ENSGALG00000012386


Gallus gallus

Features
Gene ID: ENSGALG00000012386
  
Biological name :LATS1
  
Synonyms : large tumor suppressor kinase 1 / LATS1
  
Possible biological names infered from orthology : O95835 / Q8BYR2 / Serine/threonine-protein kinase LATS1
  
Species: Gallus gallus
  
Chr. number: 3
Strand: -1
Band:
Gene start: 48334840
Gene end: 48350146
  
Corresponding Affymetrix probe sets: Gga.12564.1.S1_at (Chicken Array)   Gga.20043.1.S1_at (Chicken Array)   Gga.5533.1.S1_at (Chicken Array)   Gga.8389.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000020194
Ensembl peptide - ENSGALP00000056695
NCBI entrez gene - 421627     See in Manteia.
RefSeq - XM_419666
RefSeq - XM_004935608
RefSeq - XM_004935609
RefSeq - XM_004935606
RefSeq - XM_004935607
swissprot - E1C371
swissprot - A0A1D5PUT8
Ensembl - ENSGALG00000012386
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lats1ENSDARG00000003751Danio rerio
 LATS1ENSG00000131023Homo sapiens
 Lats1ENSMUSG00000040021Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
STK38L / serine/threonine kinase 38 like / Q7TSE6* / Q9Y2H1* / Mus musculus serine/threonine kinase 38 like (Stk38l), transcript variant 2, mRNA.*ENSGALG0000001409417
STK38 / serine/threonine kinase 38 / Q15208* / Q91VJ4* / Mus musculus serine/threonine kinase 38 (Stk38), transcript variant 2, mRNA.*ENSGALG0000000052317
CIT / citron rho-interacting serine/threonine kinase / O14578*ENSGALG0000000735414
ROCK1 / Rho associated coiled-coil containing protein kinase 1 / P70335* / Q13464* / Rho-associated protein kinase 1 *ENSGALG0000001492214
ROCK2 / Rho associated coiled-coil containing protein kinase 2 / O75116*ENSGALG0000001645114
CDC42BPA / CDC42 binding protein kinase alpha / Q3UU96* / Q5VT25* / Serine/threonine-protein kinase MRCK alpha *ENSGALG0000000915814
CDC42BPB / CDC42 binding protein kinase beta / Q7TT50* / Q9Y5S2*ENSGALG0000001143213


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR009060  UBA-like superfamily
 IPR011009  Protein kinase-like domain superfamily
 IPR015940  Ubiquitin-associated domain
 IPR028741  Serine/threonine-protein kinase LATS1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000082 G1/S transition of mitotic cell cycle IBA
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IEA
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0000819 sister chromatid segregation IEA
 biological_processGO:0001827 inner cell mass cell fate commitment IEA
 biological_processGO:0001828 inner cell mass cellular morphogenesis IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0009755 hormone-mediated signaling pathway IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0030216 keratinocyte differentiation IEA
 biological_processGO:0030833 regulation of actin filament polymerization IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0033146 regulation of intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0034613 cellular protein localization IEA
 biological_processGO:0035329 hippo signaling IBA
 biological_processGO:0043065 positive regulation of apoptotic process IBA
 biological_processGO:0043254 regulation of protein complex assembly IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IEA
 biological_processGO:0046620 regulation of organ growth IBA
 biological_processGO:0051220 cytoplasmic sequestering of protein IEA
 biological_processGO:0060644 mammary gland epithelial cell differentiation IEA
 biological_processGO:0090090 negative regulation of canonical Wnt signaling pathway IEA
 biological_processGO:2000058 regulation of ubiquitin-dependent protein catabolic process IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030331 estrogen receptor binding IEA


Pathways (from Reactome)
Pathway description
Signaling by Hippo


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000001826 WWC1 / WW and C2 domain containing 1 / Q5SXA9* / Q8IX03* / WW, C2 and coiled-coil domain containing 1*  / complex / reaction
 ENSGALG00000004098 STK4 / serine/threonine-protein kinase 4 / Q13043* / Q9JI11* / serine/threonine kinase 4*  / reaction
 ENSGALG00000010412 WWTR1 / WW domain containing transcription regulator 1 / Q9EPK5* / Q9GZV5*  / reaction
 ENSGALG00000039203 MOB1A / MOB kinase activator 1A / Q921Y0* / Q9H8S9*  / reaction / complex






 

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