ENSMUSG00000022781


Mus musculus

Features
Gene ID: ENSMUSG00000022781
  
Biological name :Pak2
  
Synonyms : Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34
  
Possible biological names infered from orthology : p21 (RAC1) activated kinase 2 / Q13177
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: B2
Gene start: 32016290
Gene end: 32079342
  
Corresponding Affymetrix probe sets: 10439032 (MoGene1.0st)   1430627_at (Mouse Genome 430 2.0 Array)   1434250_at (Mouse Genome 430 2.0 Array)   1454887_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023467
NCBI entrez gene - 224105     See in Manteia.
MGI - MGI:1339984
RefSeq - NM_177326
RefSeq - XM_006522072
RefSeq Peptide - NP_796300
swissprot - Q8CIN4
Ensembl - ENSMUSG00000022781
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pak2aENSDARG00000068177Danio rerio
 pak2bENSDARG00000018476Danio rerio
 PAK2ENSGALG00000006426Gallus gallus
 PAK2ENSG00000180370Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*ENSMUSG0000003128478
Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*ENSMUSG0000003077478
Pak7 / Q8C015 / Serine/threonine-protein kinase PAK 5 / PAK5* / Q9P286* / p21 (RAC1) activated kinase 5*ENSMUSG0000003991337
Pak4 / Q8BTW9 / Serine/threonine-protein kinase PAK 4 / O96013* / p21 (RAC1) activated kinase 4*ENSMUSG0000003060236
Pak6 / Q3ULB5 / Serine/threonine-protein kinase PAK 6 / Q9NQU5* / BUB1B-PAK6* / BUB1B-PAK6 readthrough* / p21 (RAC1) activated kinase 6*ENSMUSG0000007492335
Taok1 / Q5F2E8 / TAO kinase 1 / Q7L7X3*ENSMUSG0000001729123
Taok2 / Q6ZQ29 / Serine/threonine-protein kinase TAO2 / Q9UL54* / TAO kinase 2*ENSMUSG0000005998123
Taok3 / Q8BYC6 / TAO kinase 3 / Q9H2K8*ENSMUSG0000006128822


Protein motifs (from Interpro)
Interpro ID Name
 IPR000095  CRIB domain
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR033923  p21 activated kinase binding domain
 IPR035064  p21-activated kinase 2, catalytic domain
 IPR035065  Serine/threonine-protein kinase PAK2/3
 IPR036936  CRIB domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007266 Rho protein signal transduction IBA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0016310 phosphorylation ISO
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030036 actin cytoskeleton organization IBA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0060996 dendritic spine development IGI
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IEA
 biological_processGO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030296 protein tyrosine kinase activator activity IEA
 molecular_functionGO:0031267 small GTPase binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
Generation of second messenger molecules
FCERI mediated MAPK activation
CD28 dependent Vav1 pathway
Ephrin signaling
Sema3A PAK dependent Axon repulsion
VEGFA-VEGFR2 Pathway
Smooth Muscle Contraction
VEGFR2 mediated vascular permeability
CD209 (DC-SIGN) signaling
RHO GTPases activate PAKs
MAPK6/MAPK4 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000313 abnormal cell death "anomalous cessation of function at the cellular level" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0009768 impaired somite development "atypical process of somite formation with the result of fewer or none of these cell masses being formed" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm2.1Brn/Cdkn2atm2.1Brn,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

Allelic Composition: Pak2tm1Dgen/Pak2tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011703 increased fibroblast proliferation "greater the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: Fgfr1Hspy/Fgfr1+
Genetic Background: (C3HeB/FeJ-Fgfr1Hspy x C57BL/6J)F1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031398 P70208 / Plxna3 / plexin A3 / P51805*  / reaction / complex
 ENSMUSG00000034116 Vav1 / P27870 / vav 1 oncogene / P15498* / vav guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000026640 P70207 / Plxna2 / Plexin-A2 / O75051*  / complex / reaction
 ENSMUSG00000023951 Vegfa / Q00731 / vascular endothelial growth factor A / P15692*  / complex / reaction
 ENSMUSG00000025810 Nrp1 / P97333 / Neuropilin-1 / O14786*  / reaction / complex
 ENSMUSG00000031871 Cdh5 / P55284 / Cadherin-5 / P33151*  / reaction
 ENSMUSG00000029674 Limk1 / P53668 / LIM domain kinase 1 / P53667*  / reaction
 ENSMUSG00000018830 Myh11 / myosin heavy chain 11 / P35749*  / reaction
 ENSMUSG00000025499 Hras / Q61411 / GTPase HRas GTPase HRas, N-terminally processed / P01112* / HRas proto-oncogene, GTPase*  / reaction
 ENSMUSG00000019843 Fyn / P39688 / Tyrosine-protein kinase Fyn / P06241* / FYN proto-oncogene, Src family tyrosine kinase*  / complex / reaction
 ENSMUSG00000053158 Fes / P16879 / Tyrosine-protein kinase Fes/Fps / P07332* / FES proto-oncogene, tyrosine kinase*  / complex / reaction
 ENSMUSG00000034868 Myl12b / Q3THE2 / Myosin regulatory light chain 12B / O14950* / myosin light chain 12B*  / reaction
 ENSMUSG00000001847 Rac1 / P63001 / RAS-related C3 botulinum substrate 1 / P63000* / Rac family small GTPase 1*  / reaction / complex
 ENSMUSG00000028883 O08665 / Sema3a / Semaphorin-3A / Q14563*  / complex / reaction
 ENSMUSG00000030084 P70206 / Plxna1 / Plexin-A1 / Q9UIW2*  / complex / reaction
 ENSMUSG00000059923 Grb2 / Q60631 / Growth factor receptor-bound protein 2 / P62993*  / complex / reaction
 ENSMUSG00000033721 Vav3 / Q9R0C8 / vav 3 oncogene / Q9UKW4* / vav guanine nucleotide exchange factor 3*  / reaction / complex
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction
 ENSMUSG00000024241 Sos1 / Q62245 / Son of sevenless homolog 1 / Q07889* / SOS Ras/Rac guanine nucleotide exchange factor 1*  / complex / reaction
 ENSMUSG00000022443 Myh9 / Q8VDD5 / myosin, heavy polypeptide 9, non-muscle / P35579* / myosin heavy chain 9*  / reaction
 ENSMUSG00000037815 Ctnna1 / P26231 / Catenin alpha-1 / P35221*  / reaction
 ENSMUSG00000066877 Nck2 / O55033 / Cytoplasmic protein NCK2 / O43639* / NCK adaptor protein 2*  / complex / reaction
 ENSMUSG00000062960 Kdr / kinase insert domain receptor / P35968*  / complex / reaction
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / complex / reaction
 ENSMUSG00000024558 Mapk4 / Q6P5G0 / Mitogen-activated protein kinase 4 / P31152*  / reaction
 ENSMUSG00000016933 Plcg1 / Q62077 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 / P19174* / phospholipase C gamma 1*  / reaction / complex
 ENSMUSG00000034330 Plcg2 / Q8CIH5 / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 / P16885* / phospholipase C gamma 2*  / complex / reaction
 ENSMUSG00000002699 Lcp2 / Q60787 / Lymphocyte cytosolic protein 2 / Q13094*  / complex / reaction
 ENSMUSG00000009621 Vav2 / Q60992 / vav 2 oncogene / P52735* / vav guanine nucleotide exchange factor 2*  / reaction / complex
 ENSMUSG00000030742 Lat / O54957 / Linker for activation of T-cells family member 1 / O43561* / linker for activation of T cells*  / reaction / complex
 ENSMUSG00000020900 Myh10 / Q61879 / Myosin-10 / P35580* / myosin heavy chain 10*  / reaction
 ENSMUSG00000030739 Myh14 / Q6URW6 / Myosin-14 / Q7Z406* / myosin heavy chain 14*  / reaction
 ENSMUSG00000029765 Plxna4 / Q80UG2 / plexin A4 / Q9HCM2*  / complex / reaction
 ENSMUSG00000032475 Nck1 / Q99M51 / Cytoplasmic protein NCK1 / P16333* / NCK adaptor protein 1*  / complex / reaction
 ENSMUSG00000042351 Grap2 / O89100 / GRB2-related adaptor protein 2 / O75791*  / reaction / complex
 ENSMUSG00000030265 Kras / P32883 / GTPase KRas GTPase KRas, N-terminally processed / P01116* / KRAS proto-oncogene, GTPase*  / reaction
 ENSMUSG00000001552 Jup / Q02257 / Junction plakoglobin / P14923*  / reaction
 ENSMUSG00000090841 Myl6 / Q60605 / myosin, light polypeptide 6, alkali, smooth muscle and non-muscle / P60660* / myosin light chain 6*  / reaction
 ENSMUSG00000042626 Shc1 / P98083 / SHC-transforming protein 1 / P29353* / SHC adaptor protein 1*  / reaction / complex
 ENSMUSG00000042688 Mapk6 / Q61532 / Mitogen-activated protein kinase 6 / Q16659*  / reaction
 ENSMUSG00000101645 P30999 / Gm28635 / predicted gene 28635 / O60716* / CTNND1* / catenin delta 1*  / reaction
 ENSMUSG00000000441 Raf1 / Q99N57 / Mus musculus v-raf-leukemia viral onco 1 (Raf1), transcript variant 3, mRNA. / P04049* / Raf-1 proto-oncogene, serine/threonine kinase*  / reaction
 ENSMUSG00000031284 Pak3 / Q61036 / Serine/threonine-protein kinase PAK 3 / O75914* / p21 (RAC1) activated kinase 3*  / reaction
 ENSMUSG00000022836 Mylk / myosin light chain kinase / Q15746*  / reaction






 

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