ENSMUSG00000021959


Mus musculus

Features
Gene ID: ENSMUSG00000021959
  
Biological name :Lats2
  
Synonyms : Lats2 / Q7TSJ6 / Serine/threonine-protein kinase LATS2
  
Possible biological names infered from orthology : large tumor suppressor kinase 2 / Q9NRM7
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: C3
Gene start: 57689662
Gene end: 57758388
  
Corresponding Affymetrix probe sets: 10420413 (MoGene1.0st)   1419678_at (Mouse Genome 430 2.0 Array)   1419679_at (Mouse Genome 430 2.0 Array)   1425420_s_at (Mouse Genome 430 2.0 Array)   1426156_at (Mouse Genome 430 2.0 Array)   1437101_at (Mouse Genome 430 2.0 Array)   1439441_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134321
Ensembl peptide - ENSMUSP00000022531
Ensembl peptide - ENSMUSP00000038982
Ensembl peptide - ENSMUSP00000077130
Ensembl peptide - ENSMUSP00000133379
Ensembl peptide - ENSMUSP00000133857
Ensembl peptide - ENSMUSP00000133976
Ensembl peptide - ENSMUSP00000134142
NCBI entrez gene - 50523     See in Manteia.
MGI - MGI:1354386
RefSeq - XM_006519225
RefSeq - NM_015771
RefSeq - NM_153382
RefSeq - XM_006519224
RefSeq Peptide - NP_700431
RefSeq Peptide - NP_056586
swissprot - G3UWQ0
swissprot - Q7TSJ6
swissprot - Q8VHE1
swissprot - G3UY78
swissprot - G3UYM3
swissprot - G3UXX1
swissprot - G3UZ29
swissprot - Q8VHE2
Ensembl - ENSMUSG00000021959
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lats2ENSDARG00000078864Danio rerio
 LATS2ENSG00000150457Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Lats2 / Q9NRM7* / large tumor suppressor kinase 2*ENSMUSG0000011494282
Lats1 / Q8BYR2 / Serine/threonine-protein kinase LATS1 / O95835* / large tumor suppressor kinase 1*ENSMUSG0000004002153
Stk38 / Q91VJ4 / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA. / Q15208* / serine/threonine kinase 38*ENSMUSG0000002400619
Q7TSE6 / Stk38l / Mus musculus serine/threonine kinase 38 like (Stk38l), transcript variant 2, mRNA. / Q9Y2H1* / serine/threonine kinase 38 like*ENSMUSG0000000163019
Q7TT50 / Cdc42bpb / CDC42 binding protein kinase beta / Q9Y5S2*ENSMUSG0000002127917
Q3UU96 / Cdc42bpa / Serine/threonine-protein kinase MRCK alpha / Q5VT25* / CDC42 binding protein kinase alpha*ENSMUSG0000002649016
Rock1 / P70335 / Rho-associated protein kinase 1 / Q13464* / Rho associated coiled-coil containing protein kinase 1*ENSMUSG0000002429016
Q80UW5 / Cdc42bpg / Serine/threonine-protein kinase MRCK gamma / Q6DT37* / CDC42 binding protein kinase gamma*ENSMUSG0000002476916
Rock2 / Rho associated coiled-coil containing protein kinase 2 / O75116*ENSMUSG0000002058015
Cit / citron rho-interacting serine/threonine kinase / O14578*ENSMUSG0000002951615
Dmpk / P54265 / Myotonin-protein kinase / Q09013* / DM1 protein kinase*ENSMUSG0000003040915


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR009060  UBA-like superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IDA
 biological_processGO:0001827 inner cell mass cell fate commitment IGI
 biological_processGO:0001828 inner cell mass cellular morphogenesis IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0009755 hormone-mediated signaling pathway ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030216 keratinocyte differentiation IGI
 biological_processGO:0034613 cellular protein localization IGI
 biological_processGO:0035329 hippo signaling ISO
 biological_processGO:0035556 intracellular signal transduction ISS
 biological_processGO:0043065 positive regulation of apoptotic process IBA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity ISS
 biological_processGO:0046620 regulation of organ growth IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway ISO
 cellular_componentGO:0000922 spindle pole ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000006262 Mob1b / Q8BPB0 / MOB kinase activator 1B / Q7L9L4*  / complex / reaction
 ENSMUSG00000022329 Stk3 / Q9JI10 / Mus musculus serine/threonine kinase 3 (Stk3), transcript variant 2, mRNA. / Q13188* / serine/threonine kinase 3*  / reaction
 ENSMUSG00000018209 Stk4 / Q9JI11 / serine/threonine kinase 4 / Q13043*  / reaction
 ENSMUSG00000043131 Mob1a / Q921Y0 / MOB kinase activator 1A / Q9H8S9*  / reaction / complex
 ENSMUSG00000027803 Wwtr1 / Q9EPK5 / WW domain containing transcription regulator 1 / Q9GZV5*  / reaction
 ENSMUSG00000039577 Nphp4 / P59240 / Mus musculus nephronophthisis 4 (juvenile) homolog (human) (Nphp4), transcript variant 2, mRNA. / O75161* / nephrocystin 4*  / complex / reaction
 ENSMUSG00000053110 Yap1 / P46938 / yes-associated protein 1 / P46937*  / reaction
 ENSMUSG00000018849 Wwc1 / Q5SXA9 / WW, C2 and coiled-coil domain containing 1 / Q8IX03* / WW and C2 domain containing 1*  / reaction / complex






 

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