ENSMUSG00000018830


Mus musculus

Features
Gene ID: ENSMUSG00000018830
  
Biological name :Myh11
  
Synonyms : Myh11 / myosin heavy chain 11
  
Possible biological names infered from orthology : P35749
  
Species: Mus musculus
  
Chr. number: 16
Strand: -1
Band: A1
Gene start: 14194535
Gene end: 14291372
  
Corresponding Affymetrix probe sets: 10437885 (MoGene1.0st)   1418122_at (Mouse Genome 430 2.0 Array)   1448962_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000087756
Ensembl peptide - ENSMUSP00000155052
NCBI entrez gene - 17880     See in Manteia.
MGI - MGI:102643
RefSeq - XM_006521844
RefSeq - NM_001161775
RefSeq - NM_013607
RefSeq - XM_006521843
RefSeq Peptide - NP_038635
RefSeq Peptide - NP_001155247
swissprot - E9QPE7
Ensembl - ENSMUSG00000018830
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myh11aENSDARG00000009782Danio rerio
 myh11bENSDARG00000100972Danio rerio
 MYH11ENSGALG00000006520Gallus gallus
 MYH11ENSG00000133392Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myh9 / Q8VDD5 / myosin, heavy polypeptide 9, non-muscle / P35579* / myosin heavy chain 9*ENSMUSG0000002244376
Myh10 / Q61879 / Myosin-10 / P35580* / myosin heavy chain 10*ENSMUSG0000002090076
Myh14 / Q6URW6 / Myosin-14 / Q7Z406* / myosin heavy chain 14*ENSMUSG0000003073963
Myh3 / P13541 / Myosin-3 / P11055* / myosin heavy chain 3*ENSMUSG0000002090841
Myh8 / P13542 / Myosin-8 / P13535* / myosin heavy chain 8*ENSMUSG0000005577541
Myh2 / myosin heavy chain 2 / Q9UKX2*ENSMUSG0000003319641
Myh7 / Q91Z83 / Myosin-7 / P12883* / myosin heavy chain 7*ENSMUSG0000005309341
Myh1 / Q5SX40 / Myosin-1 / P12882* / myosin heavy chain 1*ENSMUSG0000005632841
Myh4 / Q5SX39 / Myosin-4 / Q9Y623* / myosin heavy chain 4*ENSMUSG0000005700340
Myh6 / Q02566 / myosin, heavy polypeptide 6, cardiac muscle, alpha / P13533* / myosin heavy chain 6*ENSMUSG0000004075240
Myh13 / myosin heavy chain 13 / Q9UKX3*ENSMUSG0000006018040
Myh7b / A2AQP0 / Myosin-7B / A7E2Y1* / myosin heavy chain 7B*ENSMUSG0000007465240
Myh15 / myosin heavy chain 15 / Q9Y2K3*ENSMUSG0000009200935


Protein motifs (from Interpro)
Interpro ID Name
 IPR000048  IQ motif, EF-hand binding site
 IPR001609  Myosin head, motor domain
 IPR002928  Myosin tail
 IPR004009  Myosin, N-terminal, SH3-like
 IPR008989  Myosin S1 fragment, N-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007018 microtubule-based movement IEA
 biological_processGO:0048251 elastic fiber assembly IMP
 biological_processGO:0048739 cardiac muscle fiber development IMP
 cellular_componentGO:0016459 myosin complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003774 motor activity IEA
 molecular_functionGO:0003777 microtubule motor activity IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0008307 structural constituent of muscle IMP
 molecular_functionGO:0051015 actin filament binding IEA


Pathways (from Reactome)
Pathway description
Smooth Muscle Contraction
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000364 abnormal vascular regression "premature regression or persistence of vessels programmed to regress and/or loss of vessels not programmed to regress" [smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Arfrp1tm2Asch/Arfrp1tm2Asch,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Myh11tm2Peri/Myh11tm2Peri
Genetic Background: involves: 129 * C57BL/6

 MP:0000538 abnormal urinary bladder morphology "malformation of the inflatable musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000539 distended urinary bladder "stretched musculomembranous bag for holding urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Myh11tm2Peri/Myh11tm2Peri
Genetic Background: involves: 129 * C57BL/6

 MP:0000740 impaired smooth muscle contractility "inability or reduced ability of the smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

Allelic Composition: Myh11tm1Peri/Myh11+
Genetic Background: involves: 129 * C57BL/6

 MP:0000741 impaired contractility of detrusor smooth muscle "inability or reduced ability of the detrusor smooth muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Arfrp1tm2Asch/Arfrp1tm2Asch,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Arfrp1tm2Asch/Arfrp1tm2Asch,Tg(Vil1-cre)997Gum/?
Genetic Background: involves: C57BL/6 * SJL

 MP:0002328 abnormal airway resistance "anomaly in the opposition to flow of air caused by the forces of friction, measured as the ratio of driving pressure to the rate of air flow" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003026 decreased vascular smooth muscle contraction "reduced ability to constrict the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003290 hypoperistalsis "reduced intestinal movement characterized by waves of alternate circular contraction and relaxation of the muscular walls of the bowel that move bowel contents forward" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003352 increased circulating renin level "elevated blood concentration of this enzyme which is secreted by the kidney; it cleaves a bond in angiotensionogen to generate angiotensin I " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003566 abnormal cell adhesion "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0003622 incomplete emptying of bladder "upon urination, some urine is retained in the bladder instead of being excreted" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Myh11tm2Peri/Myh11tm2Peri
Genetic Background: involves: 129 * C57BL/6

 MP:0003624 anuria "inability to form or excrete urine" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004090 abnormal sarcomere morphology "any structural abnormality in the segment of a myofibril between two Z lines comprised of multi-protein complexes composed of three different filament systems; these systems work together to contract and relax muscle" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Myh11tm2Peri/Myh11tm2Peri
Genetic Background: involves: 129 * C57BL/6

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Krastm4Tyj/Kras+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0005620 abnormal muscle contractility "aberrant ability of a muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Myh11tm2Peri/Myh11tm2Peri
Genetic Background: involves: 129 * C57BL/6

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myh11tm2Peri/Myh11tm2Peri
Genetic Background: involves: 129 * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ppm1atm1.1Xya/Ppm1atm1.1Xya,Smad2tm1Xya/Smad2tm1Xya,Tg(KRT5-cre)1Xya/0
Genetic Background: involves: 129S6/SvEvTac * FVB/N

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Myh11tm2Peri/Myh11tm2Peri
Genetic Background: involves: 129 * C57BL/6

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012125 decreased bronchoconstrictive response "reduction in the expected bronchoconstrictive response to provocation challenge with lipopolysaccharide, bradykinin, histamine or other antigen/allergen or agent, often measured by plethysmography" [MGI:csmith]
Show

Allelic Composition: Myd88tm1Aki/Myd88tm1Aki
Genetic Background: B6.129P2-Myd88tm1Aki

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction
 ENSMUSG00000034868 Myl12b / Q3THE2 / Myosin regulatory light chain 12B / O14950* / myosin light chain 12B*  / complex
 ENSMUSG00000018830 Myh11 / myosin heavy chain 11 / P35749*  / complex
 ENSMUSG00000020900 Myh10 / Q61879 / Myosin-10 / P35580* / myosin heavy chain 10*  / complex
 ENSMUSG00000022443 Myh9 / Q8VDD5 / myosin, heavy polypeptide 9, non-muscle / P35579* / myosin heavy chain 9*  / complex
 ENSMUSG00000030739 Myh14 / Q6URW6 / Myosin-14 / Q7Z406* / myosin heavy chain 14*  / complex
 ENSMUSG00000090841 Myl6 / Q60605 / myosin, light polypeptide 6, alkali, smooth muscle and non-muscle / P60660* / myosin light chain 6*  / complex






 

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