ENSG00000101349


Homo sapiens

Features
Gene ID: ENSG00000101349
  
Biological name :PAK5
  
Synonyms : p21 (RAC1) activated kinase 5 / PAK5 / Q9P286
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: p12.2
Gene start: 9537389
Gene end: 9839041
  
Corresponding Affymetrix probe sets: 210721_s_at (Human Genome U133 Plus 2.0 Array)   213990_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000322957
Ensembl peptide - ENSP00000367679
Ensembl peptide - ENSP00000367686
NCBI entrez gene - 57144     See in Manteia.
OMIM - 608038
RefSeq - XM_017027965
RefSeq - NM_020341
RefSeq - NM_177990
RefSeq - XM_017027962
RefSeq - XM_017027963
RefSeq - XM_017027964
RefSeq - XM_017027960
RefSeq - XM_017027961
RefSeq Peptide - NP_817127
RefSeq Peptide - NP_065074
swissprot - Q9P286
Ensembl - ENSG00000101349
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pak7ENSDARG00000030154Danio rerio
 PAK5ENSGALG00000008947Gallus gallus
 Pak7ENSMUSG00000039913Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PAK4 / O96013 / p21 (RAC1) activated kinase 4ENSG0000013066952
BUB1B-PAK6 / BUB1B-PAK6 readthroughENSG0000025928846
PAK6 / Q9NQU5 / p21 (RAC1) activated kinase 6ENSG0000013784346
PAK3 / O75914 / p21 (RAC1) activated kinase 3ENSG0000007726428
PAK1 / Q13153 / p21 (RAC1) activated kinase 1ENSG0000014926928
PAK2 / Q13177 / p21 (RAC1) activated kinase 2ENSG0000018037027
TAOK1 / Q7L7X3 / TAO kinase 1ENSG0000016055116
TAOK3 / Q9H2K8 / TAO kinase 3ENSG0000013509016
TAOK2 / Q9UL54 / TAO kinase 2ENSG0000014993015


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028754  Serine/threonine-protein kinase PAK5
 IPR033923  p21 activated kinase binding domain
 IPR036936  CRIB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0007010 cytoskeleton organization TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007266 Rho protein signal transduction IBA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007612 learning IEA
 biological_processGO:0007613 memory IEA
 biological_processGO:0007626 locomotory behavior IEA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0016049 cell growth TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration TAS
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030036 actin cytoskeleton organization IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005739 mitochondrion IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0048365 Rac GTPase binding IBA


Pathways (from Reactome)
Pathway description
Activation of RAC1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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