ENSG00000088808


Homo sapiens

Features
Gene ID: ENSG00000088808
  
Biological name :PPP1R13B
  
Synonyms : PPP1R13B / protein phosphatase 1 regulatory subunit 13B / Q96KQ4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: -1
Band: q32.33
Gene start: 103733752
Gene end: 103847590
  
Corresponding Affymetrix probe sets: 216347_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000452376
Ensembl peptide - ENSP00000451433
Ensembl peptide - ENSP00000451739
Ensembl peptide - ENSP00000202556
Ensembl peptide - ENSP00000450734
Ensembl peptide - ENSP00000451396
NCBI entrez gene - 23368     See in Manteia.
OMIM - 606455
RefSeq - XM_017021118
RefSeq - NM_015316
RefSeq - XM_005267487
RefSeq - XM_011536593
RefSeq - XM_017021116
RefSeq - XM_017021117
RefSeq Peptide - NP_056131
swissprot - Q96KQ4
swissprot - G3V3S2
swissprot - G3V5J1
swissprot - H0YJG1
swissprot - H0YJL1
swissprot - G3V2L3
Ensembl - ENSG00000088808
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ppp1r13baENSDARG00000004377Danio rerio
 ppp1r13bbENSDARG00000009142Danio rerio
 PPP1R13BENSGALG00000011548Gallus gallus
 Q62415ENSMUSG00000021285Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q13625 / TP53BP2 / tumor protein p53 binding protein 2ENSG0000014351450
Q8WUF5 / PPP1R13L / protein phosphatase 1 regulatory subunit 13 likeENSG0000010488123
O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12AENSG0000005827212
O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12BENSG0000007715712
Q9BZL4 / PPP1R12C / protein phosphatase 1 regulatory subunit 12CENSG0000012550310
Q96I34 / PPP1R16A / protein phosphatase 1 regulatory subunit 16AENSG000001609728
Q96T49 / PPP1R16B / protein phosphatase 1 regulatory subunit 16BENSG000001014457
Q86WC6 / PPP1R27 / protein phosphatase 1 regulatory subunit 27ENSG000001826762
NRARP / Q7Z6K4 / NOTCH regulated ankyrin repeat proteinENSG000001984351


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR028319  Apoptosis-stimulating of p53 protein 1
 IPR029071  Ubiquitin-like domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0045786 negative regulation of cell cycle IEA
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IDA
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA


Pathways (from Reactome)
Pathway description
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000078900 TP73 / O15350 / tumor protein p73  / complex / reaction
 ENSG00000073282 TP63 / Q9H3D4 / tumor protein p63  / reaction / complex
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex






 

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