ENSMUSG00000006262


Mus musculus

Features
Gene ID: ENSMUSG00000006262
  
Biological name :Mob1b
  
Synonyms : Mob1b / MOB kinase activator 1B / Q8BPB0
  
Possible biological names infered from orthology : Q7L9L4
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E1
Gene start: 88720855
Gene end: 88764220
  
Corresponding Affymetrix probe sets: 10523001 (MoGene1.0st)   1430564_at (Mouse Genome 430 2.0 Array)   1455184_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006424
Ensembl peptide - ENSMUSP00000108855
NCBI entrez gene - 68473     See in Manteia.
MGI - MGI:1915723
RefSeq - NM_026735
RefSeq Peptide - NP_081011
swissprot - Q3T9U1
swissprot - Q3UDM0
swissprot - Q8BPB0
Ensembl - ENSMUSG00000006262
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mob1baENSDARG00000009169Danio rerio
 mob1bbENSDARG00000012953Danio rerio
 MOB1BENSGALG00000011573Gallus gallus
 MOB1BENSG00000173542Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mob1a / Q921Y0 / MOB kinase activator 1A / Q9H8S9*ENSMUSG0000004313196
Mob3b / Q8VE04 / MOB kinase activator 3B / Q86TA1*ENSMUSG0000007391053
Mob3a / Q8BSU7 / MOB kinase activator 3A / Q96BX8*ENSMUSG0000000334853
Mob3c / Q8BJG4 / MOB kinase activator 3C / Q70IA8*ENSMUSG0000002870948
Mob2 / Q8VI63 / Mus musculus MOB kinase activator 2 (Mob2), transcript variant 2, mRNA. / Q70IA6* / MOB kinase activator 2*ENSMUSG0000002514739


Protein motifs (from Interpro)
Interpro ID Name
 IPR005301  MOB kinase activator family
 IPR036703  MOB kinase activator superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031952 regulation of protein autophosphorylation IEA
 biological_processGO:0035329 hippo signaling IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019209 kinase activator activity ISS
 molecular_functionGO:0019900 kinase binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000120 malocclusion "perturbations in the normal patterned arrangement of the teeth or alignment of the jaw, resulting in the incorrect position of biting or chewing surfaces of the upper and lower teeth" [J:61509]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000420 ruffled hair "fuzzy, irregular appearance of the hair" [J:50844]
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Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000452 abnormal mouth morphology "anomalous structure or development of the oral cavity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000572 abnormal autopod morphology "malformation of the hand or foot" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0001211 wrinkled skin "irregular folds and/or indentations on the skin" [J:19212]
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Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001222 epidermal hyperplasia "increase in size of the epidermis due to increase in epidermal cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0002102 abnormal ear morphology "structural or developmental anomaly of any of the structures involved in the ear or vestibular system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

 MP:0002655 abnormal keratinocyte morphology "structural or developmental anomaly of the cells of the epidermis that produce keratin in the process of differentiating into the dead and fully keratinized cells of the stratum corneum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Wwtr1tm1Hku/Wwtr1tm1Hku,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Ctgftm1.1Alea/Ctgftm1.1Alea,Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Yap1tm1c(KOMP)Mbp/Yap1tm1c(KOMP)Mbp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0003158 dysphagia "difficulty in swallowing food or liquid" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0003252 abnormal bile duct physiology "anomalous action or function of the channels that secrete bile from the liver to the gall bladder and intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0003324 liver adenoma "benign epithelial neoplasm of the liver" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Wwtr1tm1Hku/Wwtr1tm1Hku,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Ctgftm1.1Alea/Ctgftm1.1Alea,Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Yap1tm1c(KOMP)Mbp/Yap1tm1c(KOMP)Mbp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003427 parakeratosis "abnormal retention of the nuclei of the keratinocytes in the stratum corneum of the epidermis" [smb:Susan M Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0003453 abnormal keratinocyte physiology "atypical function of the cells of the epidermis that produce keratin" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:94860]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0003769 abnormal lip morphology "anomalous structure or development of the fleshy margins of the mouth" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0003789 osteosarcoma "malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0004492 abnormal orientation of inner hair cell stereociliary bundles "misorientation or rotation of inner hair cell (IHC) stereociliary bundles, resulting in defective planar cell polarity of the inner ear sensory epithelium" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0008014 lung tumor "presence of abnormal, rapidly proliferating cells on the lung usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009581 decreased keratinocyte apoptosis "reduction in the number of keratinocytes undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0009583 increased keratinocyte proliferation "increase in the expansion rate of keratinocytes by cell division" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0009760 abnormal mitotic spindle "an anomaly in the formation of the ellipsoidal (bipolar) collection of fibers visible during nuclear division and cytokinesis responsible for accurate segregation of chromosomes during mitosis" [ISBN:8185198691 "Rieger R et al Eds Glossary of Genetics Classical and Molecular"]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0009877 exostosis "a projection of bone, sometimes a benign tumor, that is capped by cartilage and arises from a bone that develops from cartilage" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010293 increased integument system tumor incidence "greater than the expected number of tumors originating in the integument system in a given population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010297 increased hepatobiliary system tumor incidence 
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Albtm1(cre/ERT2)Mtz/Alb+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010300 increased skin tumor incidence "greater than the expected number of neoplasms in the skin tissue usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010315 increased cholangiocarcinoma incidence "greater than the expected number of malignant adenocarcimomas arising in the intrahepatic bile duct epithelium, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0010318 increased salivary gland tumor incidence "greater than the expected number of neoplams in the salivary gland occurring in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010363 increased fibrosarcoma incidence "greater than the expected number of a highly aggressive malignant neoplasm arising from fibrous connective tissue, in a specific population in a given time period" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Mcm4Sdla/Mcm4+
Genetic Background: involves: C57BL/6

Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0011095 complete embryonic lethality between implantation and placentation "death of all organisms of a given genotype in a population between the point of implantation and the initiation of placentation (Mus: E4.5 to less than E9)" [MGI:csmith]
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Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011686 increased epidermal stem cell number "greater than expected number of somatic stem cells that are part of the epidermis" [CL:1000428, MGI:csmith]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Tg(KRT14-cre/ERT)20Efu/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CD-1

 MP:0012114 absent inner cell mass proliferation 
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Allelic Composition: Mob1atm1.2Asuz/Mob1a+,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0012236 abnormal cholangiocyte morphology "any structural anomaly of the epithelial cells of the bile duct that have primary cilia extending from their apical membrane into the ductal lumen; cholangiocytes are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts" [PMID:22961800]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Wwtr1tm1Hku/Wwtr1tm1Hku,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

Allelic Composition: Ctgftm1.1Alea/Ctgftm1.1Alea,Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Yap1tm1c(KOMP)Mbp/Yap1tm1c(KOMP)Mbp,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * DBA

Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+,Tgfbr2tm1Roes/Tgfbr2tm1Roes
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0013119 abdomen swellings "appearance of abnormal enlargements of all descriptions (hard, soft, different shapes etc) under the skin in the abdominal region" [MGI:Ahmad_Retha]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn

 MP:0014038 increased hepatocyte number "greater than normal number of parenchymal liver cells" [MGI:monikat]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: B6.Cg-Mob1bGt(CC0690)Wtsi Mob1atm1.1Asuz Speer6-ps1Tg(Alb-cre)21Mgn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000040021 Lats1 / Q8BYR2 / Serine/threonine-protein kinase LATS1 / O95835* / large tumor suppressor kinase 1*  / complex / reaction
 ENSMUSG00000021959 Lats2 / Q7TSJ6 / Serine/threonine-protein kinase LATS2 / Q9NRM7* / large tumor suppressor kinase 2*  / complex / reaction
 ENSMUSG00000022329 Stk3 / Q9JI10 / Mus musculus serine/threonine kinase 3 (Stk3), transcript variant 2, mRNA. / Q13188* / serine/threonine kinase 3*  / reaction
 ENSMUSG00000018209 Stk4 / Q9JI11 / serine/threonine kinase 4 / Q13043*  / reaction






 

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