ENSGALG00000004098


Gallus gallus

Features
Gene ID: ENSGALG00000004098
  
Biological name :STK4
  
Synonyms : serine/threonine-protein kinase 4 / STK4
  
Possible biological names infered from orthology : Q13043 / Q9JI11 / serine/threonine kinase 4
  
Species: Gallus gallus
  
Chr. number: 20
Strand: -1
Band:
Gene start: 5330401
Gene end: 5370586
  
Corresponding Affymetrix probe sets: Gga.15820.1.S1_s_at (Chicken Array)   GgaAffx.12533.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000006511
Ensembl peptide - ENSGALP00000050899
Ensembl peptide - ENSGALP00000044959
NCBI entrez gene - 419187     See in Manteia.
RefSeq - NM_001030853
RefSeq - XM_015296362
RefSeq - XM_015296363
RefSeq Peptide - NP_001026024
swissprot - A0A1D5PDQ4
swissprot - A0A1D5NX66
swissprot - F1P4Y3
Ensembl - ENSGALG00000004098
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 STK4ENSG00000101109Homo sapiens
 Stk4ENSMUSG00000018209Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STK3 / serine/threonine-protein kinase 3 / Q9JI10* / Q13188* / serine/threonine kinase 3* / Mus musculus serine/threonine kinase 3 (Stk3), transcript variant 2, mRNA.*ENSGALG0000003285076
STK25 / serine/threonine-protein kinase 25 / O00506* / Q9Z2W1* / serine/threonine kinase 25*ENSGALG0000003773935
STK26 / serine/threonine kinase 26 / Q99JT2* / Q9P289*ENSGALG0000000604934
STK24 / serine/threonine kinase 24 / Q99KH8* / Q9Y6E0*ENSGALG0000001688526


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR011524  SARAH domain
 IPR017441  Protein kinase, ATP binding site
 IPR024205  Mst1 SARAH domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000902 cell morphogenesis IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0001841 neural tube formation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0003157 endocardium development IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007417 central nervous system development IEA
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0035329 hippo signaling IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0045600 positive regulation of fat cell differentiation IEA
 biological_processGO:0046621 negative regulation of organ growth IEA
 biological_processGO:0046777 protein autophosphorylation IEA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0060215 primitive hemopoiesis IEA
 biological_processGO:0060706 cell differentiation involved in embryonic placenta development IEA
 biological_processGO:0060800 regulation of cell differentiation involved in embryonic placenta development IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:0097284 hepatocyte apoptotic process IEA
 biological_processGO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000012386 LATS1 / large tumor suppressor kinase 1 / O95835* / Q8BYR2* / Serine/threonine-protein kinase LATS1 *  / reaction
 ENSGALG00000004098 STK4 / serine/threonine-protein kinase 4 / Q13043* / Q9JI11* / serine/threonine kinase 4*  / complex
 ENSGALG00000039203 MOB1A / MOB kinase activator 1A / Q921Y0* / Q9H8S9*  / reaction
 ENSGALG00000010638 CASP3 / caspase 3 / P42574* / P70677* / Caspase-3 Caspase-3 subunit p17 Caspase-3 subunit p12*  / reaction






 

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