ENSMUSG00000026510


Mus musculus

Features
Gene ID: ENSMUSG00000026510
  
Biological name :Trp53bp2
  
Synonyms : transformation related protein 53 binding protein 2 / Trp53bp2
  
Possible biological names infered from orthology : Q13625 / TP53BP2 / tumor protein p53 binding protein 2
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: H5
Gene start: 182409172
Gene end: 182462432
  
Corresponding Affymetrix probe sets: 10352396 (MoGene1.0st)   1433937_at (Mouse Genome 430 2.0 Array)   1433938_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112508
Ensembl peptide - ENSMUSP00000141889
NCBI entrez gene - 209456     See in Manteia.
MGI - MGI:2138319
RefSeq - NM_173378
RefSeq Peptide - NP_775554
swissprot - E9QJU8
swissprot - A0A0A6YX89
Ensembl - ENSMUSG00000026510
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tp53bp2aENSDARG00000009136Danio rerio
 tp53bp2bENSDARG00000054858Danio rerio
 TP53BP2ENSGALG00000042816Gallus gallus
 Q13625ENSG00000143514Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q62415 / Ppp1r13b / protein phosphatase 1, regulatory (inhibitor) subunit 13B / Q96KQ4* / protein phosphatase 1 regulatory subunit 13B*ENSMUSG0000002128547
Q5I1X5 / Ppp1r13l / protein phosphatase 1, regulatory (inhibitor) subunit 13 like / Q8WUF5* / protein phosphatase 1 regulatory subunit 13 like*ENSMUSG0000004073422
Q8BG95 / Ppp1r12b / protein phosphatase 1, regulatory (inhibitor) subunit 12B / O60237* / protein phosphatase 1 regulatory subunit 12B*ENSMUSG0000007355711
Q9DBR7 / Ppp1r12a / protein phosphatase 1, regulatory (inhibitor) subunit 12A / O14974* / protein phosphatase 1 regulatory subunit 12A*ENSMUSG0000001990711
Q3UMT1 / Ppp1r12c / Protein phosphatase 1 regulatory subunit 12C / Q9BZL4*ENSMUSG0000001925410
Q8VHQ3 / Ppp1r16b / protein phosphatase 1, regulatory (inhibitor) subunit 16B / Q96T49* / protein phosphatase 1 regulatory subunit 16B*ENSMUSG000000377547
Q923M0 / Ppp1r16a / protein phosphatase 1, regulatory (inhibitor) subunit 16A / Q96I34* / protein phosphatase 1 regulatory subunit 16A*ENSMUSG000000338196
Q9D119 / Ppp1r27 / Protein phosphatase 1 regulatory subunit 27 / Q86WC6*ENSMUSG000000251293
Nrarp / Q91ZA8 / Notch-regulated ankyrin repeat-containing protein / Q7Z6K4* / NOTCH regulated ankyrin repeat protein*ENSMUSG000000782021


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR002110  Ankyrin repeat
 IPR020683  Ankyrin repeat-containing domain
 IPR029071  Ubiquitin-like domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator IEA
 biological_processGO:1900119 positive regulation of execution phase of apoptosis IEA
 biological_processGO:1901216 positive regulation of neuron death IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0002039 p53 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051059 NF-kappaB binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Association with Co-factors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000440 domed skull 
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu

 MP:0000790 abnormal stratification in cerebral cortex "abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu

 MP:0001328 disorganized retinal layers "delaminated or mispositioned sheets of cells comprising the optic part of the retina" [J:33400]
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Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

Allelic Composition: Trp53bp2tm1Cdlo/Trp53bp2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Trp53tm1Brd/Trp53+,Trp53bp2tm1Cdlo/Trp53bp2+
Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trp53bp2tm1Cdlo/Trp53bp2+,Tg(EmuSR-tTa)83Bop/0,Tg(tetO-MYC)36aBop/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0002036 rhabdomyosarcoma "malignant tumor derived from skeletal (striated) muscle" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Trp53bp2tm1Cdlo/Trp53bp2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003728 abnormal photoreceptor layer "malformation/anomalous structure of the photoreceptor layer" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003731 abnormal outer nuclear layer morphology "malformation/anomalous structure of the retinal layer that contains the nuclei and cell bodies of rods and cones" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004045 abnormal cell cycle checkpoint function "anomaly in the amount of time spent at the points in the cell cycle (end of G1 phase, end of G2 phase, and during metaphase) which prevent the cell from progressing to the next phase when conditions are unfavorable" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53bp2tm1Cdlo/Trp53bp2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu

 MP:0004274 abnormal embryonic/fetal subventricular zone morphology "any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu

 MP:0004500 increased incidence of ionizing radiation-induced tumors "higher than normal frequency of tumor incidence induced by radiation in which the individual particle or photon carries sufficient energy to completely remove an electron from its orbit; common types of this radiation include gamma-rays and X-rays" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trp53bp2tm1Cdlo/Trp53bp2+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004948 abnormal neuronal precursor proliferation "any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004980 increased neuronal precursor cell number "increased number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0006009 abnormal neuronal migration "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu

 MP:0006071 abnormal retinal progenitor morphology "anomoly in the proliferation or differentiation of the cells that give rise to the various cells of the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92622:]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008439 abnormal cortical plate morphology "any strucutral anomaly of the outer neural tube region in which post-mitotic neuroblasts migrate along radial glia to form the adult cortical layers" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:1812236]
Show

Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu

 MP:0008458 abnormal cortical ventricular zone morphology "any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu

 MP:0009937 abnormal neuron differentiation "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Hps6ru-8J/Hps6ru-8J
Genetic Background: B6(CB17)-Hps6ru-8J/J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Tmem100tm1e.1(KOMP)Wtsi/Tmem100tm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem100tm1e.1(KOMP)Wtsi/Tcp

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp53bp2tm1Xlu/Trp53bp2+
Genetic Background: involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6J

 MP:0012676 dilated brain ventricles "the luminal space of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord is increased in volume or area, usually with an increase in contained fluid" [MGI:anna]
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Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012704 abnormal embryonic neuroepithelial cell proliferation "any anomaly in the ability of the cells of the embryonic neuroepithelium to undergo expansion by cell division" [CL:0000710, MGI:anna]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Trp53bp2tm1Xlu/Trp53bp2tm1Xlu
Genetic Background: C.129S6-Trp53bp2tm1Xlu

 MP:0012705 increased embryonic neuroepithelial cell proliferation "increase in the expansion rate of the cells of the embryonic neuroepithelium by cell division" [CL:0000710, MGI:anna]
Show

Allelic Composition: Akt2tm1.1Mbb/Akt2tm1.1Mbb
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Tmem100tm1e.1(KOMP)Wtsi/Tmem100tm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem100tm1e.1(KOMP)Wtsi/Tcp

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Tmem100tm1e.1(KOMP)Wtsi/Tmem100tm1e.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem100tm1e.1(KOMP)Wtsi/Tcp

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000059552 Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*  / complex / reaction
 ENSMUSG00000022510 Trp63 / O88898 / transformation related protein 63 / TP63* / Q9H3D4* / tumor protein p63*  / complex / reaction
 ENSMUSG00000029026 Trp73 / Q9JJP2 / transformation related protein 73 / TP73* / O15350* / tumor protein p73*  / complex / reaction






 

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