ENSG00000143514


Homo sapiens

Features
Gene ID: ENSG00000143514
  
Biological name :TP53BP2
  
Synonyms : Q13625 / TP53BP2 / tumor protein p53 binding protein 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q41
Gene start: 223779899
Gene end: 223845972
  
Corresponding Affymetrix probe sets: 203120_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000420225
Ensembl peptide - ENSP00000417987
Ensembl peptide - ENSP00000418252
Ensembl peptide - ENSP00000341957
Ensembl peptide - ENSP00000375750
Ensembl peptide - ENSP00000417174
NCBI entrez gene - 7159     See in Manteia.
OMIM - 602143
RefSeq - XM_017002220
RefSeq - NM_001031685
RefSeq - NM_005426
RefSeq - XM_011544268
RefSeq - XM_011544269
RefSeq Peptide - NP_001026855
RefSeq Peptide - NP_005417
swissprot - H0Y847
swissprot - H7C5L8
swissprot - Q13625
swissprot - F8WBY9
Ensembl - ENSG00000143514
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tp53bp2aENSDARG00000009136Danio rerio
 tp53bp2bENSDARG00000054858Danio rerio
 TP53BP2ENSGALG00000042816Gallus gallus
 Trp53bp2ENSMUSG00000026510Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q96KQ4 / PPP1R13B / protein phosphatase 1 regulatory subunit 13BENSG0000008880848
Q8WUF5 / PPP1R13L / protein phosphatase 1 regulatory subunit 13 likeENSG0000010488123
O14974 / PPP1R12A / protein phosphatase 1 regulatory subunit 12AENSG0000005827212
O60237 / PPP1R12B / protein phosphatase 1 regulatory subunit 12BENSG0000007715712
Q9BZL4 / PPP1R12C / protein phosphatase 1 regulatory subunit 12CENSG0000012550311
Q96T49 / PPP1R16B / protein phosphatase 1 regulatory subunit 16BENSG000001014457
Q96I34 / PPP1R16A / protein phosphatase 1 regulatory subunit 16AENSG000001609727
Q86WC6 / PPP1R27 / protein phosphatase 1 regulatory subunit 27ENSG000001826763
NRARP / Q7Z6K4 / NOTCH regulated ankyrin repeat proteinENSG000001984351


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR002110  Ankyrin repeat
 IPR011989  Armadillo-like helical
 IPR020683  Ankyrin repeat-containing domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0042981 regulation of apoptotic process TAS
 biological_processGO:0045786 negative regulation of cell cycle TAS
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IDA
 biological_processGO:1900119 positive regulation of execution phase of apoptosis IMP
 biological_processGO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
 biological_processGO:1901216 positive regulation of neuron death IEA
 biological_processGO:1901796 regulation of signal transduction by p53 class mediator TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0002039 p53 binding IPI
 molecular_functionGO:0005070 SH3/SH2 adaptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017124 SH3 domain binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0051059 NF-kappaB binding IPI


Pathways (from Reactome)
Pathway description
Activation of PUMA and translocation to mitochondria
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000078900 TP73 / O15350 / tumor protein p73  / complex / reaction
 ENSG00000073282 TP63 / Q9H3D4 / tumor protein p63  / reaction / complex
 ENSG00000141510 TP53 / P04637 / tumor protein p53  / reaction / complex






 

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