homo sapiens

Features
Gene ID: ENSG00000160551
  
Biological name :TAOK1
  
Synonyms : Q7L7X3 / TAOK1 / TAO kinase 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q11.2
Gene start: 29390464
Gene end: 29551904
  
Corresponding Affymetrix probe sets: 216310_at (Human Genome U133 Plus 2.0 Array)   224769_at (Human Genome U133 Plus 2.0 Array)   224778_s_at (Human Genome U133 Plus 2.0 Array)   227454_at (Human Genome U133 Plus 2.0 Array)   231193_s_at (Human Genome U133 Plus 2.0 Array)   238420_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464562
Ensembl peptide - ENSP00000261716
Ensembl peptide - ENSP00000438819
NCBI entrez gene - 57551     See in Manteia.
OMIM - 610266
RefSeq - XM_011525060
RefSeq - NM_020791
RefSeq - NM_025142
RefSeq Peptide - NP_065842
RefSeq Peptide - NP_079418
swissprot - A0A024QZ70
swissprot - J3QS76
swissprot - Q7L7X3
Ensembl - ENSG00000160551
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 taok1aENSDARG00000069603Danio rerio
 taok1bENSDARG00000098304Danio rerio
 TAOK1ENSGALG00000004082Gallus gallus
 Taok1ENSMUSG00000017291Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TAOK3 / Q9H2K8 / TAO kinase 3ENSG0000013509066
TAOK2 / Q9UL54 / TAO kinase 2ENSG0000014993060
PAK3 / O75914 / p21 (RAC1) activated kinase 3ENSG0000007726413
PAK2 / Q13177 / p21 (RAC1) activated kinase 2ENSG0000018037012
PAK4 / O96013 / p21 (RAC1) activated kinase 4ENSG0000013066912
PAK1 / Q13153 / p21 (RAC1) activated kinase 1ENSG0000014926912
PAK5 / Q9P286 / p21 (RAC1) activated kinase 5ENSG0000010134911
BUB1B-PAK6 / BUB1B-PAK6 readthroughENSG0000025928811
PAK6 / Q9NQU5 / p21 (RAC1) activated kinase 6ENSG0000013784311


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006468 protein phosphorylation NAS
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007062 sister chromatid cohesion TAS
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IMP
 biological_processGO:0007257 activation of JUN kinase activity TAS
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IMP
 biological_processGO:0032956 regulation of actin cytoskeleton organization ISS
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0046330 positive regulation of JNK cascade IDA
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0051493 regulation of cytoskeleton organization ISS
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization ISS
 biological_processGO:0097194 execution phase of apoptosis IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity ISS
 molecular_functionGO:0004674 protein serine/threonine kinase activity NAS
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding NAS
 molecular_functionGO:0016301 kinase activity NAS
 molecular_functionGO:0016740 transferase activity NAS
 molecular_functionGO:0043539 protein serine/threonine kinase activator activity ISS


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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