ENSMUSG00000020900


Mus musculus

Features
Gene ID: ENSMUSG00000020900
  
Biological name :Myh10
  
Synonyms : Myh10 / Myosin-10 / Q61879
  
Possible biological names infered from orthology : myosin heavy chain 10 / P35580
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B3
Gene start: 68691559
Gene end: 68816632
  
Corresponding Affymetrix probe sets: 10377319 (MoGene1.0st)   1441057_at (Mouse Genome 430 2.0 Array)   1452740_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018887
Ensembl peptide - ENSMUSP00000090661
Ensembl peptide - ENSMUSP00000099671
Ensembl peptide - ENSMUSP00000104313
NCBI entrez gene - 77579     See in Manteia.
MGI - MGI:1930780
RefSeq - XM_017314835
RefSeq - NM_175260
RefSeq - XM_006534489
RefSeq - XM_017314834
RefSeq Peptide - NP_780469
swissprot - Q61879
swissprot - Q8BXF2
swissprot - Q3UH59
swissprot - Q5SV64
Ensembl - ENSMUSG00000020900
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myh10ENSDARG00000000103Danio rerio
 MYH10ENSGALG00000001183Gallus gallus
 MYH10ENSG00000133026Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myh9 / Q8VDD5 / myosin, heavy polypeptide 9, non-muscle / P35579* / myosin heavy chain 9*ENSMUSG0000002244377
Myh11 / myosin heavy chain 11 / P35749*ENSMUSG0000001883074
Myh14 / Q6URW6 / Myosin-14 / Q7Z406* / myosin heavy chain 14*ENSMUSG0000003073966
Myh7 / Q91Z83 / Myosin-7 / P12883* / myosin heavy chain 7*ENSMUSG0000005309340
Myh3 / P13541 / Myosin-3 / P11055* / myosin heavy chain 3*ENSMUSG0000002090840
Myh7b / A2AQP0 / Myosin-7B / A7E2Y1* / myosin heavy chain 7B*ENSMUSG0000007465240
Myh2 / myosin heavy chain 2 / Q9UKX2*ENSMUSG0000003319640
Myh8 / P13542 / Myosin-8 / P13535* / myosin heavy chain 8*ENSMUSG0000005577540
Myh4 / Q5SX39 / Myosin-4 / Q9Y623* / myosin heavy chain 4*ENSMUSG0000005700339
Myh6 / Q02566 / myosin, heavy polypeptide 6, cardiac muscle, alpha / P13533* / myosin heavy chain 6*ENSMUSG0000004075239
Myh1 / Q5SX40 / Myosin-1 / P12882* / myosin heavy chain 1*ENSMUSG0000005632839
Myh13 / myosin heavy chain 13 / Q9UKX3*ENSMUSG0000006018039
Myh15 / myosin heavy chain 15 / Q9Y2K3*ENSMUSG0000009200935


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001609  Myosin head, motor domain
 IPR002928  Myosin tail
 IPR004009  Myosin, N-terminal, SH3-like
 IPR008989  Myosin S1 fragment, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001764 neuron migration IMP
 biological_processGO:0001778 plasma membrane repair IMP
 biological_processGO:0003279 cardiac septum development IMP
 biological_processGO:0006887 exocytosis IMP
 biological_processGO:0006930 substrate-dependent cell migration, cell extension IMP
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0007097 nuclear migration IMP
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007411 axon guidance IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007512 adult heart development IMP
 biological_processGO:0008283 cell proliferation IMP
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0021592 fourth ventricle development IMP
 biological_processGO:0021670 lateral ventricle development IMP
 biological_processGO:0021678 third ventricle development IMP
 biological_processGO:0021680 cerebellar Purkinje cell layer development IMP
 biological_processGO:0030036 actin cytoskeleton organization IGI
 biological_processGO:0030048 actin filament-based movement IEA
 biological_processGO:0030239 myofibril assembly IMP
 biological_processGO:0031032 actomyosin structure organization IEA
 biological_processGO:0031175 neuron projection development IMP
 biological_processGO:0035904 aorta development IMP
 biological_processGO:0050714 positive regulation of protein secretion IEA
 biological_processGO:0050885 neuromuscular process controlling balance IMP
 biological_processGO:0055003 cardiac myofibril assembly IMP
 biological_processGO:0055015 ventricular cardiac muscle cell development IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0060976 coronary vasculature development IMP
 biological_processGO:0098885 modification of postsynaptic actin cytoskeleton IEA
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0016460 myosin II complex IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030426 growth cone IDA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0031594 neuromuscular junction IDA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0042641 actomyosin IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0043025 neuronal cell body IDA
 cellular_componentGO:0043197 dendritic spine IDA
 cellular_componentGO:0097513 myosin II filament IEA
 molecular_functionGO:0000146 microfilament motor activity IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0030898 actin-dependent ATPase activity IEA
 molecular_functionGO:0035613 RNA stem-loop binding IEA
 molecular_functionGO:0043531 ADP binding IEA
 molecular_functionGO:0048027 mRNA 5"-UTR binding IEA
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10ehc/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Myh10b2b2437Clo/Myh10b2b2437Clo
Genetic Background: C57BL/6J-Myh10b2b2437Clo

 MP:0000277 abnormal heart shape "malformation of the form or the patterning of the heart" [J:18048]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000279 ventricular hypoplasia "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
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Allelic Composition: Mcl1tm1Ywh/Mcl1tm1Ywh,Tg(Lck-cre)548Jxm/0
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Myh10b2b2437Clo/Myh10b2b2437Clo
Genetic Background: C57BL/6J-Myh10b2b2437Clo

Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tg(JAK2*V617F)FF1Rsko/0,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

 MP:0000440 domed skull 
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
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Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000827 dilated third ventricle "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000828 abnormal fourth ventricle morphology "malformed or absent irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind; it is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Myh10tm2Rsad/Myh10tm4Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm2Rsad/Myh10tm5Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0000849 abnormal cerebellum morphology "any malformation or absence of the part of the metencephalon that lies in the posterior cranial fossa dorsal to the pons and medulla that is concerned with the coordination of movement and learning of motor skills" [J:50311, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000852 small cerebellum "reduced size of cerebellum" [MGI:CLS, J:17203, J:67524]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000854 abnormal cerebellum development "malformed or incomplete differentiation of the part of the metencephalon that lies dorsal to the pons and medulla behind the brain stem and controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ttntm2.1Mgot/Ttn+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm6(Myh9/GFP)Rsad/Myh10tm6(Myh9/GFP)Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000872 abnormal external granule cell layer "malformation of the transient layer of the cerebellar cortex which is composed of the dividing and migrating granule cells" [tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000875 abnormal cerebellar Purkinje cell layer "any malformation or absence of the cell layer that lies just underneath the molecular layer of the cerebellar cortex; it contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer, and candelabrum interneurons are vertically oriented between the Purkinje cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm5Rsad/Myh10tm5Rsad,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0000877 abnormal Purkinje cell "any structural anomaly of the neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex; these inhibitory neurons provide the output of the cerebellar cortex through axons that project into the white matter, and extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells" [J:46140, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm5Rsad/Myh10tm5Rsad,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0000886 abnormal cerebellar granule layer "any malformation or absence of the innermost cortical layer of the cerebellum; contains densly packed small neurons, mostly granule cells with some Golgi cells are found at the outer border" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Tg(JAK2*V617F)FF1Rsko/0,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: C57BL/6 * C57BL/10 * CBA/Ca

 MP:0000955 abnormal spinal cord morphology "malformation or disorganization of the cylindrical tissue of the vertebral canal that extends from the medulla oblongata to the conus medullaris" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ttntm2.1Mgot/Ttn+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * SJL

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Hrrhsl/Hrrhsl
Genetic Background: involves: BALB/c

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm5Rsad/Myh10tm5Rsad,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Hrrhsl/Hrrhsl
Genetic Background: involves: BALB/c

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Myh10tm1Rsad/Myh10tm1Rsad
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Myh10tm1Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Myh10tm6(Myh9/GFP)Rsad/Myh10tm6(Myh9/GFP)Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
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Allelic Composition: Kiss1rtm1.1(KOMP)Vlcg/Kiss1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Kiss1rtm1.1(KOMP)Vlcg/Ucd

Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Myh10tm2Rsad/Myh10tm4Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm2Rsad/Myh10tm5Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kiss1rtm1.1(KOMP)Vlcg/Kiss1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Kiss1rtm1.1(KOMP)Vlcg/Ucd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Dicer1em3Psv/Dicer1em3Psv
Genetic Background: involves: C57BL/6NCrl

 MP:0002639 micrognathia "abnormally reduced size of the jaws, especially of the mandible" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Myh10b2b2437Clo/Myh10b2b2437Clo
Genetic Background: C57BL/6J-Myh10b2b2437Clo

 MP:0002747 abnormal aortic valve morphology "malformation of the valve between the left ventricle and the ascending aorta" [J:82728, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myh10tm6(Myh9/GFP)Rsad/Myh10tm6(Myh9/GFP)Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kiss1rtm1.1(KOMP)Vlcg/Kiss1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Kiss1rtm1.1(KOMP)Vlcg/Ucd

 MP:0003105 abnormal heart atrium morphology "structural anomaly of one or both of the two upper chambers of the heart " [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003956 abnormal body size "anomaly in the average body weight, height and/or length of an organism compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004056 abnormal myocardial compact layer morphology "malformation of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Myh10b2b2437Clo/Myh10b2b2437Clo
Genetic Background: C57BL/6J-Myh10b2b2437Clo

Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Myh10ehc/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0004062 dilated right atrium "an expansion in the volume of the right upper chamber of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0004258 abnormal placenta size "anomaly in the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kiss1rtm1.1(KOMP)Vlcg/Kiss1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Kiss1rtm1.1(KOMP)Vlcg/Ucd

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Myh10tm6(Myh9/GFP)Rsad/Myh10tm6(Myh9/GFP)Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myh10tm6(Myh9/GFP)Rsad/Myh10tm6(Myh9/GFP)Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005170 cleft lip "defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myh10b2b2437Clo/Myh10b2b2437Clo
Genetic Background: C57BL/6J-Myh10b2b2437Clo

 MP:0005244 hemopericardium "bleeding into the pericardial space" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Kiss1rtm1.1(KOMP)Vlcg/Kiss1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Kiss1rtm1.1(KOMP)Vlcg/Ucd

 MP:0005294 abnormal heart ventricle morphology "structural anomaly of one or both of the two lower chambers of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0005330 cardiomyopathy "diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]
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Allelic Composition: Aestm1.1Mmt/Aestm1.1Mmt,Apctm1Mmt/Apc+,Tg(Vil-cre/ERT2)23Syr/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * DBA * SJL

Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0005537 abnormal cerebral aqueduct "anomalous structure of the channel in the mesencephalon that connets the third and fourth ventricles" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Myh10tm6(Myh9/GFP)Rsad/Myh10tm6(Myh9/GFP)Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm6(Myh9/GFP)Rsad/Myh10tm6(Myh9/GFP)Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0006073 abnormal retinal bipolar cell morphology "anomalous structure of the cells that transmit signals from the photoreceptors to retinal amacrine and ganglion cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623:]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0006254 thin cerebral cortex "decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]
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Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0006267 abnormal intercalated disc morphology "any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]
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Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0008535 enlarged lateral ventricles "increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0008572 abnormal Purkinje cell dendrite morphology "any strucutral anomaly of the Purkinje cell body projections with hundreds of parallel spiny branches reaching up into the molecular layer" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm5Rsad/Myh10tm5Rsad,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh10tm6(Myh9/GFP)Rsad/Myh10tm6(Myh9/GFP)Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008788 abnormal fetal cardiomyocyte morphology "any structural anomaly of fetal and neonatal heart cells that undergo proliferation and are not yet terminally differentiated into binucleate or multinucleate cardiac myocytes" [PMID:17429040]
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Allelic Composition: Myh10tm6(Myh9/GFP)Rsad/Myh10tm6(Myh9/GFP)Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0009688 abnormal spinal cord central canal morphology "any structural anomaly of the ependyma-lined lumen of the spinal cord that is filled with cerebrospinal fluid; it is patent with the ventricular system of the brain and frequently becomes occluded in aging adults" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0009698 heart hemorrhage "bleeding into the heart" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
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Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
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Allelic Composition: Myh10tm6(Myh9/GFP)Rsad/Myh10tm6(Myh9/GFP)Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

Allelic Composition: Myh10b2b2437Clo/Myh10b2b2437Clo
Genetic Background: C57BL/6J-Myh10b2b2437Clo

Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0010412 atrioventricular septal defect "defects in the thin membranous structure between the right atrium and left ventricle that arise from faulty development of the embryonic endocardial cushions; the spectrum ranges from a primum atrial septal defect and cleft mitral valve, known as a partial atrioventricular septal defect (partial AVSD), to defects of both the primum atrial septum and inlet ventricular septum and the presence of a common atrioventricular valve, referred to as complete atrioventricular septal defect (complete AVSD)" [http://emedicine.medscape.com]
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Allelic Composition: Myh10b2b2437Clo/Myh10b2b2437Clo
Genetic Background: C57BL/6J-Myh10b2b2437Clo

 MP:0010418 perimembraneous ventricular septal defect "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010449 heart right ventricle outflow tract stenosis "abnormal constriction or narrowing of part of the anteriosuperior, smooth-walled portion of the cavity of the right ventricle, beginning at the supraventricular crest and terminating in the pulmonary trunk" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010499 abnormal ventricle myocardium morphology "any structural anomaly of the ventricular part of middle layer of the heart, comprised of involuntary muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0010503 myocardial trabeculae hypoplasia "underdevelopment or reduced size of the supporting bundles of muscular fibers lining the walls of the heart, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0010561 absent coronary vessels "absence of the arteries and veins that supply blood to the heart or return blood from the heart muscles to the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Myh10ehc/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0010725 thin interventricular septum "decreased thickness of the wall between the two lower chambers of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm7Rsad/Myh10tm7Rsad,Tg(Nes-cre)1Wme/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Myh10ehc/Myh10tm2Rsad
Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Myh10tm3Rsad/Myh10tm3Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10tm2Rsad/Myh10tm2Rsad,Myh14tm1Rsad/Myh14tm1Rsad
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Kiss1rtm1.1(KOMP)Vlcg/Kiss1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Kiss1rtm1.1(KOMP)Vlcg/Ucd

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Disp1tm1Pab/Disp1tm1Pab
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
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Allelic Composition: Myh10tm6(Myh9/GFP)Rsad/Myh10tm6(Myh9/GFP)Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0011239 abnormal skin coloration "a variation in an expected skin color or complexion that may be due to inflammation, pigment defects or other causes" [MGI:llw2]
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Allelic Composition: Kiss1rtm1.1(KOMP)Vlcg/Kiss1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Kiss1rtm1.1(KOMP)Vlcg/Ucd

 MP:0011667 double outlet right ventricle with atrioventricular septal defect "a form of DORV in which there is also a complete atrioventricular canal" [MGI:csmith]
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Allelic Composition: Myh10b2b2437Clo/Myh10b2b2437Clo
Genetic Background: C57BL/6J-Myh10b2b2437Clo

 MP:0012515 abnormal heart apex morphology "any structural anomaly of the lowest superficial part of the heart, normally directed downward, forward, and to the left, and overlapped by the left lung and pleura; the heart apex is formed by the inferolateral part of the left ventricle and responsible for regulating ventricle contraction" [MGI:anna]
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Allelic Composition: Myh10ehc/Myh10ehc
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd * C57BL/6J

 MP:0012676 dilated brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna]
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Allelic Composition: Myh10tm4Rsad/Myh10tm4Rsad
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0013294 prenatal lethality prior to heart atrial septation "death prior to the completion of heart atrial septation (Mus: E14.5-15.5)" [MGI:smb]
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Allelic Composition: Kiss1rtm1.1(KOMP)Vlcg/Kiss1rtm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Kiss1rtm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022443 Myh9 / Q8VDD5 / myosin, heavy polypeptide 9, non-muscle / P35579* / myosin heavy chain 9*  / complex
 ENSMUSG00000060534 Dcc / P70211 / Netrin receptor DCC / P43146* / DCC netrin 1 receptor*  / complex / reaction
 ENSMUSG00000020900 Myh10 / Q61879 / Myosin-10 / P35580* / myosin heavy chain 10*  / complex
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction
 ENSMUSG00000034868 Myl12b / Q3THE2 / Myosin regulatory light chain 12B / O14950* / myosin light chain 12B*  / complex
 ENSMUSG00000030739 Myh14 / Q6URW6 / Myosin-14 / Q7Z406* / myosin heavy chain 14*  / complex
 ENSMUSG00000018830 Myh11 / myosin heavy chain 11 / P35749*  / complex
 ENSMUSG00000090841 Myl6 / Q60605 / myosin, light polypeptide 6, alkali, smooth muscle and non-muscle / P60660* / myosin light chain 6*  / complex






 

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