ENSMUSG00000073557


Mus musculus

Features
Gene ID: ENSMUSG00000073557
  
Biological name :Ppp1r12b
  
Synonyms : Ppp1r12b / protein phosphatase 1, regulatory (inhibitor) subunit 12B / Q8BG95
  
Possible biological names infered from orthology : O60237 / protein phosphatase 1 regulatory subunit 12B
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: E4
Gene start: 134754658
Gene end: 134955942
  
Corresponding Affymetrix probe sets: 10357932 (MoGene1.0st)   10357944 (MoGene1.0st)   10357946 (MoGene1.0st)   10357948 (MoGene1.0st)   10357950 (MoGene1.0st)   10357952 (MoGene1.0st)   10357954 (MoGene1.0st)   1431462_at (Mouse Genome 430 2.0 Array)   1434786_at (Mouse Genome 430 2.0 Array)   1445850_at (Mouse Genome 430 2.0 Array)   1460091_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047463
Ensembl peptide - ENSMUSP00000083633
Ensembl peptide - ENSMUSP00000107788
Ensembl peptide - ENSMUSP00000131406
NCBI entrez gene - 329251     See in Manteia.
MGI - MGI:1916417
RefSeq - XM_017321279
RefSeq - NM_001081307
RefSeq - XM_006529710
RefSeq - XM_017321277
RefSeq - XM_017321278
RefSeq - XM_006529707
RefSeq - XM_006529709
RefSeq Peptide - NP_001074776
swissprot - Q8BG95
swissprot - A6H644
Ensembl - ENSMUSG00000073557
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 BX323087.1ENSDARG00000117155Danio rerio
 O60237ENSG00000077157Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9DBR7 / Ppp1r12a / protein phosphatase 1, regulatory (inhibitor) subunit 12A / O14974* / protein phosphatase 1 regulatory subunit 12A*ENSMUSG0000001990746
Q3UMT1 / Ppp1r12c / Protein phosphatase 1 regulatory subunit 12C / Q9BZL4*ENSMUSG0000001925431
Q923M0 / Ppp1r16a / protein phosphatase 1, regulatory (inhibitor) subunit 16A / Q96I34* / protein phosphatase 1 regulatory subunit 16A*ENSMUSG0000003381916
Q8VHQ3 / Ppp1r16b / protein phosphatase 1, regulatory (inhibitor) subunit 16B / Q96T49* / protein phosphatase 1 regulatory subunit 16B*ENSMUSG0000003775416
Trp53bp2 / transformation related protein 53 binding protein 2 / Q13625* / TP53BP2* / tumor protein p53 binding protein 2*ENSMUSG0000002651013
Q62415 / Ppp1r13b / protein phosphatase 1, regulatory (inhibitor) subunit 13B / Q96KQ4* / protein phosphatase 1 regulatory subunit 13B*ENSMUSG0000002128512
Q5I1X5 / Ppp1r13l / protein phosphatase 1, regulatory (inhibitor) subunit 13 like / Q8WUF5* / protein phosphatase 1 regulatory subunit 13 like*ENSMUSG000000407348
Q9D119 / Ppp1r27 / Protein phosphatase 1 regulatory subunit 27 / Q86WC6*ENSMUSG000000251296
Nrarp / Q91ZA8 / Notch-regulated ankyrin repeat-containing protein / Q7Z6K4* / NOTCH regulated ankyrin repeat protein*ENSMUSG000000782023


Protein motifs (from Interpro)
Interpro ID Name
 IPR002110  Ankyrin repeat
 IPR017401  Protein phosphatase 1 regulatory subunit 12A/B/C
 IPR020683  Ankyrin repeat-containing domain
 IPR031775  cGMP-dependent protein kinase, interacting domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008150 biological_process ND
 biological_processGO:0050790 regulation of catalytic activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0031672 A band IDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019208 phosphatase regulator activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA


Pathways (from Reactome)
Pathway description
Regulation of PLK1 Activity at G2/M Transition
RHO GTPases activate PKNs
RHO GTPases activate PAKs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030774 Pak1 / Mus musculus p21 protein (Cdc42/Rac)-activated kinase 1 (Pak1), transcript variant 3, mRNA. / Q13153* / p21 (RAC1) activated kinase 1*  / reaction
 ENSMUSG00000037166 Q91VC7 / Ppp1r14a / Protein phosphatase 1 regulatory subunit 14A / Q96A00* / protein phosphatase 1 regulatory inhibitor subunit 14A*  / complex / reaction
 ENSMUSG00000014956 P62141 / Ppp1cb / Serine/threonine-protein phosphatase PP1-beta catalytic subunit / P62140* / protein phosphatase 1 catalytic subunit beta*  / complex
 ENSMUSG00000019907 Q9DBR7 / Ppp1r12a / protein phosphatase 1, regulatory (inhibitor) subunit 12A / O14974* / protein phosphatase 1 regulatory subunit 12A*  / complex
 ENSMUSG00000030867 Plk1 / Q07832 / polo like kinase 1 / P53350*  / reaction






 

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