| MP:0000269 | abnormal looping morphogenesis | "atypical bending of the primitive heart tube during early development" [J:27443] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0000270 | abnormal heart tube morphology | "malformed embryonic heart " [J:37888] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0000278 | abnormal myocardial fiber morphology | "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0000295 | poorly developed ventricular trabeculae | "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0000297 | abnormal endocardial cushion morphology | "malformation of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal; these mounds eventually fuse to form the valves between the right and left atrioventricular orifices" [Stedman s Medical Dictionary:ISBN 0-683-40008-8] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0001622 | abnormal vasculogenesis | "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0001629 | abnormal heart rate | "greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0001636 | irregular heartbeat | "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038] |
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Allelic Composition: Hcn2tm1Ldw/Hcn2tm1Ldw
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0001718 | abnormal yolk sac | "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0001719 | absent vitelline blood vessels | "missing vasculature of the yolk sac" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62571, J:12623] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0001730 | embryonic growth arrest | "the cessation of development beyond a particular stage" [J:17509] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0001787 | pericardial edema | "accumulation of watery fluid in the pericardial sac of the heart" [J:52597] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0002753 | dilated left ventricle | "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0002972 | abnormal cardiac muscle contractility | "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Myl7tm1(cre)Krc/Myl7+,Prkg1tm2Naw/Prkg1tm2Naw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)
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| MP:0003567 | abnormal cardiomyocyte proliferation | "anomalous division or replication of cardiac muscle cells" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Mapk10tm1Flv/Mapk10tm1Flv,Mapk9tm1Flv/Mapk9tm1Flv
Genetic Background: B6.129S-Mapk9tm1Flv Mapk10tm1Flv
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| MP:0003984 | embryonic growth retardation | "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0004076 | abnormal vitelline vascular remodelling | "anomaly in the conversion of the primary (honeycomb-like) vascular plexus of the yolk sac into a mature vascular network" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0006126 | abnormal outflow tract development | "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0006142 | abnormal sinoatrial node conduction | "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Hcn2tm1Ldw/Hcn2tm2Ldw,Myl7tm1(cre)Krc/Myl7+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
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| MP:0008725 | enlarged heart atrium | "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0008825 | abnormal cardiac epithelial to mesenchymal transition | "anomaly in the process by which endocardial cells of the atrioventricular canal lose their epithelial characteristics, delaminante from the endocardial sheet, become migratory and invade the cardiac jelly, and develop mesenchymal characteristics eventaully forming the endocardial cushions reqired for septum and atrioventricular valve formation" [PMID:17303760] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0010502 | ventricle myocardium hypoplasia | "underdevelopment or reduced size, usually due to a reduced number of cells, of the ventricular part of the heart myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0011098 | complete embryonic lethality during organogenesis | "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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| MP:0012253 | abnormal intersomitic vessel morphology | "any structural anomaly of the primary blood vessel sprouts that originate from the dorsal aorta and posterior cardinal vein and align dorsoventrally at the myotomal boundaries between somites" [MGI:anna] |
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Allelic Composition: Ppargtm1Auw/Ppargtm1Auw
Genetic Background: either: 129/Sv or C57BL/6J or (involves: 129/Sv * C57BL/6J)
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