ENSMUSG00000021285


Mus musculus

Features
Gene ID: ENSMUSG00000021285
  
Biological name :Ppp1r13b
  
Synonyms : Ppp1r13b / protein phosphatase 1, regulatory (inhibitor) subunit 13B / Q62415
  
Possible biological names infered from orthology : protein phosphatase 1 regulatory subunit 13B / Q96KQ4
  
Species: Mus musculus
  
Chr. number: 12
Strand: -1
Band: F1
Gene start: 111828457
Gene end: 111908110
  
Corresponding Affymetrix probe sets: 10402730 (MoGene1.0st)   1434895_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000062464
Ensembl peptide - ENSMUSP00000152424
NCBI entrez gene - 21981     See in Manteia.
MGI - MGI:1336199
RefSeq - XM_006515797
RefSeq - NM_011625
RefSeq - XM_006515796
RefSeq Peptide - NP_035755
swissprot - Q62415
swissprot - A0A1Y7VJH3
Ensembl - ENSMUSG00000021285
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1r13baENSDARG00000004377Danio rerio
 ppp1r13bbENSDARG00000009142Danio rerio
 PPP1R13BENSGALG00000011548Gallus gallus
 Q96KQ4ENSG00000088808Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trp53bp2 / transformation related protein 53 binding protein 2 / Q13625* / TP53BP2* / tumor protein p53 binding protein 2*ENSMUSG0000002651049
Q5I1X5 / Ppp1r13l / protein phosphatase 1, regulatory (inhibitor) subunit 13 like / Q8WUF5* / protein phosphatase 1 regulatory subunit 13 like*ENSMUSG0000004073422
Q8BG95 / Ppp1r12b / protein phosphatase 1, regulatory (inhibitor) subunit 12B / O60237* / protein phosphatase 1 regulatory subunit 12B*ENSMUSG0000007355711
Q9DBR7 / Ppp1r12a / protein phosphatase 1, regulatory (inhibitor) subunit 12A / O14974* / protein phosphatase 1 regulatory subunit 12A*ENSMUSG0000001990710
Q3UMT1 / Ppp1r12c / Protein phosphatase 1 regulatory subunit 12C / Q9BZL4*ENSMUSG000000192549
Q923M0 / Ppp1r16a / protein phosphatase 1, regulatory (inhibitor) subunit 16A / Q96I34* / protein phosphatase 1 regulatory subunit 16A*ENSMUSG000000338198
Q8VHQ3 / Ppp1r16b / protein phosphatase 1, regulatory (inhibitor) subunit 16B / Q96T49* / protein phosphatase 1 regulatory subunit 16B*ENSMUSG000000377547
Q9D119 / Ppp1r27 / Protein phosphatase 1 regulatory subunit 27 / Q86WC6*ENSMUSG000000251293
Nrarp / Q91ZA8 / Notch-regulated ankyrin repeat-containing protein / Q7Z6K4* / NOTCH regulated ankyrin repeat protein*ENSMUSG000000782021


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR028319  Apoptosis-stimulating of p53 protein 1
 IPR029071  Ubiquitin-like domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Association with Co-factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001786 skin edema "accumulation of an excessive amount of fluid in the skin" [J:65039]
Show

Allelic Composition: Myo5argsc450/Myo5argsc450
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0001879 abnormal lymphatic vessel morphology "malformation of the network of vessels which carries lymph around the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo5argsc450/Myo5argsc450
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

Allelic Composition: Ppp1r13btm1Suda/Ppp1r13btm1Suda,Trp53tm1Sia/Trp53tm1Sia
Genetic Background: involves: various

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msr1tm1Csk/Msr1tm1Csk
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003659 abnormal lymph circulation "abnormalities in the flow of the lymph from the tissues into the veins of the circulatory system" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:95885]
Show

Allelic Composition: Myo5argsc450/Myo5argsc450
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myo5argsc450/Myo5argsc450
Genetic Background: involves: C57BL/6JJcl * DBA/2JJcl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / complex / reaction
 ENSMUSG00000022510 Trp63 / O88898 / transformation related protein 63 / TP63* / Q9H3D4* / tumor protein p63*  / complex / reaction
 ENSMUSG00000029026 Trp73 / Q9JJP2 / transformation related protein 73 / TP73* / O15350* / tumor protein p73*  / complex / reaction






 

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