ENSMUSG00000034868


Mus musculus

Features
Gene ID: ENSMUSG00000034868
  
Biological name :Myl12b
  
Synonyms : Myl12b / Myosin regulatory light chain 12B / Q3THE2
  
Possible biological names infered from orthology : myosin light chain 12B / O14950
  
Species: Mus musculus
  
Chr. number: 17
Strand: -1
Band: E1.3
Gene start: 70973920
Gene end: 70990787
  
Corresponding Affymetrix probe sets: 10452639 (MoGene1.0st)   1428608_at (Mouse Genome 430 2.0 Array)   1428609_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000042364
NCBI entrez gene - 67938     See in Manteia.
MGI - MGI:107494
RefSeq - NM_023402
RefSeq Peptide - NP_075891
swissprot - Q3THE2
Ensembl - ENSMUSG00000034868
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myl12.2ENSDARG00000025326Danio rerio
 ENSGALG00000038635Gallus gallus
 MYL12AENSGALG00000014854Gallus gallus
 MYL12BENSG00000118680Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Myl12aENSMUSG0000002404898
Myl9 / Q9CQ19 / Myosin regulatory light polypeptide 9 ENSMUSG0000006781894
Mylpf / P97457 / Mus musculus myosin light chain, phosphorylatable, fast skeletal muscle (Mylpf), transcript variant 2, mRNA. / Q96A32* / myosin light chain, phosphorylatable, fast skeletal muscle*ENSMUSG0000003067255
Myl2 / P51667 / Myosin regulatory light chain 2, ventricular/cardiac muscle isoform / P10916* / myosin light chain 2*ENSMUSG0000001393653
Myl10 / Q62082 / Myosin regulatory light chain 10 / Q9BUA6* / myosin light chain 10*ENSMUSG0000000547449
Myl7 / Q9QVP4 / Myosin regulatory light chain 2, atrial isoform / Q01449* / myosin light chain 7*ENSMUSG0000002046949


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR015070  DJBP, EF-hand domain
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008360 regulation of cell shape IMP
 cellular_componentGO:0001725 stress fiber IDA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0016460 myosin II complex IDA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0045177 apical part of cell IDA
 cellular_componentGO:0099738 cell cortex region IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0032036 myosin heavy chain binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Smooth Muscle Contraction
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000208 decreased hematocrit "less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0003019 increased circulating chloride level "elevated concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0005562 decreased mean corpuscular hemoglobin "less than the average levels of hemoglobin contained in an erythrocyte" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0005567 decreased circulating total protein level "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0005628 decreased circulating potassium level "less than the normal concentration in the blood of this alkaline metallic element, the most abundant intracellular ion; anomalies in the extracellular (circulating) concentration have important implications for the function of excitable tissues, such as nerve and muscle" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

 MP:0005633 increased circulating sodium level "greater than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Mta1tm1a(EUCOMM)Wtsi/Mta1tm1a(EUCOMM)Wtsi
Genetic Background: 129S/SvEvBrd-Mta1tm1a(EUCOMM)Wtsi/WtsiH

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000022781 Pak2 / Q8CIN4 / Serine/threonine-protein kinase PAK 2 PAK-2p27 PAK-2p34 / Q13177* / p21 (RAC1) activated kinase 2*  / reaction
 ENSMUSG00000034868 Myl12b / Q3THE2 / Myosin regulatory light chain 12B / O14950* / myosin light chain 12B*  / complex
 ENSMUSG00000022443 Myh9 / Q8VDD5 / myosin, heavy polypeptide 9, non-muscle / P35579* / myosin heavy chain 9*  / complex
 ENSMUSG00000030739 Myh14 / Q6URW6 / Myosin-14 / Q7Z406* / myosin heavy chain 14*  / complex
 ENSMUSG00000018830 Myh11 / myosin heavy chain 11 / P35749*  / complex
 ENSMUSG00000020900 Myh10 / Q61879 / Myosin-10 / P35580* / myosin heavy chain 10*  / complex
 ENSMUSG00000090841 Myl6 / Q60605 / myosin, light polypeptide 6, alkali, smooth muscle and non-muscle / P60660* / myosin light chain 6*  / complex






 

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