ENSMUSG00000074923


Mus musculus

Features
Gene ID: ENSMUSG00000074923
  
Biological name :Pak6
  
Synonyms : Pak6 / Q3ULB5 / Serine/threonine-protein kinase PAK 6
  
Possible biological names infered from orthology : BUB1B-PAK6 / BUB1B-PAK6 readthrough / p21 (RAC1) activated kinase 6 / Q9NQU5
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 118663303
Gene end: 118698020
  
Corresponding Affymetrix probe sets: 10474793 (MoGene1.0st)   1445475_at (Mouse Genome 430 2.0 Array)   1455200_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000097153
Ensembl peptide - ENSMUSP00000106477
NCBI entrez gene - 214230     See in Manteia.
MGI - MGI:2679420
RefSeq - XM_011239420
RefSeq - NM_001033254
RefSeq - NM_001145854
RefSeq - XM_011239419
RefSeq Peptide - NP_001028426
RefSeq Peptide - NP_001139326
swissprot - Q3ULB5
Ensembl - ENSMUSG00000074923
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pak6aENSDARG00000027564Danio rerio
 pak6bENSDARG00000052405Danio rerio
 ENSGALG00000034605Gallus gallus
 BUB1B-PAK6ENSG00000259288Homo sapiens
 PAK6ENSG00000137843Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pak7 / Q8C015 / Serine/threonine-protein kinase PAK 5 / PAK5* / Q9P286* / p21 (RAC1) activated kinase 5*ENSMUSG0000003991348
Pak4 / Q8BTW9 / Serine/threonine-protein kinase PAK 4 / O96013* / p21 (RAC1) activated kinase 4*ENSMUSG0000003060246
Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*ENSMUSG0000003077428
Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*ENSMUSG0000003128428
Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*ENSMUSG0000002278127
Taok1 / Q5F2E8 / TAO kinase 1 / Q7L7X3*ENSMUSG0000001729117
Taok3 / Q8BYC6 / TAO kinase 3 / Q9H2K8*ENSMUSG0000006128817
Taok2 / Q6ZQ29 / Serine/threonine-protein kinase TAO2 / Q9UL54* / TAO kinase 2*ENSMUSG0000005998116


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033923  p21 activated kinase binding domain
 IPR035066  Serine/threonine-protein kinase PAK 6
 IPR036936  CRIB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IBA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007266 Rho protein signal transduction IBA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007612 learning IGI
 biological_processGO:0007613 memory IGI
 biological_processGO:0007626 locomotory behavior IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030036 actin cytoskeleton organization IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0030054 cell junction ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0048365 Rac GTPase binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Aiy/Aiy
Genetic Background: C3H/HeJ-Aiy

 MP:0001417 decreased exploration in new environment "less amount of time spent investigating a new location" [J:79870]
Show

Allelic Composition: Aiy/Aiy
Genetic Background: C3H/HeJ-Aiy

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Aiy/Aiy
Genetic Background: C3H/HeJ-Aiy

 MP:0002798 abnormal active avoidance behavior "defects in the ability to escape a hostile environment to actively avoid the unpleasant or punishing stimuli ( e.g. shock) previously encountered in this environment" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Aiy/Aiy
Genetic Background: C3H/HeJ-Aiy

 MP:0002882 abnormal neuron "anomaly in the functional cells of the nervous system that receive, conduct, and transmit impulses " [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Aiy/Aiy
Genetic Background: C3H/HeJ-Aiy

 MP:0003862 decreased aggression towards males "when compared to controls, subjects exhibit less than normal level of domineering, assaultive posture and/or hostile physical action towards male mice " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aiy/Aiy
Genetic Background: C3H/HeJ-Aiy

 MP:0004000 impaired passive avoidance behavior "decrease in or absence of the latency of an animal to enter an hostile environment where it receives a unpleasant or punishing stimuli applied previously" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aiy/Aiy
Genetic Background: C3H/HeJ-Aiy

 MP:0008415 abnormal neurite morphology "any structural anomaly of a neuronal process, either a dendrite or an axon in vivo, or a filamentous projection from a neuron such as is seen in tissue culture" [PMID:12951572]
Show

Allelic Composition: Aiy/Aiy
Genetic Background: C3H/HeJ-Aiy

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Aiy/Aiy
Genetic Background: C3H/HeJ-Aiy

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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