ENSMUSG00000030602


Mus musculus

Features
Gene ID: ENSMUSG00000030602
  
Biological name :Pak4
  
Synonyms : Pak4 / Q8BTW9 / Serine/threonine-protein kinase PAK 4
  
Possible biological names infered from orthology : O96013 / p21 (RAC1) activated kinase 4
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B1
Gene start: 28558819
Gene end: 28598185
  
Corresponding Affymetrix probe sets: 10561485 (MoGene1.0st)   1428548_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032823
Ensembl peptide - ENSMUSP00000103918
NCBI entrez gene - 70584     See in Manteia.
MGI - MGI:1917834
RefSeq - XM_017312297
RefSeq - NM_027470
RefSeq - XM_017312296
RefSeq Peptide - NP_081746
swissprot - Q8BTW9
Ensembl - ENSMUSG00000030602
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pak4ENSDARG00000018110Danio rerio
 PAK4ENSGALG00000031328Gallus gallus
 PAK4ENSG00000130669Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pak7 / Q8C015 / Serine/threonine-protein kinase PAK 5 / PAK5* / Q9P286* / p21 (RAC1) activated kinase 5*ENSMUSG0000003991362
Pak6 / Q3ULB5 / Serine/threonine-protein kinase PAK 6 / Q9NQU5* / BUB1B-PAK6* / BUB1B-PAK6 readthrough* / p21 (RAC1) activated kinase 6*ENSMUSG0000007492353
Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*ENSMUSG0000003077433
Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*ENSMUSG0000003128433
Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*ENSMUSG0000002278132
Taok1 / Q5F2E8 / TAO kinase 1 / Q7L7X3*ENSMUSG0000001729120
Taok3 / Q8BYC6 / TAO kinase 3 / Q9H2K8*ENSMUSG0000006128820
Taok2 / Q6ZQ29 / Serine/threonine-protein kinase TAO2 / Q9UL54* / TAO kinase 2*ENSMUSG0000005998119


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033923  p21 activated kinase binding domain
 IPR036936  CRIB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007266 Rho protein signal transduction IBA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030036 actin cytoskeleton organization IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0045766 positive regulation of angiogenesis ISO
 biological_processGO:0060996 dendritic spine development IGI
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005913 cell-cell adherens junction ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0048365 Rac GTPase binding IBA
 molecular_functionGO:0098641 cadherin binding involved in cell-cell adhesion ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fyntm1Rmp/Fyntm1Rmp,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas

 MP:0000937 abnormal motor neuron morphology "malformation or absence of cells that innervate an effector (muscle or glandular) tissue; responsible for transmission of motor impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

Allelic Composition: Pak4tm1Amin/Pak4tm1Amin
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
Show

Allelic Composition: Fyntm1Rmp/Fyntm1Rmp,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pak4tm2.1Amin/Pak4tm2.2Amin
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Pak4tm2.1Amin/Pak4tm2.2Amin,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Fyntm1Rmp/Fyntm1Rmp,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas

Allelic Composition: Meox2tm1(cre)Sor/Meox2+,Pak4tm2.1Amin/Pak4tm2.2Amin
Genetic Background: involves: 129S2/SvPas * 129S4/SvJaeSor * C57BL/6 * FVB/N

Allelic Composition: Pak4tm2.1Amin/Pak4tm2.2Amin,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
Show

Allelic Composition: Fyntm1Rmp/Fyntm1Rmp,Lcktm1Mak/Lcktm1Mak
Genetic Background: involves: 129S2/SvPas

 MP:0002151 abnormal neural tube morphology/development "anomalous structure of or development of the embryonic neural tube resulting in structural anomaly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
Show

Allelic Composition: Pak4tm1Amin/Pak4tm1Amin
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pak4tm1Amin/Pak4tm1Amin
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0003861 abnormal nervous system development "impaired or altered growth of the components of the nervous system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pak4tm1Amin/Pak4tm1Amin
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J)

Allelic Composition: Pak4tm2.1Amin/Pak4tm2.2Amin,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N

 MP:0004076 abnormal vitelline vascular remodelling "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pak4tm1Amin/Pak4tm1Amin
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0004100 abnormal spinal cord interneuron morphology "malformation or absence of neurons that exclusively interact with other neurons in the spinal cord" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0004266 pale placenta "placenta lacking normal reddish coloration, often refers to bloodless condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pak4tm1Amin/Pak4tm1Amin
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pak4tm1Amin/Pak4tm1Amin
Genetic Background: either: (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129S2/SvPas * C57BL/6J)

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Pak4tm2.1Amin/Pak4tm2.2Amin,Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * FVB/N

 MP:0012703 decreased embryonic neuroepithelium thickness "reduced width of the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [MGI:anna]
Show

Allelic Composition: Cplx1tm1Rmnd/Cplx1tm1Rmnd,Cplx2tm1Rmnd/Cplx2tm1Rmnd
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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