ENSMUSG00000059981


Mus musculus

Features
Gene ID: ENSMUSG00000059981
  
Biological name :Taok2
  
Synonyms : Q6ZQ29 / Serine/threonine-protein kinase TAO2 / Taok2
  
Possible biological names infered from orthology : Q9UL54 / TAO kinase 2
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: F3
Gene start: 126865678
Gene end: 126884703
  
Corresponding Affymetrix probe sets: 10568078 (MoGene1.0st)   1438208_at (Mouse Genome 430 2.0 Array)   1443642_at (Mouse Genome 430 2.0 Array)   1456826_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000150069
Ensembl peptide - ENSMUSP00000071246
Ensembl peptide - ENSMUSP00000112963
NCBI entrez gene - 381921     See in Manteia.
MGI - MGI:1915919
RefSeq - NM_001163774
RefSeq - NM_001163775
RefSeq Peptide - NP_001157246
RefSeq Peptide - NP_001157247
swissprot - A0A1L1SSV8
swissprot - Q6ZQ29
Ensembl - ENSMUSG00000059981
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 taok2aENSDARG00000074899Danio rerio
 taok2bENSDARG00000100620Danio rerio
 TAOK2ENSG00000149930Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Taok1 / Q5F2E8 / TAO kinase 1 / Q7L7X3*ENSMUSG0000001729148
Taok3 / Q8BYC6 / TAO kinase 3 / Q9H2K8*ENSMUSG0000006128841
Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*ENSMUSG0000003128410
Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*ENSMUSG0000002278110
Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*ENSMUSG0000003077410
Pak6 / Q3ULB5 / Serine/threonine-protein kinase PAK 6 / Q9NQU5* / BUB1B-PAK6* / BUB1B-PAK6 readthrough* / p21 (RAC1) activated kinase 6*ENSMUSG000000749239
Pak7 / Q8C015 / Serine/threonine-protein kinase PAK 5 / PAK5* / Q9P286* / p21 (RAC1) activated kinase 5*ENSMUSG000000399139
Pak4 / Q8BTW9 / Serine/threonine-protein kinase PAK 4 / O96013* / p21 (RAC1) activated kinase 4*ENSMUSG000000306029


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0008360 regulation of cell shape IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030036 actin cytoskeleton organization IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IEA
 biological_processGO:0032956 regulation of actin cytoskeleton organization IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0048041 focal adhesion assembly IEA
 biological_processGO:0051403 stress-activated MAPK cascade IEA
 biological_processGO:0150019 basal dendrite morphogenesis IMP
 biological_processGO:0150020 basal dendrite arborization IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0044294 dendritic growth cone IDA
 cellular_componentGO:0044295 axonal growth cone IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISO
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0031434 mitogen-activated protein kinase kinase binding IEA
 molecular_functionGO:0038191 neuropilin binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Hsp90aa1Tg(Tyr)2396BOve/Hsp90aa1Tg(Tyr)2396BOve
Genetic Background: FVB/N-Hsp90aa1Tg(Tyr)2396BOve

 MP:0003545 increased alcohol consumption "greater than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

Allelic Composition: Taok2tm1.2Dkap/Taok2tm1.2Dkap
Genetic Background: B6(Cg)-Taok2tm1.2Dkap

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Taok2tm1.2Dkap/Taok2tm1.2Dkap
Genetic Background: B6(Cg)-Taok2tm1.2Dkap

 MP:0009712 impaired conditioned place preference behavior "decrease in the ability of an animal to learn and remember an association between a putative rewarding internal state produced by a xenobiotic or drug with a neutral, unchanging environment" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Taok2tm1.2Dkap/Taok2tm1.2Dkap
Genetic Background: B6(Cg)-Taok2tm1.2Dkap

 MP:0009751 enhanced behavioral response to alcohol "increased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or decreased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clp1tm1.1Pngr/Clp1tm1.1Pngr
Genetic Background: B6.Cg-Clp1tm1.1Pngr

 MP:0009755 impaired behavioral response to alcohol "decreased sensitivity to alcohol resulting in a behavioral response, such as induced hyperactivity or stereotypic behavior, or increased dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Taok2tm1.2Dkap/Taok2tm1.2Dkap
Genetic Background: B6(Cg)-Taok2tm1.2Dkap

 MP:0011617 abnormal habituation "anomaly in the process in which there is a progressive decline of behavioral response probability with a repetitive stimulus" [GO:0046959, PMID:16774787]
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Allelic Composition: Taok2tm1.2Dkap/Taok2tm1.2Dkap
Genetic Background: B6(Cg)-Taok2tm1.2Dkap

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Taok2tm1.2Dkap/Taok2tm1.2Dkap
Genetic Background: B6(Cg)-Taok2tm1.2Dkap

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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