ENSMUSG00000053110


Mus musculus

Features
Gene ID: ENSMUSG00000053110
  
Biological name :Yap1
  
Synonyms : P46938 / Yap1 / yes-associated protein 1
  
Possible biological names infered from orthology : P46937
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A1
Gene start: 7931999
Gene end: 8004596
  
Corresponding Affymetrix probe sets: 10590808 (MoGene1.0st)   1416487_a_at (Mouse Genome 430 2.0 Array)   1448363_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000133959
Ensembl peptide - ENSMUSP00000069554
Ensembl peptide - ENSMUSP00000083772
Ensembl peptide - ENSMUSP00000134250
Ensembl peptide - ENSMUSP00000134007
Ensembl peptide - ENSMUSP00000134237
NCBI entrez gene - 22601     See in Manteia.
MGI - MGI:103262
RefSeq - XM_006509853
RefSeq - XM_006509852
RefSeq - XM_006509856
RefSeq - XM_006509855
RefSeq - NM_001171147
RefSeq - NM_009534
RefSeq - XM_006509857
RefSeq - XM_006509854
RefSeq Peptide - NP_033560
RefSeq Peptide - NP_001164618
swissprot - P46938
swissprot - G3UYA6
swissprot - G3UY62
swissprot - G3UYW7
swissprot - G3UYV4
Ensembl - ENSMUSG00000053110
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 yap1ENSDARG00000068401Danio rerio
 YAP1ENSGALG00000038154Gallus gallus
 YAP1ENSG00000137693Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wwtr1 / Q9EPK5 / WW domain containing transcription regulator 1 / Q9GZV5*ENSMUSG0000002780341


Protein motifs (from Interpro)
Interpro ID Name
 IPR001202  WW domain
 IPR036020  WW domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001570 vasculogenesis IMP
 biological_processGO:0003143 embryonic heart tube morphogenesis IGI
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0006975 DNA damage induced protein phosphorylation ISS
 biological_processGO:0008283 cell proliferation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0010837 regulation of keratinocyte proliferation IMP
 biological_processGO:0030216 keratinocyte differentiation IMP
 biological_processGO:0030857 negative regulation of epithelial cell differentiation IDA
 biological_processGO:0030903 notochord development IGI
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0033148 positive regulation of intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0035019 somatic stem cell population maintenance IDA
 biological_processGO:0035329 hippo signaling IGI
 biological_processGO:0042127 regulation of cell proliferation IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046622 positive regulation of organ growth IDA
 biological_processGO:0048339 paraxial mesoderm development IGI
 biological_processGO:0048368 lateral mesoderm development IGI
 biological_processGO:0050767 regulation of neurogenesis IEA
 biological_processGO:0050847 progesterone receptor signaling pathway IEA
 biological_processGO:0060242 contact inhibition IEA
 biological_processGO:0060449 bud elongation involved in lung branching IMP
 biological_processGO:0060487 lung epithelial cell differentiation IMP
 biological_processGO:0060828 regulation of canonical Wnt signaling pathway IGI
 biological_processGO:0065003 protein-containing complex assembly IEA
 biological_processGO:0071300 cellular response to retinoic acid IDA
 biological_processGO:0071480 cellular response to gamma radiation IEA
 biological_processGO:0072091 regulation of stem cell proliferation IEA
 biological_processGO:0072307 regulation of metanephric nephron tubule epithelial cell differentiation IGI
 biological_processGO:0090263 positive regulation of canonical Wnt signaling pathway IDA
 biological_processGO:1902459 positive regulation of stem cell population maintenance IMP
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 biological_processGO:2000737 negative regulation of stem cell differentiation IDA
 biological_processGO:2001237 negative regulation of extrinsic apoptotic signaling pathway IGI
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005667 transcription factor complex IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0071148 TEAD-1-YAP complex IEA
 cellular_componentGO:0071149 TEAD-2-YAP complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding IPI
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003714 transcription corepressor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IPI
 molecular_functionGO:0033613 activating transcription factor binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA
 molecular_functionGO:0070064 proline-rich region binding IPI


Pathways (from Reactome)
Pathway description
Nuclear signaling by ERBB4
Signaling by Hippo
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX3 regulates YAP1-mediated transcription


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Wwtr1tm1.1Eno/Wwtr1+,Yap1tm1.1Eno/Yap1tm1.1Eno,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0000351 increased cell proliferation "greater than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kiss1rtm1.1Lex/Kiss1r+
Genetic Background: involves: 129S4/SvJae

 MP:0000352 decreased cell proliferation "less than the normal growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kiss1rtm1.1Lex/Kiss1r+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Yap1tm1.1Fcam/Yap1tm2.1Fcam,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0000521 abnormal kidney cortex "anomalous structure or development of the outer area of the kidney, which contains the glomerular capillaries and the capsula glomeruli that enclose it " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ano6Gt(RRF355)Byg/Ano6Gt(RRF355)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000524 reduced renal tubule number "fewer loops of Henle and collecting ducts" [J:40203]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Allelic Composition: Wwtr1tm1Hmc/Wwtr1tm1Hmc,Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl

 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Allelic Composition: Wwtr1tm1Hmc/Wwtr1tm1Hmc,Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Yap1tm1.1Dupa/Yap1tm1.1Dupa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Yap1tm1.1Dupa/Yap1+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Yap1tm2.1Dupa/Yap1tm2.1Dupa
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lats1tm1Noj/Lats1tm1Noj,Lats2tm1.1Dupa/Lats2tm1.1Dupa,Wwtr1tm1.2Eno/Wwtr1tm1.2Eno,Yap1tm1.1Dupa/Yap1tm1.1Dupa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
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Allelic Composition: Yap1tm1.1Dupa/Yap1tm1.1Dupa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Yap1tm1.1Dupa/Yap1tm1.1Dupa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0001191 abnormal skin condition "anomalous state of the skin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kiss1rtm1.1Lex/Kiss1r+
Genetic Background: involves: 129S4/SvJae

 MP:0001199 thin skin "reduced thickness of the outer protective layer of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
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Allelic Composition: Kiss1rtm1.1Lex/Kiss1r+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Yap1tm1.1Fcam/Yap1tm2.1Fcam,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001216 abnormal epidermal layer morphology "anomalous structure or development of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kiss1rtm1.1Lex/Kiss1r+
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Yap1tm1.1Fcam/Yap1tm2.1Fcam,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

 MP:0001218 thin epidermis "reduced thickness of the superficial epithelial portion of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Kiss1rtm1.1Lex/Kiss1r+
Genetic Background: involves: 129S4/SvJae

 MP:0001231 abnormal basal cell layer morphology "structural anomaly of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kiss1rtm1.1Lex/Kiss1r+
Genetic Background: involves: 129S4/SvJae

 MP:0001240 abnormal cornified layer morphology "structural or developmental anomaly of the outer layer of the epidermis, consisting of several layers of flat keratinized non-nucleated cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Kiss1rtm1.1Lex/Kiss1r+
Genetic Background: involves: 129S4/SvJae

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2+,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0001700 abnormal embryo turning "atypical axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (Mus:E8.5-E9.5) such that the curvature of the entire trunk region is reversed and the neural ectoderm moves to the convex region and the midgut region becomes located in the concave region" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tead1tm1Hssk/Tead1+,Tead2tm1Hssk/Tead2tm1Hssk,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0001704 abnormal dorsal-ventral axis patterning "anomaly in the development or formation of the axis that runs from the front to the back surface of the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0001721 absent blood islands "missing pools of blood in the yolk sac" [J:12623]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0001723 disorganized vascular plexus 
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2+,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0001855 atrial thrombosis "formation or presence of a thrombus in the atria of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Wwtr1tm1.1Eno/Wwtr1tm1.1Eno,Yap1tm1.1Eno/Yap1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Kiss1rtm1.1Lex/Kiss1r+
Genetic Background: involves: 129S4/SvJae

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Wwtr1tm1.1Eno/Wwtr1tm1.1Eno,Yap1tm1.1Eno/Yap1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tead1tm1Hssk/Tead1+,Tead2tm1Hssk/Tead2tm1Hssk
Genetic Background: either: (involves: C57BL/6 * CBA) or (involves: C57BL/6 * CBA * CD-1)

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

Allelic Composition: Tead1tm1Hssk/Tead1tm1Hssk,Tead2tm1Hssk/Tead2+,Yap1tm1Smil/Yap1+
Genetic Background: either: (involves: 129S/SvEv * C57BL/6 * CBA) or (involves: 129S/SvEv * C57BL/6 * CBA * CD-1)

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Yap1tm1.1Dupa/Yap1tm1.1Dupa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: GckGls006/Gck+
Genetic Background: C3HeB/FeJ-GckGls006

Allelic Composition: Wwtr1tm1.1Eno/Wwtr1+,Yap1tm1.1Eno/Yap1tm1.1Eno,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Wwtr1tm1.1Eno/Wwtr1tm1.1Eno,Yap1tm1.1Eno/Yap1+,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0002796 impaired skin barrier function "impaired ability of the skin to regulate water loss; frequently leads to dehydration" [J:56641]
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Allelic Composition: Kiss1rtm1.1Lex/Kiss1r+
Genetic Background: involves: 129S4/SvJae

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Yap1tm1.1Dupa/Yap1tm1.1Dupa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002929 abnormal bile duct development "incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Yap1tm1.1Dupa/Yap1tm1.1Dupa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Yap1tm1.1Dupa/Yap1tm1.1Dupa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Ctgftm1.1Alea/Ctgftm1.1Alea,Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA

 MP:0003014 abnormal kidney medulla morphology "anomalous structure of the inner portion of the kidney consisting of the renal pyramids" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:88636, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0003037 increased infarction size "increased size of necrotic area from normal of the myocardium resulting from a sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003046 liver cirrhosis "liver disease in which the occurrence of fibrotic nodules cause diffuse damage to parenchymal cells, disruptions in microcirculation, vascular anatomy and hepatic architecture, resulting in hepatic dysfunction and ultimately, hepatic failure" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Yap1tm1.1Dupa/Yap1tm1.1Dupa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Wwtr1tm1.1Eno/Wwtr1+,Yap1tm1.1Eno/Yap1tm1.1Eno,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0003252 abnormal bile duct physiology "anomalous action or function of the channels that secrete bile from the liver to the gall bladder and intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Yap1tm2.1Dupa/Yap1tm2.1Dupa
Genetic Background: involves: 129P2/OlaHsd

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Yap1tm1.1Dupa/Yap1+,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Yap1tm1.1Dupa/Yap1tm1.1Dupa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Yap1tm1c(KOMP)Mbp/Yap1tm1c(KOMP)Mbp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA

 MP:0003384 abnormal ventral body wall "malformation in the anterior portion of a human body or the lower surface of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0003446 renal hypoplasia "decreased cell number in the kidney leading to reduced size" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0003624 anuria "inability to form or excrete urine" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Wwtr1tm1Hmc/Wwtr1tm1Hmc,Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl

 MP:0003885 abnormal rostro-caudal body axis extension "anomaly in or failure of the long (rostral-caudal) axis of the body to elongate normally once patterning has been established" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Yap1tm1.1Dupa/Yap1tm1.1Dupa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Yap1tm1.1Dupa/Yap1tm1.1Dupa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0004193 abnormal kidney papilla morphology "any structural anomaly of the apex of the renal pyramid that projects into a calyx" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0004499 increased incidence of chemically-induced tumors "higher than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mapk1tm1Gela/Mapk1tm1Gela,Mapk3tm1Gela/Mapk3tm1Gela,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

 MP:0004505 decreased renal glomerulus number "reduced number of the capillary loops of the kidney that normally function as a filtration unit" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Allelic Composition: Wwtr1tm1Hmc/Wwtr1tm1Hmc,Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * C57BL/6NCrl

 MP:0004755 abnormal loop of Henle "any structural anomaly of the section of the renal tubule in the kidney medulla with a hairpin bend; consists of a descending limb and an ascending limb, and is situated between the proximal convoluted tubule to the distal convoluted tubule; it functions to reabsorb water and ions from the urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0004936 abnormal ureteric bud branching morphogenesis "partial or complete failure of the ureteric bud to repeatedly divide into lobules during development of the kidney" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: GckGls006/Gck+
Genetic Background: C3HeB/FeJ-GckGls006

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
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Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S/SvEv

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Yap1tm1.1Dupa/Yap1tm1.1Dupa,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sept9tm2.1Emfu/Sept9tm2.1Emfu,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0008140 podocyte foot process effacement "thinning of the footlike extension of podocytes that interdigitate with one another to form the walls of the glomerular capillaries" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sav1tm1.1Dupa/Sav1tm1.1Dupa,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

 MP:0008883 abnormal enterocyte proliferation "anomaly in the ability of the enterocyte cell population to undergo expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sav1tm1.1Dupa/Sav1tm1.1Dupa,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

 MP:0008885 increased enterocyte apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sav1tm1.1Dupa/Sav1tm1.1Dupa,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

 MP:0009714 thin epidermis stratum basale "reduced thickness of the deepest layer of the epidermis, which is composed of dividing stem cells and anchoring cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Kiss1rtm1.1Lex/Kiss1r+
Genetic Background: involves: 129S4/SvJae

 MP:0009766 increased sensitivity to xenobiotic induced morbidity/mortality "decrease in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Sav1tm1.1Dupa/Sav1tm1.1Dupa,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sav1tm1.1Dupa/Sav1tm1.1Dupa,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * SJL

 MP:0010306 increased hamartoma incidence "greater than the expected number of benign focal malformations in a specific population in a given time period; results from faulty development of an organ, and is composed of an abnormal mixture of tissue elements, or an abnormal proportion of a single element normally present at that site" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Yap1tm2.1Dupa/Yap1tm2.1Dupa
Genetic Background: involves: 129P2/OlaHsd

 MP:0010500 myocardium hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the heart myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Wwtr1tm1.1Eno/Wwtr1+,Yap1tm1.1Eno/Yap1tm1.1Eno,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0011004 abnormal epidermal stem cell morphology "any structural anomaly of a somatic stem cell that is part of the epidermis" [CL:1000428]
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Allelic Composition: Kiss1rtm1.1Lex/Kiss1r+
Genetic Background: involves: 129S4/SvJae

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

Allelic Composition: Wwtr1tm1.1Eno/Wwtr1+,Yap1tm1.1Eno/Yap1tm1.1Eno,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Yap1tm1.1Fcam/Yap1tm2.1Fcam,Tg(KRT14-cre)1Amc/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Wwtr1tm1.1Eno/Wwtr1tm1.1Eno,Yap1tm1.1Eno/Yap1tm1.1Eno,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
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Allelic Composition: ArTfm-Jms/Y
Genetic Background: C57BL/6JJms

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

Allelic Composition: Yap1tm1.1Eno/Yap1tm1.1Eno,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S/SvEv

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0011205 excessive folding of visceral yolk sac "the appearance of wrinkles or folds on the surface of the visceral yolk sac" [MGI:csmith, PMID:17881493]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0011334 abnormal nephrogenic zone morphology "any structural anomaly in the region found at the periphery of the developing metanephros within which the metanephric mesenchyme aggregates around the tips of the ureteric tree to form the nephrons; in rodents including mice, this region normally disappears within the first postnatal week when nephrogenesis ceases and only mature nephrons are present; in humans, it is lost by 36 weeks of gestation" [PMID:17452023]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0011364 abnormal metanephros morphology "any structural anomaly of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; the metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine" [GO:0001656]
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Allelic Composition: Yap1tm1Hmc/Yap1tm1Hmc,Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J * C57BL/6NCrl

 MP:0012135 embryonic-extraembryonic boundary constriction "an invagination or pinching in the visceral endoderm that is centered at the boundary between embryonic and extra-embryonic regions of the developing embryo, often resulting in physical separation of embryonic and extraembryonic ectoderm" [MGI:csmith]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0012236 abnormal cholangiocyte morphology "any structural anomaly of the epithelial cells of the bile duct that have primary cilia extending from their apical membrane into the ductal lumen; cholangiocytes are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts" [PMID:22961800]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Yap1tm1c(KOMP)Mbp/Yap1tm1c(KOMP)Mbp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA

 MP:0012740 abnormal posterior primitive streak morphology "any structural anomaly of the posterior region of the vertebrate primitive streak which gives rise to the extraembryonic mesoderm" [MGI:anna]
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Allelic Composition: Nkx2-2tm1Jlr/Nkx2-2tm1Jlr,Nkx6-1tm1Jlr/Nkx6-1tm1Jlr
Genetic Background: involves: 129 * 129X1/SvJ * C57BL/6J

 MP:0013611 abnormal bile duct epithelium morphology "any structural anomaly of the epithelium lining the intrahepatic and extrahepatic bile ducts" [MGI:Anna]
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Allelic Composition: Nf2tm2Gth/Nf2tm2Gth,Yap1tm2.1Dupa/Yap1tm2.1Dupa
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Lats1tm1Noj/Lats1tm1Noj,Lats2tm1.1Dupa/Lats2tm1.1Dupa,Wwtr1tm1.2Eno/Wwtr1tm1.2Eno,Yap1tm1.1Dupa/Yap1tm1.1Dupa
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021959 Lats2 / Q7TSJ6 / Serine/threonine-protein kinase LATS2 / Q9NRM7* / large tumor suppressor kinase 2*  / reaction
 ENSMUSG00000026842 Abl1 / P00520 / c-abl oncogene 1, non-receptor tyrosine kinase / P00519* / ABL proto-oncogene 1, non-receptor tyrosine kinase*  / reaction
 ENSMUSG00000040021 Lats1 / Q8BYR2 / Serine/threonine-protein kinase LATS1 / O95835* / large tumor suppressor kinase 1*  / reaction
 ENSMUSG00000030796 Tead2 / P48301 / TEA domain family member 2 / Q15562* / TEA domain transcription factor 2*  / complex / reaction
 ENSMUSG00000070691 Runx3 / Q64131 / Runt-related transcription factor 3 / Q13761*  / reaction / complex
 ENSMUSG00000041688 Amot / Q8VHG2 / Angiomotin / Q4VCS5*  / reaction / complex
 ENSMUSG00000062209 Erbb4 / Q61527 / Receptor tyrosine-protein kinase erbB-4 ERBB4 intracellular domain / Q15303* / erb-b2 receptor tyrosine kinase 4*  / reaction / complex
 ENSMUSG00000031885 Cbfb / Q08024 / Core-binding factor subunit beta / Q13951* / core-binding factor beta subunit*  / complex / reaction
 ENSMUSG00000032531 Amotl2 / Q8K371 / Angiomotin-like protein 2 / Q9Y2J4* / angiomotin like 2*  / reaction / complex
 ENSMUSG00000002249 Tead3 / P70210 / TEA domain family member 3 / Q99594* / TEA domain transcription factor 3*  / complex / reaction
 ENSMUSG00000018326 Ywhab / Q9CQV8 / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide / P31946* / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta*  / complex / reaction
 ENSMUSG00000013076 Amotl1 / Q9D4H4 / Angiomotin-like protein 1 / Q8IY63* / angiomotin like 1*  / complex / reaction
 ENSMUSG00000024812 Tjp2 / Q9Z0U1 / Tight junction protein ZO-2 / Q9UDY2* / AL358113.1* / tight junction protein 2*  / complex / reaction
 ENSMUSG00000029026 Trp73 / Q9JJP2 / transformation related protein 73 / TP73* / O15350* / tumor protein p73*  / reaction / complex






 

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