ENSG00000118680


Homo sapiens

Features
Gene ID: ENSG00000118680
  
Biological name :MYL12B
  
Synonyms : MYL12B / myosin light chain 12B / O14950
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 18
Strand: 1
Band: p11.31
Gene start: 3261909
Gene end: 3278284
  
Corresponding Affymetrix probe sets: 201318_s_at (Human Genome U133 Plus 2.0 Array)   221474_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000237500
Ensembl peptide - ENSP00000383037
Ensembl peptide - ENSP00000463559
Ensembl peptide - ENSP00000464464
NCBI entrez gene - 103910     See in Manteia.
OMIM - 609211
RefSeq - NM_001144944
RefSeq - NM_001144945
RefSeq - NM_033546
RefSeq Peptide - NP_001138416
RefSeq Peptide - NP_001138417
RefSeq Peptide - NP_291024
swissprot - O14950
Ensembl - ENSG00000118680
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 myl12.2ENSDARG00000025326Danio rerio
 ENSGALG00000038635Gallus gallus
 MYL12AENSGALG00000014854Gallus gallus
 Myl12bENSMUSG00000034868Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYL12A / P19105 / myosin light chain 12AENSG0000010160898
MYL2 / P10916 / myosin light chain 2ENSG0000011124555
MYLPF / Q96A32 / myosin light chain, phosphorylatable, fast skeletal muscleENSG0000018020954
MYL5 / Q02045 / myosin light chain 5ENSG0000021537554
MYL10 / Q9BUA6 / myosin light chain 10ENSG0000010643652
MYL7 / Q01449 / myosin light chain 7ENSG0000010663149


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR011992  EF-hand domain pair
 IPR015070  DJBP, EF-hand domain
 IPR018247  EF-Hand 1, calcium-binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006936 muscle contraction TAS
 biological_processGO:0008360 regulation of cell shape IEA
 cellular_componentGO:0001725 stress fiber IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005903 brush border IEA
 cellular_componentGO:0016459 myosin complex IEA
 cellular_componentGO:0016460 myosin II complex IEA
 cellular_componentGO:0030018 Z disc IEA
 cellular_componentGO:0045177 apical part of cell IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0099738 cell cortex region IDA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0032036 myosin heavy chain binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
EPHA-mediated growth cone collapse
Sema4D induced cell migration and growth-cone collapse
Smooth Muscle Contraction
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000092841 MYL6 / P60660 / myosin light chain 6  / complex
 ENSG00000100345 MYH9 / P35579 / myosin heavy chain 9  / complex
 ENSG00000105357 MYH14 / Q7Z406 / myosin heavy chain 14  / complex
 ENSG00000133392 MYH11 / P35749 / myosin heavy chain 11  / complex
 ENSG00000118680 MYL12B / O14950 / myosin light chain 12B  / complex
 ENSG00000133026 MYH10 / P35580 / myosin heavy chain 10  / complex
 ENSG00000058272 O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12A  / reaction
 ENSG00000122966 CIT / O14578 / citron rho-interacting serine/threonine kinase  / reaction
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000134318 ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2  / reaction
 ENSG00000077157 O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12B  / reaction
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / reaction
 ENSG00000101335 MYL9 / P24844 / myosin light chain 9  / complex
 ENSG00000213639 P62140 / PPP1CB / protein phosphatase 1 catalytic subunit beta  / reaction
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / reaction
 ENSG00000180370 PAK2 / Q13177 / p21 (RAC1) activated kinase 2  / reaction
 ENSG00000065534 MYLK / Q15746 / myosin light chain kinase  / reaction
 ENSG00000198668 CALM1 / P0DP23 / calmodulin 1  / reaction
 ENSG00000067900 ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1  / reaction






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr