Manteia - Molecule gene

ENSMUSG00000040734

Mus musculus

Features

Gene ID:	ENSMUSG00000040734

Biological name :	Ppp1r13l

Synonyms :	Ppp1r13l / protein phosphatase 1, regulatory (inhibitor) subunit 13 like / Q5I1X5

Possible biological names infered from orthology :	protein phosphatase 1 regulatory subunit 13 like / Q8WUF5

Species:	Mus musculus

Chr. number:	7
Strand:	1
Band:	A3
Gene start:	19359749
Gene end:	19378533

Corresponding Affymetrix probe sets:	10550660 (MoGene1.0st) 1439530_a_at (Mouse Genome 430 2.0 Array) 1456774_at (Mouse Genome 430 2.0 Array) 1459592_a_at (Mouse Genome 430 2.0 Array) 1459593_x_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000114443 Ensembl peptide - ENSMUSP00000118309 Ensembl peptide - ENSMUSP00000116351 Ensembl peptide - ENSMUSP00000047839 NCBI entrez gene - 333654 See in Manteia. MGI - MGI:3525053 RefSeq - XM_006540126 RefSeq - XM_006540127 RefSeq - XM_006540128 RefSeq - XM_006540129 RefSeq - NM_001010836 RefSeq Peptide - NP_001010836 swissprot - Q3TCU2 swissprot - D3YXE7 swissprot - D3YVH2 swissprot - D3Z5Q5 swissprot - Q5I1X5 Ensembl - ENSMUSG00000040734

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
ppp1r13l	ENSDARG00000013777	Danio rerio
Q8WUF5	ENSG00000104881	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Trp53bp2 / transformation related protein 53 binding protein 2 / Q13625* / TP53BP2* / tumor protein p53 binding protein 2*	ENSMUSG00000026510	31
Q62415 / Ppp1r13b / protein phosphatase 1, regulatory (inhibitor) subunit 13B / Q96KQ4* / protein phosphatase 1 regulatory subunit 13B*	ENSMUSG00000021285	29
Q8BG95 / Ppp1r12b / protein phosphatase 1, regulatory (inhibitor) subunit 12B / O60237* / protein phosphatase 1 regulatory subunit 12B*	ENSMUSG00000073557	9
Q3UMT1 / Ppp1r12c / Protein phosphatase 1 regulatory subunit 12C / Q9BZL4*	ENSMUSG00000019254	9
Q9DBR7 / Ppp1r12a / protein phosphatase 1, regulatory (inhibitor) subunit 12A / O14974* / protein phosphatase 1 regulatory subunit 12A*	ENSMUSG00000019907	8
Q923M0 / Ppp1r16a / protein phosphatase 1, regulatory (inhibitor) subunit 16A / Q96I34* / protein phosphatase 1 regulatory subunit 16A*	ENSMUSG00000033819	5
Q8VHQ3 / Ppp1r16b / protein phosphatase 1, regulatory (inhibitor) subunit 16B / Q96T49* / protein phosphatase 1 regulatory subunit 16B*	ENSMUSG00000037754	4
Q9D119 / Ppp1r27 / Protein phosphatase 1 regulatory subunit 27 / Q86WC6*	ENSMUSG00000025129	1
Nrarp / Q91ZA8 / Notch-regulated ankyrin repeat-containing protein / Q7Z6K4* / NOTCH regulated ankyrin repeat protein*	ENSMUSG00000078202	1

Protein motifs (from Interpro)

Interpro ID	Name
IPR001452	SH3 domain
IPR002110	Ankyrin repeat
IPR020683	Ankyrin repeat-containing domain
IPR028320	RelA-associated inhibitor
IPR036028	SH3-like domain superfamily
IPR036770	Ankyrin repeat-containing domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0003215	cardiac right ventricle morphogenesis	IMP
biological_process	GO:0003229	ventricular cardiac muscle tissue development	IMP
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0009791	post-embryonic development	IMP
biological_process	GO:0031076	embryonic camera-type eye development	IMP
biological_process	GO:0035264	multicellular organism growth	IMP
biological_process	GO:0042633	hair cycle	IMP
biological_process	GO:0045597	positive regulation of cell differentiation	IEA
biological_process	GO:0048871	multicellular organismal homeostasis	IMP
biological_process	GO:0060048	cardiac muscle contraction	IMP
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0030054	cell junction	IEA
cellular_component	GO:0045171	intercellular bridge	IEA
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0008134	transcription factor binding	IEA
molecular_function	GO:0042802	identical protein binding	IEA
molecular_function	GO:0045296	cadherin binding	IEA

Pathways (from Reactome)

Pathway description

Regulation of TP53 Activity through Association with Co-factors

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000266	abnormal cardiac morphology	"anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0000278	abnormal myocardial fiber morphology	"malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]	Show Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0000280	thin ventricular wall	"decreased depth of the cardiac wall of the heart ventricles" [J:45302]	Show Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0000281	abnormal ventricular septum morphology	"abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2 Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000358	abnormal cell content/ morphology	"structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0000410	waved hair	"hair or fur having undulations or a sinusoidal shape" [J:47620]	Show Allelic Composition: Lmo4^tm1.1Gng/Lmo4^tm1.1Gng Genetic Background: involves: 129X1/SvJ Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2 Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0000416	sparse fur	"fur that is significantly less dense" [J:46854]	Show Allelic Composition: Mycn^tm1Psk/Mycn^tm1Psk,Tg(Nes-cre)1Kln/0 Genetic Background: involves: 129 * C57BL/6 * SJL
MP:0001216	abnormal epidermal layer morphology	"anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0001219	thickened epidermis	"increase in the width of the epidermal cell layer in the skin" [J:65146]	Show Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0001222	epidermal hyperplasia	"increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]	Show Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0001242	hyperkeratosis	"increased depth of the corneal layer of the epidermis; thickening of the horny layer of the epidermis" [J:1133]	Show Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2 Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Lmo4^tm1.1Gng/Lmo4^tm1.1Gng Genetic Background: involves: 129X1/SvJ
MP:0001297	microphthalmia	"reduced average size of the eyes" [J:18048]	Show Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2 Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001302	eyelids open at birth	"widely open eyes instead of closed at perinatal stage" [J:51966]	Show Allelic Composition: Lmo4^tm1.1Gng/Lmo4^tm1.1Gng Genetic Background: involves: 129X1/SvJ Allelic Composition: Ppp1r13l^wa3-J/Ppp1r13l^wa3-J Genetic Background: BALB/cJ-Ppp1r13l^wa3-J/J Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2 Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001312	abnormal cornea morphology	"malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0001314	corneal opacity	"complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2 Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001322	abnormal iris morphology	"structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2 Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001325	abnormal retina morphology	"structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2 Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0001340	abnormal eyelid morphology	"malformation of the skin folds covering the front of the eyeball" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J
MP:0001922	reduced male fertility	"reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]	Show Allelic Composition: Ppp1r13l^wa3-J/Ppp1r13l^wa3-J Genetic Background: BALB/cJ-Ppp1r13l^wa3-J/J
MP:0001926	female infertility	"inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]	Show Allelic Composition: Ppp1r13l^wa3-J/Ppp1r13l^wa3-J Genetic Background: BALB/cJ-Ppp1r13l^wa3-J/J
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Patz1^tm1Pchi/Patz1^tm1Pchi Genetic Background: involves: C57BL/6J Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l⁺ Genetic Background: involves: 129 * C57BL/6J
MP:0002190	disorganized myocardium	"malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]	Show Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0002656	abnormal keratinocyte differentiation	"developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Grk2^tm1Gwd/Grk2^tm1Gwd,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0002754	dilated right ventricle	"an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Lmo4^tm1.1Gng/Lmo4^tm1.1Gng Genetic Background: involves: 129X1/SvJ Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0002795	dilated cardiomyopathy	"decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Lmo4^tm1.1Gng/Lmo4^tm1.1Gng Genetic Background: involves: 129X1/SvJ
MP:0002952	ventricular cardiomyopathy	"diseases of the ventricles of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0003077	abnormal cell cycle	"failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]	Show Allelic Composition: Grk2^tm1Gwd/Grk2^tm1Gwd,Cd79a^tm1(cre)Reth/Cd79a⁺ Genetic Background: involves: 129 * BALB/c * C57BL/6
MP:0003078	aphakia	"absence of the crystalline lens of the eye" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2 Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0003141	cardiac fibrosis	"formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0003393	decreased cardiac output	"reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0005048	thrombosis	"formation within a tissue or the vascular lumen of a thrombus, an aggregation of coagulated blood containing platelets, fibrin, and entrapped cellular elements " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Lmo4^tm1.1Gng/Lmo4^tm1.1Gng Genetic Background: involves: 129X1/SvJ
MP:0005140	decreased cardiac muscle contractility	"inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Lmo4^tm1.1Gng/Lmo4^tm1.1Gng Genetic Background: involves: 129X1/SvJ
MP:0005329	abnormal cardiac muscle morphology	"anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2 Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0005330	cardiomyopathy	"diseases of the heart (myocardium); may result from many causes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:80681]	Show Allelic Composition: Ppp1r13l^wa3-J/Ppp1r13l^wa3-J Genetic Background: BALB/cJ-Ppp1r13l^wa3-J/J
MP:0005542	corneal vascularization	"formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2 Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0005598	decreased ventricle muscle contractility	"reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]	Show Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0006085	myocardial necrosis	"pathological cell death of the cardiac muscle cells, usually due to irreversible damage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92722]	Show Allelic Composition: Lmo4^tm1.1Gng/Lmo4^tm1.1Gng Genetic Background: involves: 129X1/SvJ
MP:0006138	congestive heart failure	"the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ppp1r13l^wa3-J/Ppp1r13l^wa3-J Genetic Background: BALB/cJ-Ppp1r13l^wa3-J/J
MP:0006236	absent meibomian glands	"missing meibomian glands" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2 Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0006267	abnormal intercalated disc morphology	"any structural abnormality in the electron dense junctional complex, at the end to end contacts of cardiac muscle cells, that contains two types of membrane junctions i.e. gap junctions and desmosomes" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:64280]	Show Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0008008	early cellular replicative senescence	"increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺,Ppp1r13l^tm1Xlu/Ppp1r13l^tm1Xlu Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
MP:0008022	dilated heart ventricles	"the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0008028	pregnancy-related premature death	"death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmo4^tm1.1Gng/Lmo4^tm1.1Gng Genetic Background: involves: 129X1/SvJ
MP:0008950	ventricular tachycardia	"paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0009264	failure of eyelid fusion	"the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2 Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0009351	thin hair shaft	"the average diameter of coat hair is less than the average diameter of hair from normal individuals" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Lmo4^tm1.1Gng/Lmo4^tm1.1Gng Genetic Background: involves: 129X1/SvJ
MP:0009416	cardiac muscle degeneration	"pathological deterioration of cardiac muscle tissue, often accompanied by loss of function" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0009584	decreased keratinocyte proliferation	"reduction in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified
MP:0009732	ventricular premature beat	"a heartbeat is initiated by abnormal electrical activation originating in the heart ventricles rather than by the sinoatrial node, the normal heartbeat initiator, before a normal heartbeat would occur" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Lmo4^tm1.1Gng/Lmo4^tm1.1Gng Genetic Background: involves: 129X1/SvJ
MP:0011481	anterior iris synechia	"adhesion of the iris to the cornea" [MGI:anna]	Show Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2 Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0011704	decreased fibroblast proliferation	"reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]	Show Allelic Composition: Rdh10^tm2Ics/Rdh10^tm2Ics Genetic Background: Not Specified Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l⁺ Genetic Background: involves: 129 * BALB/cJ * C57BL/6J Allelic Composition: Gt(ROSA)26Sor^{tm1(cre/ERT)Brn}/Gt(ROSA)26Sor⁺,Ppp1r13l^tm1Xlu/Ppp1r13l^tm1Xlu Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J
MP:0011925	abnormal heart echocardiography feature	"any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]	Show Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0011952	decreased cardiac stroke volume	"reduction in the volume of blood pushed into the aorta with each beat of the heart" [MGI:csmith]	Show Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J
MP:0013744	abnormal conjunctival sac morphology	"any structural anomaly of the space bound by the conjunctival membrane between the palpebral and bulbar conjunctiva, into which the lacrimal fluid is secreted; it is a closed space when eye is closed; when eye is open, the sac is open anteriorly through the palpebral fissure (between the eyelids)" [http://www.medilexicon.com/medicaldictionary.php?t=79277, MGI:Anna]	Show Allelic Composition: Ppp1r13l^woe2/Ppp1r13l^woe2 Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0020409	abnormal cardiac thrombosis	"any anomaly in the formation or presence of thrombi in the heart" [PMID:15870284]	Show Allelic Composition: Ppp1r13l^tm1.1Xlu/Ppp1r13l^tm1.1Xlu Genetic Background: involves: 129 * C57BL/6J

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000022510	Trp63 / O88898 / transformation related protein 63 / TP63* / Q9H3D4* / tumor protein p63*	/ complex / reaction
ENSMUSG00000029026	Trp73 / Q9JJP2 / transformation related protein 73 / TP73* / O15350* / tumor protein p73*	/ complex / reaction
ENSMUSG00000059552	Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*	/ reaction / complex

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr