ENSDARG00000103959


Danio rerio

Features
Gene ID: ENSDARG00000103959
  
Biological name :pak1
  
Synonyms : p21 protein (Cdc42/Rac)-activated kinase 1 / pak1
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 18
Strand: 1
Band:
Gene start: 3169579
Gene end: 3286769
  
Corresponding Affymetrix probe sets: Dr.7629.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000132462
Ensembl peptide - ENSDARP00000148256
Ensembl peptide - ENSDARP00000146047
Ensembl peptide - ENSDARP00000132912
Ensembl peptide - ENSDARP00000130006
NCBI entrez gene - 373103     See in Manteia.
swissprot - A0A0R4IH73
swissprot - A0A0R4IC19
swissprot - A0A0R4I9P4
ZFIN ID - ZDB-GENE-030826-29
Ensembl - ENSDARG00000103959
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pak2b / p21 protein (Cdc42/Rac)-activated kinase 2b / PAK2* / Q13177* / Q8CIN4* / p21 (RAC1) activated kinase 2* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*ENSDARG0000001847669
pak2a / p21 protein (Cdc42/Rac)-activated kinase 2a / PAK2* / Q13177* / Q8CIN4* / p21 (RAC1) activated kinase 2* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*ENSDARG0000006817769
pak4 / p21 protein (Cdc42/Rac)-activated kinase 4 / Q8BTW9* / O96013* / p21 (RAC1) activated kinase 4* / Serine/threonine-protein kinase PAK 4 *ENSDARG0000001811032
pak7 / p21 protein (Cdc42/Rac)-activated kinase 7 / PAK5* / Q8C015* / Q9P286* / p21 (RAC1) activated kinase 5* / Serine/threonine-protein kinase PAK 5 *ENSDARG0000003015430
pak6a / p21 protein (Cdc42/Rac)-activated kinase 6a / PAK6* / Q9NQU5* / BUB1B-PAK6* / BUB1B-PAK6 readthrough* / p21 (RAC1) activated kinase 6*ENSDARG0000002756430
pak6b / p21 protein (Cdc42/Rac)-activated kinase 6b / PAK6* / Q9NQU5* / Q3ULB5* / BUB1B-PAK6* / BUB1B-PAK6 readthrough* / p21 (RAC1) activated kinase 6* / Serine/threonine-protein kinase PAK 6 *ENSDARG0000005240530
taok2b / TAO kinase 2b / TAOK2* / Q9UL54* / Q6ZQ29* / TAO kinase 2* / Serine/threonine-protein kinase TAO2 *ENSDARG0000010062022
taok1a / TAO kinase 1a / TAOK1* / Q7L7X3* / Q5F2E8* / TAO kinase 1*ENSDARG0000006960321
taok1b / TAO kinase 1b / TAOK1* / Q7L7X3* / Q5F2E8* / TAO kinase 1*ENSDARG0000009830421
taok2a / TAO kinase 2a / TAOK2* / Q9UL54* / Q6ZQ29* / TAO kinase 2* / Serine/threonine-protein kinase TAO2 *ENSDARG0000007489920
taok3a / TAO kinase 3a / TAOK3* / Q9H2K8* / Q8BYC6* / TAO kinase 3*ENSDARG0000006075120
taok3b / TAO kinase 3bENSDARG000000940521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033923  p21 activated kinase binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001755 neural crest cell migration IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003232 bulbus arteriosus development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0044332 Wnt signaling pathway involved in dorsal/ventral axis specification IGI
 biological_processGO:0048703 embryonic viscerocranium morphogenesis IMP
 biological_processGO:0060026 convergent extension IMP
 biological_processGO:0060070 canonical Wnt signaling pathway IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood accumulation heart , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000114 heart heart morphology , abnormal
heart edematous , abnormal
Show

 ZFA:0000173 bulbus arteriosus bulbus arteriosus morphology , abnormal
Show

 ZFA:0000471 atrium atrium morphology , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased length , abnormal
whole organism semi-lethal (sensu genetics) , abnormal
whole organism curved , abnormal
whole organism lacks parts or has fewer parts of type portion of tissue , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
head cell death increased process quality , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage morphology , abnormal
Show

 ZFA:0001306 pharyngeal arch pharyngeal arch morphology , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage kinked , abnormal
ceratohyal cartilage morphology , abnormal
Show

 ZFA:0001458 cranial cartilage cranial cartilage malformed , abnormal
Show

 ZFA:0009091 melanocyte melanocyte decreased amount , abnormal
melanocyte neural crest cell migration process quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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