ENSMUSG00000029026


Mus musculus

Features
Gene ID: ENSMUSG00000029026
  
Biological name :Trp73
  
Synonyms : Q9JJP2 / transformation related protein 73 / Trp73
  
Possible biological names infered from orthology : O15350 / TP73 / tumor protein p73
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 154056253
Gene end: 154140208
  
Corresponding Affymetrix probe sets: 10518989 (MoGene1.0st)   1427697_a_at (Mouse Genome 430 2.0 Array)   1452325_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135281
Ensembl peptide - ENSMUSP00000114736
Ensembl peptide - ENSMUSP00000134196
Ensembl peptide - ENSMUSP00000095368
Ensembl peptide - ENSMUSP00000101268
Ensembl peptide - ENSMUSP00000101269
Ensembl peptide - ENSMUSP00000114418
NCBI entrez gene - 22062     See in Manteia.
MGI - MGI:1336991
RefSeq - NM_001126330
RefSeq - NM_001126331
RefSeq - NM_011642
RefSeq - XM_006538720
RefSeq - XM_006538721
RefSeq - XM_006538722
RefSeq - XM_006538723
RefSeq Peptide - NP_001119803
RefSeq Peptide - NP_035772
RefSeq Peptide - NP_001119802
swissprot - G3UYS2
swissprot - B1AX91
swissprot - Q9JJP2
swissprot - Z4YK94
swissprot - H3BK76
Ensembl - ENSMUSG00000029026
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tp73ENSDARG00000017953Danio rerio
 TP73ENSGALG00000001006Gallus gallus
 TP73ENSG00000078900Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Trp63 / O88898 / transformation related protein 63 / TP63* / Q9H3D4* / tumor protein p63*ENSMUSG0000002251053
Trp53 / P02340 / transformation related protein 53 / TP53* / P04637* / tumor protein p53*ENSMUSG0000005955224


Protein motifs (from Interpro)
Interpro ID Name
 IPR001660  Sterile alpha motif domain
 IPR002117  p53 tumour suppressor family
 IPR008967  p53-like transcription factor, DNA-binding
 IPR010991  p53, tetramerisation domain
 IPR011615  p53, DNA-binding domain
 IPR012346  p53/RUNT-type transcription factor, DNA-binding domain superfamily
 IPR013761  Sterile alpha motif/pointed domain superfamily
 IPR032646  Tumour protein p73
 IPR036674  p53-like tetramerisation domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001836 release of cytochrome c from mitochondria IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0006978 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator IBA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007346 regulation of mitotic cell cycle ISO
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0009791 post-embryonic development IMP
 biological_processGO:0010165 response to X-ray IBA
 biological_processGO:0010243 response to organonitrogen compound IEA
 biological_processGO:0010332 response to gamma radiation IBA
 biological_processGO:0010468 regulation of gene expression ISO
 biological_processGO:0021766 hippocampus development IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0031571 mitotic G1 DNA damage checkpoint IBA
 biological_processGO:0033326 cerebrospinal fluid secretion IMP
 biological_processGO:0034644 cellular response to UV IBA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043508 negative regulation of JUN kinase activity IDA
 biological_processGO:0043523 regulation of neuron apoptotic process IGI
 biological_processGO:0043524 negative regulation of neuron apoptotic process IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045793 positive regulation of cell size IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISS
 biological_processGO:0048546 digestive tract morphogenesis IMP
 biological_processGO:0048666 neuron development IMP
 biological_processGO:0048714 positive regulation of oligodendrocyte differentiation IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0060044 negative regulation of cardiac muscle cell proliferation ISO
 biological_processGO:0071158 positive regulation of cell cycle arrest ISO
 biological_processGO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
 biological_processGO:2001235 positive regulation of apoptotic signaling pathway IGI
 cellular_componentGO:0000785 chromatin IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005667 transcription factor complex IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0030054 cell junction ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0002039 p53 binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IBA
 molecular_functionGO:0003684 damaged DNA binding IBA
 molecular_functionGO:0003690 double-stranded DNA binding IBA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IBA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0097371 MDM2/MDM4 family protein binding ISO


Pathways (from Reactome)
Pathway description
Regulation of TP53 Activity through Association with Co-factors
RUNX1 regulates transcription of genes involved in differentiation of HSCs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000344 absent Cajal-Retzius cell "the absence of a distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [J:60896, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000440 domed skull 
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000487 absent intestinal cell "missing enterocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000503 excessive digestive secretion "increase in the production and/or release of a physiologically active substance (usually but not exclusively in liquid form) from a cell or a gland of the digestive system" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp63tm1Fmc/Trp63+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Bicc1tm1Emdr/Bicc1tm1Emdr
Genetic Background: B6SJL-Bicc1tm1Emdr/J

 MP:0000792 abnormal cortical marginal zone morphology 
Show

Allelic Composition: Trp73tm1(cre)Agof/Trp73tm1(cre)Agof
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000820 abnormal choroid plexus morphology "malformed or absent fringe of the tela choroidea of the cerebral ventricles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:45302]
Show

Allelic Composition: Trp73tm1(cre)Agof/Trp73tm1(cre)Agof
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0000837 abnormal hypothalamus morphology "any malformation or absence of the ventral part of the diencephalon extending from the region of the optic chiasm to the caudal border of the mammillary bodies and forming the inferior and lateral walls of the third ventricle; this region regulates the autonomic nervous system via hormone production and release" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trp73tm1(cre)Agof/Trp73tm1(cre)Agof
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001092 abnormal trigeminal ganglion morphology "malformed group of sensory neuron cell bodies associated with the trigeminal nerve (fifth cranial nerve)" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33038]
Show

Allelic Composition: Trp73tm1(cre)Agof/Trp73tm1(cre)Agof
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Trp63tm1Fmc/Trp63+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0001355 submission towards males "no domineering, assault posture nor hostile physical action toward male mice" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Webster s II New College Dictionary:ISBN 0-395-70869-9, J:60896]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001380 male reduced copulation without impotence "males do not initiate sexual behavior as scored by the presence of copulation plugs (not due to infertility)" [J:57125]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fechm1Pas/Fechm1Pas,hem6/hem6
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0001788 periorbital edema "accumulation of an excessive amount of fluid in the area around the orbit " [MGI:tc, J:60896]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001850 otitis media "middle ear inflammation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001852 conjunctivitis "inflammation of the mucous membrane that lines the inner surface of the eyelids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60896]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001867 rhinitis "inflammation of the mucous membrane of the nose" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001872 sinus inflammation "increase in susceptibility of the hollow cavities in bone (usually but not exclusively those in the skull) to allergens and/or pathogens" [MGI:tc, J:60896]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
Show

Allelic Composition: Trp63tm1Fmc/Trp63+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001893 non-obstructive hydrocephaly "abnormal cerebrospinal fluid absorption where there is no obstruction to fluid flow in the ventricular system" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001911 abnormal cerebrospinal fluid production "change in the normal secretion of the fluid that fills the ventricles and other cavities of the brain and spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001917 intraventricular hemorrhage "bleeding into the brain ventricles" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001921 reduced fertility "diminished ability to produce live offspring" [J:65030]
Show

Allelic Composition: Apctm1Mmt/Apc+,Mmp7tm1Lmm/Mmp7tm1Lmm,Smad4tm1Mmt/Smad4+
Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001928 abnormal ovulation "aberration in the release of an ovum from a rupturing Graafin follicle, normally regulated by a surge in lutenizing hormone" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fechm1Pas/Fechm1Pas,hem6/hem6
Genetic Background: involves: 129 * BALB/c * C57BL/6

 MP:0002007 increased sensitivity to gamma-irradiation "increased incidence of cell death following high levels of gamma-irradiation" [J:51834]
Show

Allelic Composition: Bicc1tm1Emdr/Bicc1tm1Emdr
Genetic Background: B6SJL-Bicc1tm1Emdr/J

 MP:0002018 malignant tumors "higher than normal incidence of locally invasive, destructive and metastatic tumors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:44427]
Show

Allelic Composition: Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002020 increased tumor incidence "greater than average number of tumors, usually a specific type" [MGI:cls, J:34193]
Show

Allelic Composition: Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Trp63tm1Fmc/Trp63+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Trp73tm1Mak/Trp73+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Trp63tm1Fmc/Trp63+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002027 lung adenocarcinoma "malignant neoplasm of epithelial cells in the lung" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:18542]
Show

Allelic Composition: Fechm1Pas/Fechm1Pas,hem6/hem6
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Trp73tm1Mak/Trp73+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Trp73tm1Fmc/Trp73tm1Fmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Trp63tm1Fmc/Trp63+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002032 sarcoma "connective tissue neoplasm associated with the proliferation of mesodermal cells" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
Show

Allelic Composition: Fechm1Pas/Fechm1Pas,hem6/hem6
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Trp73tm1Mak/Trp73+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Trp63tm1Fmc/Trp63+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002048 lung adenoma "benign epithelial neoplasm of the lung" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:57631]
Show

Allelic Composition: Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Trp63tm1Fmc/Trp63+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fechm1Pas/Fechm1Pas,hem6/hem6
Genetic Background: involves: 129 * BALB/c * C57BL/6

Allelic Composition: Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Trp73tm1Fmc/Trp73tm1Fmc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Trp63tm1Fmc/Trp63+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bicc1tm1Emdr/Bicc1tm1Emdr
Genetic Background: B6SJL-Bicc1tm1Emdr/J

 MP:0002243 abnormal vomeronasal organ morphology "any structural anomaly of the specialized portion of the nasal septum that is composed of chemosensitive cells and lies anteriorly in the nasal cavity " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Trp73tm1(cre)Agof/Trp73tm1(cre)Agof
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002499 chronic inflammation "persistent inflammatory response, often caused by persistent infection or during an autoimmune response" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003203 increased neuron apoptosis "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Trp73tm1(cre)Agof/Trp73tm1(cre)Agof
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003207 decreased sensitivity to gamma-irradiation "decreased incidence of cell death following high levels of gamma-irradiation" [J:92917, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp73tm2Mak/Trp73tm2Mak
Genetic Background: either: B6.129P2-Trp73tm2Mak or (involves: 129P2/OlaHsd * C57BL/6J)

Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Trp73tm2Mak/Trp73tm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp73tm1(cre)Agof/Trp73tm1(cre)Agof
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0003667 hemangiosarcoma "a malignant tumor characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and appear as irregular blood-filled or lumpy sacs that are typically filled with blood; rupture of the tumor can cause rapid death from bleeding" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:53511]
Show

Allelic Composition: Trp73tm1Mak/Trp73+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Trp63tm1Fmc/Trp63+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003786 premature aging "earlier than normal occurence of the normal signs of aging" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:97764]
Show

Allelic Composition: Trp63tm1Fmc/Trp63+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004023 abnormal chromosome number "chromosome count is other than the expected diploid chromosome number" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004025 polyploidy "more than two chromosome sets are present" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004207 squamous cell carcinoma "a carcinoma that arises from stratified squamous epithelium that occurs in sites where glandular or columnar epithelium is normally present, such as the skin, esophagus, lungs and cervix" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp63tm1Fmc/Trp63+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004684 intervertebral disk degeneration "retrogressive pathological change of the cartilaginous and gelatinous structure found between vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp63tm1Fmc/Trp63+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005481 chronic myelocytic leukemia "a heterogeneous group of myeloproliferative disorders that may evolve into acute leukemia in late stages " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Trp63tm1Fmc/Trp63+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008031 decreased Cajal-Retzius cell number "reduced number of the distinct population of large, bipolar cells, distributed in a continuous band along the marginal zone of the cortex extending to the molecular layer of the dentate gyrus" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp73tm1(cre)Agof/Trp73tm1(cre)Agof
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Trp73tm1(cre)Agof/Trp73+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Relnrl/Reln+,Trp73tm1(cre)Agof/Trp73+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Riet/Gt(ROSA)26Sor+,Relnrl/Reln+,Trp73tm1(cre)Agof/Trp73+,Wnt3atm1(cre)Eag/Wnt3a+
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

 MP:0008143 abnormal dendrite morphology "any structural anomaly of the highly branched tree-like process of a neuron that serves as a receptive field and conducts impulses toward the cell body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd

 MP:0008267 abnormal hippocampus CA3 region morphology 
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008780 pancreatic acinar cell carcinoma "presence of an adenocarcinoma arising from cells of the pancreas that secrete digestive enzymes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S2/SvPas * 129S4/SvJae * C57BL/6

 MP:0008869 anovulation "complete failure of ovum to be released from an ovarian follicle" [MESH:C13.351.500.056.630.050, MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008871 abnormal ovarian follicle number "abnormal numbers of spheroid cell aggregations in the ovary" [MGI:mnk "Michelle Knowlton, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bicc1tm1Emdr/Bicc1tm1Emdr
Genetic Background: B6SJL-Bicc1tm1Emdr/J

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bicc1tm1Emdr/Bicc1tm1Emdr
Genetic Background: B6SJL-Bicc1tm1Emdr/J

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
Show

Allelic Composition: Bicc1tm1Emdr/Bicc1tm1Emdr
Genetic Background: B6SJL-Bicc1tm1Emdr/J

 MP:0009485 distended ileum "an expansion in the volume of the portion of the small intestine that extends from the jejunum to the colon, as by stretching or distention" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0009541 increased thymocyte apoptosis "increase in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bicc1tm1Emdr/Bicc1tm1Emdr
Genetic Background: B6SJL-Bicc1tm1Emdr/J

 MP:0009542 decreased thymocyte apoptosis "reduction in the number of immature T cells located in the thymus that are undergoing programmed cell death" [CL:0000893, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Trp53tm1Brd/Trp53tm1Brd,Trp73tm2Mak/Trp73tm2Mak
Genetic Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Atmtm1Pmc/Atmtm1Pmc,Trp73tm2Mak/Trp73tm2Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009761 abnormal meiotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during meiosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
Show

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009939 abnormal hippocampus neuron morphology 
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Trp53tm1Tyj/Trp53+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Trp73tm2Mak/Trp73tm2Mak
Genetic Background: either: B6.129P2-Trp73tm2Mak or (involves: 129P2/OlaHsd * C57BL/6J)

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
Show

Allelic Composition: Trp73tm1Mak/Trp73tm1Mak
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Trp73tm1Mak/Trp73+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0013537 increased salivary gland adenoma incidence "greater than the expected number of a benign epithelial neoplasm with a glandular organization arising in any salivary gland, occurring in a specific population in a given time period " [MGI:Anna]
Show

Allelic Composition: Trp63tm1Fmc/Trp63+,Trp73tm1Fmc/Trp73+
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040734 Q5I1X5 / Ppp1r13l / protein phosphatase 1, regulatory (inhibitor) subunit 13 like / Q8WUF5* / protein phosphatase 1 regulatory subunit 13 like*  / complex / reaction
 ENSMUSG00000053110 Yap1 / P46938 / yes-associated protein 1 / P46937*  / complex / reaction
 ENSMUSG00000026510 Trp53bp2 / transformation related protein 53 binding protein 2 / Q13625* / TP53BP2* / tumor protein p53 binding protein 2*  / reaction / complex
 ENSMUSG00000021285 Q62415 / Ppp1r13b / protein phosphatase 1, regulatory (inhibitor) subunit 13B / Q96KQ4* / protein phosphatase 1 regulatory subunit 13B*  / reaction / complex
 ENSMUSG00000029026 Trp73 / Q9JJP2 / transformation related protein 73 / TP73* / O15350* / tumor protein p73*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr