ENSDARG00000018476


Danio rerio

Features
Gene ID: ENSDARG00000018476
  
Biological name :pak2b
  
Synonyms : p21 protein (Cdc42/Rac)-activated kinase 2b / pak2b
  
Possible biological names infered from orthology : p21 (RAC1) activated kinase 2 / PAK2 / Q13177 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 2895511
Gene end: 2929156
  
Corresponding Affymetrix probe sets: Dr.10833.1.A1_at (Zebrafish Array)   NM_001025456_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000046677
Ensembl peptide - ENSDARP00000143950
Ensembl peptide - ENSDARP00000104638
NCBI entrez gene - 325034     See in Manteia.
RefSeq - NM_001025456
RefSeq Peptide - NP_001020627
swissprot - A5WVS3
swissprot - A5WVS2
swissprot - A0A286YAF5
ZFIN ID - ZDB-GENE-030131-3759
Ensembl - ENSDARG00000018476
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PAK2ENSGALG00000006426Gallus gallus
 PAK2ENSG00000180370Homo sapiens
 Pak2ENSMUSG00000022781Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pak2a / p21 protein (Cdc42/Rac)-activated kinase 2a / PAK2* / Q13177* / Q8CIN4* / p21 (RAC1) activated kinase 2* / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34*ENSDARG0000006817786
pak1 / p21 protein (Cdc42/Rac)-activated kinase 1ENSDARG0000010395975
pak6a / p21 protein (Cdc42/Rac)-activated kinase 6a / PAK6* / Q9NQU5* / BUB1B-PAK6* / BUB1B-PAK6 readthrough* / p21 (RAC1) activated kinase 6*ENSDARG0000002756433
pak4 / p21 protein (Cdc42/Rac)-activated kinase 4 / Q8BTW9* / O96013* / p21 (RAC1) activated kinase 4* / Serine/threonine-protein kinase PAK 4 *ENSDARG0000001811033
pak6b / p21 protein (Cdc42/Rac)-activated kinase 6b / PAK6* / Q9NQU5* / Q3ULB5* / BUB1B-PAK6* / BUB1B-PAK6 readthrough* / p21 (RAC1) activated kinase 6* / Serine/threonine-protein kinase PAK 6 *ENSDARG0000005240531
pak7 / p21 protein (Cdc42/Rac)-activated kinase 7 / PAK5* / Q8C015* / Q9P286* / p21 (RAC1) activated kinase 5* / Serine/threonine-protein kinase PAK 5 *ENSDARG0000003015430
taok2b / TAO kinase 2b / TAOK2* / Q9UL54* / Q6ZQ29* / TAO kinase 2* / Serine/threonine-protein kinase TAO2 *ENSDARG0000010062023
taok1b / TAO kinase 1b / TAOK1* / Q7L7X3* / Q5F2E8* / TAO kinase 1*ENSDARG0000009830423
taok1a / TAO kinase 1a / TAOK1* / Q7L7X3* / Q5F2E8* / TAO kinase 1*ENSDARG0000006960323
taok2a / TAO kinase 2a / TAOK2* / Q9UL54* / Q6ZQ29* / TAO kinase 2* / Serine/threonine-protein kinase TAO2 *ENSDARG0000007489922
taok3a / TAO kinase 3a / TAOK3* / Q9H2K8* / Q8BYC6* / TAO kinase 3*ENSDARG0000006075121
taok3b / TAO kinase 3bENSDARG000000940521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033923  p21 activated kinase binding domain
 IPR035064  p21-activated kinase 2, catalytic domain
 IPR035065  Serine/threonine-protein kinase PAK2/3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001568 blood vessel development IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Generation of second messenger molecules
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000099 brain vasculature brain vasculature hemorrhagic , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr