ENSDARG00000018110


Danio rerio

Features
Gene ID: ENSDARG00000018110
  
Biological name :pak4
  
Synonyms : p21 protein (Cdc42/Rac)-activated kinase 4 / pak4
  
Possible biological names infered from orthology : O96013 / p21 (RAC1) activated kinase 4 / Q8BTW9 / Serine/threonine-protein kinase PAK 4
  
Species: Danio rerio
  
Chr. number: 15
Strand: 1
Band:
Gene start: 25452092
Gene end: 25486010
  
Corresponding Affymetrix probe sets: Dr.2830.1.A1_at (Zebrafish Array)   NM_001002222_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000020114
NCBI entrez gene - 431769     See in Manteia.
RefSeq - NM_001002222
RefSeq Peptide - NP_001002222
swissprot - F1QZR2
ZFIN ID - ZDB-GENE-040704-69
Ensembl - ENSDARG00000018110
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PAK4ENSGALG00000031328Gallus gallus
 PAK4ENSG00000130669Homo sapiens
 Pak4ENSMUSG00000030602Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pak7 / p21 protein (Cdc42/Rac)-activated kinase 7 / PAK5* / Q8C015* / Q9P286* / p21 (RAC1) activated kinase 5* / Serine/threonine-protein kinase PAK 5 *ENSDARG0000003015449
pak6a / p21 protein (Cdc42/Rac)-activated kinase 6a / PAK6* / Q9NQU5* / BUB1B-PAK6* / BUB1B-PAK6 readthrough* / p21 (RAC1) activated kinase 6*ENSDARG0000002756445
pak6b / p21 protein (Cdc42/Rac)-activated kinase 6b / PAK6* / Q9NQU5* / Q3ULB5* / BUB1B-PAK6* / BUB1B-PAK6 readthrough* / p21 (RAC1) activated kinase 6* / Serine/threonine-protein kinase PAK 6 *ENSDARG0000005240542
pak1 / p21 protein (Cdc42/Rac)-activated kinase 1ENSDARG0000010395928
pak2a / p21 protein (Cdc42/Rac)-activated kinase 2a / PAK2* / Q13177* / Q8CIN4* / p21 (RAC1) activated kinase 2* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*ENSDARG0000006817727
pak2b / p21 protein (Cdc42/Rac)-activated kinase 2b / PAK2* / Q13177* / Q8CIN4* / p21 (RAC1) activated kinase 2* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*ENSDARG0000001847627
taok1a / TAO kinase 1a / TAOK1* / Q7L7X3* / Q5F2E8* / TAO kinase 1*ENSDARG0000006960317
taok1b / TAO kinase 1b / TAOK1* / Q7L7X3* / Q5F2E8* / TAO kinase 1*ENSDARG0000009830417
taok2a / TAO kinase 2a / TAOK2* / Q9UL54* / Q6ZQ29* / TAO kinase 2* / Serine/threonine-protein kinase TAO2 *ENSDARG0000007489917
taok2b / TAO kinase 2b / TAOK2* / Q9UL54* / Q6ZQ29* / TAO kinase 2* / Serine/threonine-protein kinase TAO2 *ENSDARG0000010062017
taok3a / TAO kinase 3a / TAOK3* / Q9H2K8* / Q8BYC6* / TAO kinase 3*ENSDARG0000006075116
taok3b / TAO kinase 3bENSDARG000000940521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033923  p21 activated kinase binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002573 myeloid leukocyte differentiation IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007266 Rho protein signal transduction IBA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030036 actin cytoskeleton organization IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0048598 embryonic morphogenesis IMP
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0048365 Rac GTPase binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood accumulation cranial vasculature , abnormal
blood accumulation trunk vasculature , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000155 somite somite malformed , abnormal
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 ZFA:0001057 intersegmental vein intersegmental vein absent , abnormal
intersegmental vein decreased length , abnormal
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 ZFA:0001094 whole organism whole organism anterior-posterior axis shortened , abnormal
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 ZFA:0001114 head head decreased size , abnormal
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 ZFA:0001458 cranial cartilage cranial cartilage morphology , abnormal
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 ZFA:0009326 myeloid leukocyte myeloid leukocyte decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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