ENSDARG00000068177


Danio rerio

Features
Gene ID: ENSDARG00000068177
  
Biological name :pak2a
  
Synonyms : p21 protein (Cdc42/Rac)-activated kinase 2a / pak2a
  
Possible biological names infered from orthology : p21 (RAC1) activated kinase 2 / PAK2 / Q13177 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 36608387
Gene end: 36636866
  
Corresponding Affymetrix probe sets: Dr.17502.1.A1_at (Zebrafish Array)   Dr.8824.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000137398
Ensembl peptide - ENSDARP00000144014
Ensembl peptide - ENSDARP00000137659
Ensembl peptide - ENSDARP00000089188
NCBI entrez gene - 266749     See in Manteia.
RefSeq - NM_001002717
RefSeq Peptide - NP_001002717
swissprot - A0A0R4IRH8
swissprot - A0A0R4IQG0
swissprot - Q6DG42
ZFIN ID - ZDB-GENE-021011-2
Ensembl - ENSDARG00000068177
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PAK2ENSGALG00000006426Gallus gallus
 PAK2ENSG00000180370Homo sapiens
 Pak2ENSMUSG00000022781Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pak2b / p21 protein (Cdc42/Rac)-activated kinase 2b / PAK2* / Q13177* / Q8CIN4* / p21 (RAC1) activated kinase 2* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*ENSDARG0000001847689
pak1 / p21 protein (Cdc42/Rac)-activated kinase 1ENSDARG0000010395978
pak4 / p21 protein (Cdc42/Rac)-activated kinase 4 / Q8BTW9* / O96013* / p21 (RAC1) activated kinase 4* / Serine/threonine-protein kinase PAK 4 *ENSDARG0000001811035
pak6a / p21 protein (Cdc42/Rac)-activated kinase 6a / PAK6* / Q9NQU5* / BUB1B-PAK6* / BUB1B-PAK6 readthrough* / p21 (RAC1) activated kinase 6*ENSDARG0000002756433
pak6b / p21 protein (Cdc42/Rac)-activated kinase 6b / PAK6* / Q9NQU5* / Q3ULB5* / BUB1B-PAK6* / BUB1B-PAK6 readthrough* / p21 (RAC1) activated kinase 6* / Serine/threonine-protein kinase PAK 6 *ENSDARG0000005240532
pak7 / p21 protein (Cdc42/Rac)-activated kinase 7 / PAK5* / Q8C015* / Q9P286* / p21 (RAC1) activated kinase 5* / Serine/threonine-protein kinase PAK 5 *ENSDARG0000003015431
taok1b / TAO kinase 1b / TAOK1* / Q7L7X3* / Q5F2E8* / TAO kinase 1*ENSDARG0000009830424
taok1a / TAO kinase 1a / TAOK1* / Q7L7X3* / Q5F2E8* / TAO kinase 1*ENSDARG0000006960324
taok2b / TAO kinase 2b / TAOK2* / Q9UL54* / Q6ZQ29* / TAO kinase 2* / Serine/threonine-protein kinase TAO2 *ENSDARG0000010062023
taok2a / TAO kinase 2a / TAOK2* / Q9UL54* / Q6ZQ29* / TAO kinase 2* / Serine/threonine-protein kinase TAO2 *ENSDARG0000007489923
taok3a / TAO kinase 3a / TAOK3* / Q9H2K8* / Q8BYC6* / TAO kinase 3*ENSDARG0000006075122
taok3b / TAO kinase 3bENSDARG000000940521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033923  p21 activated kinase binding domain
 IPR035064  p21-activated kinase 2, catalytic domain
 IPR035065  Serine/threonine-protein kinase PAK2/3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IMP
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007266 Rho protein signal transduction IBA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030036 actin cytoskeleton organization IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0048365 Rac GTPase binding IBA


Pathways (from Reactome)
Pathway description
Generation of second messenger molecules
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hemorrhagic , abnormal
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 ZFA:0000099 brain vasculature brain vasculature fragile , abnormal
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 ZFA:0001267 cranial vasculature cranial vasculature fragile , abnormal
cranial vasculature hemorrhagic , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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