ENSMUSG00000018209


Mus musculus

Features
Gene ID: ENSMUSG00000018209
  
Biological name :Stk4
  
Synonyms : Q9JI11 / serine/threonine kinase 4 / Stk4
  
Possible biological names infered from orthology : Q13043
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: H3
Gene start: 164070322
Gene end: 164155524
  
Corresponding Affymetrix probe sets: 10478447 (MoGene1.0st)   1421107_at (Mouse Genome 430 2.0 Array)   1434159_at (Mouse Genome 430 2.0 Array)   1436015_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000122440
Ensembl peptide - ENSMUSP00000018353
Ensembl peptide - ENSMUSP00000085629
Ensembl peptide - ENSMUSP00000116745
NCBI entrez gene - 58231     See in Manteia.
MGI - MGI:1929004
RefSeq - NM_021420
RefSeq - XM_006499963
RefSeq - XM_006499964
RefSeq Peptide - NP_067395
swissprot - Q8CDG4
swissprot - A2A5M9
swissprot - F7BYZ4
swissprot - Q9JI11
Ensembl - ENSMUSG00000018209
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 STK4ENSGALG00000004098Gallus gallus
 STK4ENSG00000101109Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Stk3 / Q9JI10 / Mus musculus serine/threonine kinase 3 (Stk3), transcript variant 2, mRNA. / Q13188* / serine/threonine kinase 3*ENSMUSG0000002232977
Stk24 / Q99KH8 / serine/threonine kinase 24 / Q9Y6E0*ENSMUSG0000006341036
Stk25 / Q9Z2W1 / Serine/threonine-protein kinase 25 / O00506* / serine/threonine kinase 25*ENSMUSG0000002627736
Stk26 / Q99JT2 / serine/threonine kinase 26 / Q9P289*ENSMUSG0000003111235


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011524  SARAH domain
 IPR017441  Protein kinase, ATP binding site
 IPR024205  Mst1 SARAH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IGI
 biological_processGO:0001841 neural tube formation IGI
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0003157 endocardium development IGI
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0007417 central nervous system development IGI
 biological_processGO:0008285 negative regulation of cell proliferation IGI
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0023014 signal transduction by protein phosphorylation IBA
 biological_processGO:0030216 keratinocyte differentiation IGI
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0035329 hippo signaling IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IGI
 biological_processGO:0046621 negative regulation of organ growth IGI
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0060215 primitive hemopoiesis IGI
 biological_processGO:0060706 cell differentiation involved in embryonic placenta development IGI
 biological_processGO:0060800 regulation of cell differentiation involved in embryonic placenta development IGI
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0097284 hepatocyte apoptotic process IGI
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IGI
 biological_processGO:1905461 positive regulation of vascular associated smooth muscle cell apoptotic process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0000291 enlarged pericardium "extended fibroserous membrane covering the heart and beginning of the great vessels" [J:29971]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0000350 abnormal cell proliferation "anomalous growth and reproduction of similar cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0000547 short limbs "reduced average length of the extremities" [MGI:CLS, J:61509]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * CBA * DBA

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * CBA * DBA

Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL

 MP:0000609 abnormal liver physiology "aberrant function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0000708 thymus hyperplasia "increased cell number in the thymus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]
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Allelic Composition: Foxq1sa/Foxq1sa,Lystbg/Lystbg
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10/Rl

 MP:0000714 increased thymocyte number "greater than expected number of precursors to T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pax6tm2Pgr/Pax6+,Tg(CAG-EGFP,-Pax6*5a,-lacZ)1Stoy/0,Tg(Dct-cre)1Apdn/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Stk4tm1.2Wtao/Stk4tm1.2Wtao
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0001701 incomplete embryo turning "arrest of the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [J:62571]
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0001712 abnormal placental development "malformed or incomplete differentiation of the organ of metabolic exchange between the fetus and mother" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0001713 reduced trophoblast cell number "fewer than normal number of cells of the extraembryonic cell layer that contributes to the placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:23171]
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0002038 carcinoma "malignant neoplasm arising from epithelial cells, usually glandular or squamous" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:58877]
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Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0002115 abnormal skeleton extremities morphology "abnormal development of limb, foot or tail bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Epha4m1Btlr/Epha4m1Btlr
Genetic Background: C57BL/6J-Epha4m1Btlr

Allelic Composition: Stk4m1Mhda/Stk4+
Genetic Background: C3HeB/FeJ-Stk4m1Mhda

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Foxq1sa/Foxq1sa,Lystbg/Lystbg
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10/Rl

 MP:0002391 abnormal Peyer s patch germinal center morphology "anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Foxq1sa/Foxq1sa,Lystbg/Lystbg
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10/Rl

 MP:0002392 abnormal Peyer s patch T cell area "anomalous structure or development of the Peyer s patch normally occupied by T lymphcytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxq1sa/Foxq1sa,Lystbg/Lystbg
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10/Rl

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxq1sa/Foxq1sa,Lystbg/Lystbg
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10/Rl

Allelic Composition: Stk4tm1.2Wtao/Stk4tm1.2Wtao
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxq1sa/Foxq1sa,Lystbg/Lystbg
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10/Rl

 MP:0002584 small ectoplacental cone 
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Foxq1sa/Foxq1sa,Lystbg/Lystbg
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10/Rl

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0002942 decreased circulating alanine transaminase level "decreased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Stk4tm1.1Kina/Stk4tm1.1Kina
Genetic Background: involves: C57BL/6

 MP:0003227 abnormal vascular branching morphogenesis "increase, decrease or anomaly in the process by which new vessels sprout off pre-existing vessels" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0003331 hepatocellular carcinoma "malignant neoplasm arising from liver cells" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Stk3tm1.1Jav/Stk3tm1.1Jav,Stk4Gt(AJ0315)Wtsi/Stk4+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Stk3tm1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Stk3tm1.1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Stk3tm1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL

Allelic Composition: Stk3tm1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003396 abnormal embryonic hematopoiesis "anomaly in the development of primarily large, nucleated erythroblasts as well as some megakaryocytes and primitive macrophages occuring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans " [J:94136, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Stk4tm1.1Kina/Stk4tm1.1Kina
Genetic Background: involves: C57BL/6

 MP:0003638 abnormal response/metabolism to endogenous compounds "altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0003883 enlarged stomach "increased size of the stomach" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * CBA * DBA

Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Stk3tm1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Stk3tm1.1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * CBA * DBA

Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0004265 abnormal placental transport "anomaly in the conveyance of metabolic products and nutrients across the placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0004392 abnormal CD8-positive T cell physiology "abnormal function of the subset of T lymphocytes that express the CD8 marker on the cell surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk4tm1.2Wtao/Stk4tm1.2Wtao
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0004686 decreased length of long bones "reduced end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxq1sa/Foxq1sa,Lystbg/Lystbg
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10/Rl

Allelic Composition: Stk4tm1.2Wtao/Stk4tm1.2Wtao
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxq1sa/Foxq1sa,Lystbg/Lystbg
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10/Rl

Allelic Composition: Stk4tm1.2Wtao/Stk4tm1.2Wtao
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Foxq1sa/Foxq1sa,Lystbg/Lystbg
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10/Rl

Allelic Composition: Stk4tm1.1Wtao/Stk4tm1.2Wtao,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL/J

Allelic Composition: Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0005141 liver hyperplasia "increased size of liver due to increased hepatocyte cell number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33827]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Stk3tm1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Stk3tm1.1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Stk3tm1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6

 MP:0005202 lethargy "mild impairment of consciousness resulting in reduced alertness and awareness; ultimately due to generalized brain dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0005348 increased T cell proliferation "increased clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

Allelic Composition: Stk4tm1.1Kina/Stk4tm1.1Kina
Genetic Background: involves: C57BL/6

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Stk4tm1.2Wtao/Stk4tm1.2Wtao
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0005632 decreased circulating aspartate transaminase level "less than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0005657 abnormal neural plate morphology "malformation or absence of the neuroectodermal area of the embryo s dorsal surface that develops into the neural tube and neural crest" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator, J:68142]
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0006055 abnormal vascular endothelial cell morphology "malformation in the cells that line the vasculature" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008019 liver tumor "presence of abnormal, rapidly proliferating cells in the liver usually in the form of a distinct mass" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy,Tg(CAG-cre/Esr1*)5Amc/0
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL

 MP:0008048 abnormal memory T cell number "deviation from the normal number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

Allelic Composition: Stk4tm1.1Wtao/Stk4tm1.2Wtao,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL/J

Allelic Composition: Stk4tm1.2Wtao/Stk4tm1.2Wtao
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

Allelic Composition: Stk4tm1.1Wtao/Stk4tm1.2Wtao,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL/J

Allelic Composition: Stk4tm1.2Wtao/Stk4tm1.2Wtao
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0008082 increased single-positive T cell number "greater number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk4tm1.1Kina/Stk4tm1.1Kina
Genetic Background: involves: C57BL/6

Allelic Composition: Stk4tm1.1Wtao/Stk4tm1.2Wtao,Tg(Lck-cre)#Zhu/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * SJL/J

Allelic Composition: Stk4tm1.2Wtao/Stk4tm1.2Wtao
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac

 MP:0008122 decreased myeloid dendritic cell number "reduction in the number of phagocytic cells of the myeloid lineage that capture antigens in the periphery and then migrate to the lymphoid organs and secrete cytokines to initiate immune responses" [PMID:10449155, PMID:9521319]
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Allelic Composition: Stk4tm1.1Kina/Stk4tm1.1Kina
Genetic Background: involves: C57BL/6

 MP:0008180 abnormal marginal zone B cell morphology "any structural anomaly of a CD23-negative, CD21-positive B cell of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk4tm1.1Kina/Stk4tm1.1Kina
Genetic Background: involves: C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Stk4tm1.1Kina/Stk4tm1.1Kina
Genetic Background: involves: C57BL/6

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Stk4tm1.1Kina/Stk4tm1.1Kina
Genetic Background: involves: C57BL/6

 MP:0008479 decreased spleen white pulp amount "reduction in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Hesx1tm3Jpmb/Hesx1tm3Jpmb
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0008891 decreased hepatocyte apoptosis "reduction in the number of hepatocytes undergoing programmed cell death" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0008944 decreased sensitivity to induced cell death "increase in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk3tm1.1Jav/Stk3tm1Jav,Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Genetic Background: involves: 129 * C57BL/6

 MP:0008989 abnormal liver sinusoid morphology "any structural anomaly of the hepatic distensible vascular blood channels lined with highly fenestrated endothelial cells that function to exchange fluids, nutrients, proteins and wastes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Stk3tm1.1Rjo/Stk3tm1.1Rjo,Stk4tm1.1Rjo/Stk4tm1.1Rjo,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CD-1 * DBA * SJL

 MP:0009321 histiocytic sarcoma 
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009658 increased placenta apoptosis "increase in the number of cells of the placenta undergoing programmed cell death" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Stk3tm1.1Yy/Stk3+,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0010819 primary atelectasis "nonexpansion of the lungs after birth, seen in stillborn organisms and in live born animals that do not establish respiration" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0011018 pulmonary hyaline membrane formation "abnormal presence of an eosinophilic hyaline (glass-like) material composed of fibrin, proteinaceous exudate and cellular debris, and lining or filling the alveoli, alveolar ducts and bronchioles; hyaline membranes block gas exchange and are usually found at autopsy in individuals that have died of respiratory distress syndrome in the neonatal stages" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Krastm4Tyj/Kras+,Tg(MUC1)79.24Gend/0
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0011139 increased lung endothelial cell proliferation "greater ability of an endothelial cell in the pulmonary vasculature to undergo expansion by cell division" [MGI:csmith]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Hsd11b1tm1Lex/Hsd11b1tm1Lex
Genetic Background: B6.129-Hsd11b1tm1Lex Apoetm1Unc

 MP:0013502 decreased fibroblast apoptosis "reduction in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Stk3tm1.1Yy/Stk3tm1.1Yy,Stk4tm1.1Yy/Stk4tm1.1Yy
Genetic Background: involves: C57BL/6 * CBA

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Stk3tm1Dlim/Stk3tm1Dlim,Stk4tm1Dlim/Stk4tm1Dlim
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021067 1 / Sav1 / Q8VEB2 / Q9H4B6* / salvador family WW domain containing protein 1*  / complex
 ENSMUSG00000006262 Mob1b / Q8BPB0 / MOB kinase activator 1B / Q7L9L4*  / reaction
 ENSMUSG00000040021 Lats1 / Q8BYR2 / Serine/threonine-protein kinase LATS1 / O95835* / large tumor suppressor kinase 1*  / reaction
 ENSMUSG00000018209 Stk4 / Q9JI11 / serine/threonine kinase 4 / Q13043*  / complex
 ENSMUSG00000043131 Mob1a / Q921Y0 / MOB kinase activator 1A / Q9H8S9*  / reaction
 ENSMUSG00000021959 Lats2 / Q7TSJ6 / Serine/threonine-protein kinase LATS2 / Q9NRM7* / large tumor suppressor kinase 2*  / reaction
 ENSMUSG00000031628 Casp3 / P70677 / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12 / P42574* / caspase 3*  / reaction






 

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