ENSG00000077157


Homo sapiens

Features
Gene ID: ENSG00000077157
  
Biological name :PPP1R12B
  
Synonyms : O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12B
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q32.1
Gene start: 202348699
Gene end: 202592706
  
Corresponding Affymetrix probe sets: 1555444_a_at (Human Genome U133 Plus 2.0 Array)   1557553_at (Human Genome U133 Plus 2.0 Array)   201957_at (Human Genome U133 Plus 2.0 Array)   201958_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000480852
Ensembl peptide - ENSP00000476755
Ensembl peptide - ENSP00000484005
Ensembl peptide - ENSP00000489098
Ensembl peptide - ENSP00000489025
Ensembl peptide - ENSP00000488930
Ensembl peptide - ENSP00000349206
Ensembl peptide - ENSP00000375821
Ensembl peptide - ENSP00000417159
Ensembl peptide - ENSP00000417814
Ensembl peptide - ENSP00000417975
NCBI entrez gene - 4660     See in Manteia.
OMIM - 603768
RefSeq - XM_017001355
RefSeq - XM_005245206
RefSeq - XM_017001342
RefSeq - XM_017001343
RefSeq - XM_017001344
RefSeq - XM_017001345
RefSeq - XM_017001346
RefSeq - XM_017001347
RefSeq - XM_017001348
RefSeq - XM_017001349
RefSeq - XM_017001350
RefSeq - XM_017001351
RefSeq - XM_017001352
RefSeq - XM_017001353
RefSeq - XM_017001354
RefSeq - NM_001167857
RefSeq - NM_001167858
RefSeq - NM_001197131
RefSeq - NM_002481
RefSeq - NM_032103
RefSeq - NM_032104
RefSeq Peptide - NP_002472
RefSeq Peptide - NP_115286
RefSeq Peptide - NP_115287
RefSeq Peptide - NP_001161329
RefSeq Peptide - NP_001161330
RefSeq Peptide - NP_001184060
RefSeq Peptide - NP_001317958
swissprot - O60237
swissprot - A0A0U1RQP2
swissprot - A0A0U1RQI8
swissprot - H7C4R6
swissprot - E1CKY7
swissprot - Q6GQY8
swissprot - A0A0A0MS24
Ensembl - ENSG00000077157
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX323087.1ENSDARG00000117155Danio rerio
 Q8BG95ENSMUSG00000073557Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12AENSG0000005827250
Q9BZL4 / PPP1R12C / protein phosphatase 1 regulatory subunit 12CENSG0000012550331
Q96I34 / PPP1R16A / protein phosphatase 1 regulatory subunit 16AENSG0000016097215
Q96T49 / PPP1R16B / protein phosphatase 1 regulatory subunit 16BENSG0000010144515
Q13625 / TP53BP2 / tumor protein p53 binding protein 2ENSG0000014351413
Q96KQ4 / PPP1R13B / protein phosphatase 1 regulatory subunit 13BENSG0000008880813
Q8WUF5 / PPP1R13L / protein phosphatase 1 regulatory subunit 13 likeENSG000001048818
Q86WC6 / PPP1R27 / protein phosphatase 1 regulatory subunit 27ENSG000001826765
NRARP / Q7Z6K4 / NOTCH regulated ankyrin repeat proteinENSG000001984353


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR017401  Protein phosphatase 1 regulatory subunit 12A/B/C
 IPR020683  Ankyrin repeat-containing domain
 IPR031775  cGMP-dependent protein kinase, interacting domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle TAS
 biological_processGO:0006937 regulation of muscle contraction TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0043085 positive regulation of catalytic activity IEA
 biological_processGO:0050790 regulation of catalytic activity IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0030018 Z disc ISS
 cellular_componentGO:0031672 A band ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity TAS
 molecular_functionGO:0019208 phosphatase regulator activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
RHO GTPases activate PKNs
RHO GTPases activate CIT
RHO GTPases Activate ROCKs
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000058272 O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12A  / complex
 ENSG00000067560 RHOA / P61586 / ras homolog family member A  / reaction
 ENSG00000134318 ROCK2 / O75116 / Rho associated coiled-coil containing protein kinase 2  / reaction
 ENSG00000133026 MYH10 / P35580 / myosin heavy chain 10  / reaction
 ENSG00000101335 MYL9 / P24844 / myosin light chain 9  / reaction
 ENSG00000166851 PLK1 / P53350 / polo like kinase 1  / reaction
 ENSG00000118680 MYL12B / O14950 / myosin light chain 12B  / reaction
 ENSG00000105357 MYH14 / Q7Z406 / myosin heavy chain 14  / reaction
 ENSG00000100345 MYH9 / P35579 / myosin heavy chain 9  / reaction
 ENSG00000092841 MYL6 / P60660 / myosin light chain 6  / reaction
 ENSG00000213639 P62140 / PPP1CB / protein phosphatase 1 catalytic subunit beta  / complex
 ENSG00000133392 MYH11 / P35749 / myosin heavy chain 11  / reaction
 ENSG00000143878 RHOB / P62745 / ras homolog family member B  / reaction
 ENSG00000149269 PAK1 / Q13153 / p21 (RAC1) activated kinase 1  / reaction
 ENSG00000167641 Q96A00 / PPP1R14A / protein phosphatase 1 regulatory inhibitor subunit 14A  / complex / reaction
 ENSG00000155366 RHOC / P08134 / ras homolog family member C  / reaction
 ENSG00000067900 ROCK1 / Q13464 / Rho associated coiled-coil containing protein kinase 1  / reaction






 

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